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排序方式: 共有258条查询结果,搜索用时 15 毫秒
91.
KS Madhusudhan S Sharma DN Srivastava S Thulkar SN Mehta G Prasad V Seenu S Agarwal 《Journal of Medical Imaging and Radiation Oncology》2009,53(1):40-49
To prospectively compare the feasibility, safety and diagnostic role of carbon dioxide (CO2) digital subtraction angiography (DSA) using a ‘home made’ delivery system with iodinated contrast medium (ICM) DSA in the evaluation of peripheral arterial occlusive diseases (PAOD) of lower limbs. Twenty‐one patients (27 limbs; all men; mean age, 47.6 years) who presented with PAOD of lower limbs underwent DSA using both intra‐arterial CO2 and ICM. Conventional ICM DSA was performed first and used as gold standard. Carbon dioxide was then injected by hand using a locally improvised home made plastic bag delivery system. Patient tolerance was assessed subjectively. Arteries from aortic bifurcation to the ankle were independently evaluated by two radiologists and graded for stenosis using a five‐point scale. For each patient, the quality of CO2 DSA images were compared with the corresponding images of ICM DSA and an overall grade of ‘good’, ‘acceptable’ or ‘poor’ was assigned. Cohen’s kappa coefficient was used to determine inter‐observer agreement. Carbon dioxide opacified 86.2% (188/195) of major arteries and depicted stenosis adequately in 84.5% (191/226) of arterial segments. A good or acceptable image quality of CO2 DSA was obtained in over 95% of patients. Infrapopliteal arteries were inadequately visualized. Mild pain was seen in six (28.6%) patients with both contrast agents; one patient developed severe pain during CO2 DSA. Inter‐observer agreement was good (k > 0.75) at 70% of the segments. Administration of CO2 into lower limb arteries is well tolerated. Carbon dioxide DSA using the locally improvised home made delivery system is a feasible and safe alternative to ICM DSA in the evaluation of PAOD. It provides adequate imaging of arteries of lower extremities except infrapopliteal segments. 相似文献
92.
先天性无肛直肠舟状窝瘘手术186例 总被引:1,自引:0,他引:1
1临床资料1988-06/2003-12我院共186例,均为女性,无肛门,其中0~6月龄21例,0.5~1岁96例,1~3岁53例,3~8岁15例,13岁1例.以大便从会阴部舟状窝瘘口处排出而就诊,患儿有不同程度的排便困难,严重时伴腹胀呕吐,多数患儿有营养不良性贫血.瘘口直径0.3~0.6 cm,直肠盲端到肛穴皮肤之间的距离1.0~2.5 cm,属于中、低位肛门直肠畸形.本组有3例合并先天性心脏病-室间隔缺损,2例合并骶前囊肿,1例合并脐疝. 相似文献
93.
Antonia L Wadley Liesl M Hendry Peter R Kamerman Constance SN Chew Patricia Price Catherine L Cherry Zané Lombard 《European journal of human genetics : EJHG》2015,23(3):363-368
HIV-associated sensory neuropathy (HIV-SN) is a common neurological complication of HIV infection. The TNF block is a region within the central MHC that contains many immunoregulatory genes. Polymorphisms and haplotypes of the TNF block have been associated with increased risk of HIV-SN in Asians and whites. Here we investigated genetic associations with HIV-SN in 342 black Southern Africans (190 cases and 152 neuropathy-free controls) using single nucleotide polymorphisms (SNPs) spanning the TNF block and a set of haplotypes defined by 31 SNPs in Asian and white populations (denoted FVa). We included population-appropriate tagSNPs derived from an African population (Yoruban, YRI, HapMap) and derived extended haplotypes comprising 61 SNPs (denoted FVa_ext b). We found no association between HIV-SN and carriage of two SNPs (TNF-1031/rs1799964*C and BAT1 (intron10)/rs9281523*C) associated with HIV-SN in whites and Asians. Additionally, a haplotype containing TNF-1031/rs1799964*C associated with increased risk of HIV-SN in Asians, but was not present in this African population. However, alleles of seven SNPs associated with reduced risk of HIV-SN (corrected for age, height and multiple comparisons). These were rs11796*A, rs3130059*G, rs2071594*C, NFKBIL1-62/rs2071592*A, rs2071591*A, LTA+252/rs909253*G, rs1041981*C. One haplotype (FV18_ext1), not containing these alleles, was associated with increased risk of HIV-SN after correction for age, height and multiple comparisons. Our results confirm the involvement of genes in the TNF block in altering risk for HIV-SN, but genotypes critical in this African population differed from those affecting HIV-SN in whites and Asians. These differences support the need for genetic association studies in diverse populations. 相似文献
94.
