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排序方式: 共有848条查询结果,搜索用时 15 毫秒
841.
842.
Evaluation of Legionella V-TesT for the detection of Legionella pneumophila antigen in urine samples
Bruin J. P. Peeters M. F. IJzerman E. P. F. Diederen B. M. W. 《European journal of clinical microbiology & infectious diseases》2010,29(7):899-900
We evaluated a new immunochromatographic assay (Legionella V-TesT, Coris BioConcept, Gembloux, Belgium) for its ability to
detect Legionella pneumophila serogroup 1 antigen in urine. Test devices were read at various time points to determine the optimum incubation time regarding
performance. The results were compared with those obtained with the BinaxNOW urinary antigen test. The sensitivity and specificity
were 82.2% and 98.6%, respectively, for the Legionella V-TesT and 83.9% and 100%, respectively, for the BinaxNOW urinary antigen
test after 15 min of incubation. When tests were examined after 60 min, the sensitivity for both tests increased to 91.5%. 相似文献
843.
ESG Stroes JJP Kastelein A Bénardeau O Kuhlmann D Blum LA Campos RG Clerc EJ Niesor 《British journal of pharmacology》2009,158(7):1763-1770
Background and purpose:
The association between torcetrapib and its off-target effects on blood pressure suggested a possible class-specific effect. The effects of dalcetrapib (RO4607381/JTT-705) and torcetrapib on haemodynamics and the renin-angiotensin-aldosterone system (RAAS) were therefore assessed in a rat model.Experimental approach:
Arterial pressure (AP) and heart rate were measured by telemetry in normotensive and spontaneously hypertensive rats (SHR) receiving torcetrapib 10, 40 or 80 mg·kg−1·day−1; dalcetrapib 100, 300 or 500 mg−1·kg·day−1; or vehicle (placebo) for 5 days. Expression of RAAS genes in adrenal gland, kidney, aorta and lung from normotensive rats following 5 days'' treatment with torcetrapib 40 mg·kg−1·day−1, dalcetrapib 500 mg·kg−1·day−1 or vehicle was measured by quantitative polymerase chain reaction.Key results:
Torcetrapib transiently increased mean AP in normotensive rats (+3.7 ± 0.1 mmHg), whereas treatment in SHR resulted in a dose-dependent and sustained increase [+6.5 ± 0.6 mmHg with 40 mg·kg−1·day−1 at day 1 (P < 0.05 versus placebo)], which lasted over the treatment period. No changes in AP or heart rate were observed with dalcetrapib. Torcetrapib, but not dalcetrapib, increased RAAS-related mRNAs in adrenal glands and aortas.Conclusions and implications:
In contrast to torcetrapib, dalcetrapib did not increase blood pressure or RAAS-related gene expression in rats, suggesting that the off-target effects of torcetrapib are not a common feature of all compounds acting on cholesteryl ester transfer protein. 相似文献844.
Background
Cross-sectional study was carried out to determine the frequency of subtelomeric abnormalities in children with idiopathic mental retardation (MR).Method
Multiplex ligation-dependant probe amplification technique was used to detect subtelomeric abnormalities.Results
Out of 35 children, 21 (60%) were males. Family history of MR was present in 23%. Main clinical features included speech delay in all motor delay cases (83%) and non-specific dysmorphic features (77%).Conclusion
Associated clinical features were more in children with intelligence quotient (IQ) < 50 (P < 0.05). Subtelomeric deletion (4q35) was observed in one child. 相似文献845.
JKS PARIHAR RG DASH DP VATS SC VERMA PK SHOO FEA RODRIGUES AP KAMATH 《Medical Journal Armed Forces India》2001,57(3):207-209
30 cases of open angle glaucoma with cataract who underwent phacoemulsification, PMMA phaco profile IOL implantation and trabeculectomy through same incision were critically evaluated. The mean controlled, preoperative intra ocular pressure was 20 mm of Hg (range 18 to 35 mm of Hg) by aplanation method. Mean post operative pressure after 12 months was 13 mm of Hg (range 11 to 22 mm of Hg) intra operative hyphaema, post operative uveitis were noted problems. Periodic, post operative optic disc and field evaluation remained static in 66% cases. Visual acuity of 6/12 or better was achieved in 60% cases. Failure to restore glaucoma control without medication was seen in 13.3% cases after 9–12 months. The combined phacotrabeculectomy is an effective single step technique of managing concurrent glaucoma with cataract.Key words: Single incision, Phacotrabeculectomy 相似文献
846.
Effect of A3 pulley and adjacent sheath integrity on tendon excursion and bowstringing@Xie RG 相似文献
847.
848.