95.
A diffuse granular mucosal pattern, produced by a reticular network of radiolucent foci 0.5 to 1 mm in diameter, was identified in 39 out of 46 consecutive patients with Crohn disease of the small intestine. Resected specimens demonstrated that this pattern represented wide, blunted villi with lymphocytic infiltration. Such a pattern was the only evidence of small bowel involvement in 17 cases. In 3 patients with the commonly recognized lesions, separate regions of diffuse granularity were seen. No such pattern was detected in normal patients. Demonstration of diffuse granularity may contribute to the diagnosis and management of Crohn disease. 相似文献
96.
97.
98.
Exosomes (EXO) derived from dendritic cells (DC) and tumor cells have been used to stimulate antitumor immune responses in animal models and in clinical trials. However, there has been no side-by-side comparison of the stimulatory efficiency of the antitumor immune responses induced by these two commonly used EXO vaccines. In this study, we selected to study the phenotype characteristics of EXO derived from a transfected EG7 tumor cells expressing ovalbumin (OVA) and OVA-pulsed DC by flow cytometry. We compared the stimulatory effect in induction of OVA-specific immune responses between these two types of EXO. We found that OVA protein-pulsed DCovA-derived EXO (EXODC) can more efficiently stimulate naive OVA-specific CD8+ T cell proliferation and differentiation into cytotoxic T lymphocytes in vivo, and induce more efficient antitumor immunity than EG7 tumor cell-derived EXO (EXOEG7). In addition, we elucidated the important role of the host DC in EXO vaccines that the stimulatory effect of EXO is delivered to T cell responses by the host DC. Therefore, DC-derived EXO may represent a more effective EXO-based vaccine in induction of antitumor immunity. 相似文献
99.
Assessment of a radioisotopic assay for vitamin B12 using an intrinsic factor preparation with R proteins blocked by vitamin B12 analogues 下载免费PDF全文
Barbara Bain GN Broom Jackie Woodside RA Litwinczuk SN Wickramasinghe 《Journal of clinical pathology》1982,35(10):1110-1113
A competitive protein binding radioassay kit for serum vitamin B12 has been assessed. Precision, linearity, sensitivity, and specificity have been found to be satisfactory. Falsely-normal assay results in patients with vitamin B12 deficiency have not been observed. 相似文献
100.
Human follicle fluid vascular endothelial growth factor concentrations are correlated with luteinization in spontaneously developing follicles 总被引:7,自引:2,他引:7
Anasti JN; Kalantaridou SN; Kimzey LM; George M; Nelson LM 《Human reproduction (Oxford, England)》1998,13(5):1144-1147
Vascular endothelial growth factor (VEGF) is a cytokine that induces
angiogenesis. Angiogenesis is a prominent histologic component of the
luteinization process. Luteinization is also characterized by granulosa
cell progesterone secretion in response to the luteinizing hormone (LH)
surge. Local VEGF production in human pre-ovulatory follicles, induced by
LH, was postulated to be a luteinization mediator in women. To investigate
this hypothesis, serum and fluid from the dominant follicle of 31 healthy
regularly cycling multiparous women undergoing laparoscopic sterilization
were obtained. VEGF was measured by enzyme- linked immunosorbent assay, and
LH and progesterone were measured by radioimmunoassay. Follicle aspiration
was performed at a median of 13 days from the last menstrual period (range
11-17 days). The median pre- ovulatory follicle diameter was 16 mm (range
11-23 mm). Follicle fluid VEGF concentrations (mean 6900 pg/ml, range
1200-17 100 pg/ml) were correlated positively with follicle fluid
progesterone concentrations (mean 10 176 nmol/l, range 636-66780 nmol/l,
r=0.62, P=0.002). This correlation was even tighter (r=0.87, P < 0.0001)
when only samples from the 22 women in the earliest stages of follicle
luteinization were considered. In these women serum LH concentrations were
also correlated with follicle fluid VEGF concentrations (r=0.51, P=0.02).
Our findings demonstrate the close dynamic relationship between VEGF
production and early luteinization in human follicles during normal
non-stimulated cycles.
相似文献