全文获取类型
收费全文 | 471篇 |
免费 | 22篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 71篇 |
口腔科学 | 25篇 |
临床医学 | 44篇 |
内科学 | 56篇 |
皮肤病学 | 26篇 |
神经病学 | 63篇 |
特种医学 | 27篇 |
外科学 | 62篇 |
综合类 | 2篇 |
预防医学 | 14篇 |
眼科学 | 7篇 |
药学 | 71篇 |
中国医学 | 5篇 |
肿瘤学 | 18篇 |
出版年
2023年 | 2篇 |
2022年 | 10篇 |
2021年 | 9篇 |
2020年 | 8篇 |
2019年 | 9篇 |
2018年 | 9篇 |
2017年 | 3篇 |
2016年 | 15篇 |
2015年 | 18篇 |
2014年 | 26篇 |
2013年 | 30篇 |
2012年 | 30篇 |
2011年 | 32篇 |
2010年 | 29篇 |
2009年 | 22篇 |
2008年 | 43篇 |
2007年 | 20篇 |
2006年 | 29篇 |
2005年 | 30篇 |
2004年 | 28篇 |
2003年 | 19篇 |
2002年 | 21篇 |
2001年 | 11篇 |
2000年 | 10篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1985年 | 1篇 |
1982年 | 1篇 |
1973年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有497条查询结果,搜索用时 125 毫秒
101.
Jong Han Kim Sang Young Han Ah Young Kang You Jeong Shon Young Hun Koo Seung Hoon Ryu Jeong Hwan Cho Seung Ho Han Sung Wook Lee Jin Seok Jang Jong Hoon Lee Myung Hwan Roh Seok Ryeol Choi 《Taehan Sohwagi Hakhoe chi》2005,46(4):283-290
BACKGROUND/AIMS: There are several staging systems to decide the stage of hepatocellular carcinoma (HCC), but yet incomplete. Okuda stage which includes both tumor characteristics and liver function is widely used. The aims of this study were to assess the usefulness of known prognostic factors and Okuda staging system in 237 cases of HCC. METHODS: A retrospective analysis of 237 cases of HCC diagnosed from 2000 to 2002 was performed. We analyzed prognostic factors such as age, sex, liver cirrhosis, Child-Pugh classification, tumor size, albumin, bilirubin, alpha-FP, ascites, encephalopathy and Okuda stage. Prognostic analysis was performed for single variables and estimating survival distributions were analyzed by the Kaplan-Meier method, statistically compared by the log-rank test. RESULTS: Patients had a mean age of 57.5 years and were predominantly men (79.7%). Liver cirrhosis were noticed in 214 cases (90.3%). The overall median survival period was 25.7 months. The median survival period was correlated to bilirubin, ascites, alpha-FP, tumor size, and Child-Pugh classification, but not to age, sex, and pattern of viral infection. The median survival period of the Okuda stage I, II and III cases was 35.8, 11.9 and 8.5 months (p<0.001). CONCLUSIONS: The median survival period of patients with HCC is significantly correlated to Okuda staging system, and survival period has improved than the initial data when the Okuda staging system was published in 1985. However, in order to discriminate early staged HCC more accurately, other prognostic factors such as alpha-FP and tumor morphology should be included in future staging system for HCC. 相似文献
102.
Hyun-Chul Lee Jong Gwang Kim Yee Soo Chae Sang Kyun Sohn Byung Woog Kang Joon Ho Moon Seong Woo Jeon Myung-Hoon Lee Kyoung-Hoon Lim Jin Young Park Gyu Seog Choi Soo-Han Jun 《Journal of cancer research and clinical oncology》2010,136(7):1073-1078
Purpose
The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with colorectal cancer.Methods
Four hundred and twenty-six consecutive patients with surgically treated colorectal adenocarcinoma were enrolled. The genomic DNA was extracted from fresh colorectal tissue and 40 polymorphisms of miRNA-related genes determined using a real-time PCR genotyping assay.Results
In a univariate analysis, the progression-free survival of the patients with the combined mir492 C/G and G/G genotype was significantly worse than that of the patients with the mir492 C/C genotype (rs2289030) (P value = 0.0426), although there was no difference in the overall survival. However, no association was noted between the SNPs of the miRNA-related genes evaluated and survival in a multivariate analysis.Conclusions
None of the 40 miRNA-related gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer. However, further studies are warranted to clarify the role of miRNA-related gene polymorphisms as a prognostic biomarker for colorectal cancer patients. 相似文献103.
Trend analysis of diabetic prevalence and incidence in a rural area of South Korea between 2003–2008
Ji Yun Jeong Jung‐Guk Kim Bo‐Wan Kim Seong Su Moon Hye‐Soon Kim Keun‐Gyu Park Kyu Chang Won Hyoung Woo Lee Ji Sung Yoon Ho‐Sang Shon Ji Hyun Lee Eui‐Dal Jung Mi Young Park Byung‐Yeol Chun Keon‐Yeop Kim Tae‐Yoon Hwang Mi‐Young Lee In‐Kyu Lee 《Journal of diabetes investigation.》2010,1(5):184-190
Aims/Introduction: This study determined the change in prevalence of diabetes and prediabetes over a period of 5 years in South Korea. The incidence of diabetes and prediabetes and risk factors associated with the development of diabetes were also investigated. Materials and Methods: The Dalseong population‐based cohort survey recruited 1806 subjects who were over 20‐years‐old in 2003. Five years later, 1287 of the original subjects were re‐evaluated and 187 new subjects were added to the study. All participants completed a questionnaire, were given a physical examination, and provided blood samples for analysis including 2 h oral glucose tolerances. Results: Age‐adjusted prevalence of diabetes rose from 6.7% in 2003 to 9.1% in 2008. The prevalence of prediabetes also increased from 18.5% in 2003 to 28.4% in 2008. The incidence rates of diabetes and prediabetes were 18.3 per 1000 person‐years and 55.4 per 1000 person‐years, respectively. The development of diabetes was associated with impaired fasting glucose (IFG) (odds ratio [OR] 5.661), impaired glucose tolerance (IGT) (OR: 6.013), age (OR 1.013), and waist‐to‐hip ratio (OR 1.513). After excluding the IFG and IGT, systolic blood pressure (OR 1.023), high‐sensitivity C‐reactive protein (hsCRP; OR 1.097), triglyceride (OR 1.002) and waist‐to‐hip ratio (OR 1.696) were statistically significant risk factors in a multivariate logistic regression analysis. Conclusions: A significant rise in the prevalence of diabetes and prediabetes was observed between 2003 and 2008. In addition, this study newly demonstrated that waist‐to‐hip ratio and hsCRP were associated with the development of diabetes after adjusting for several confounding factors. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00045.x, 2010) 相似文献
104.
105.
Byung-Ki Cho Yong-Min Kim Dong-Soo Kim Eui-Sung Choi Hyun-Chul Shon Kyoung-Jin Park Eun-Myung Lee 《Clinics in Orthopedic Surgery》2009,1(3):123-127
Background
This study examined the clinical results of surgical treatment using a mini-open muscle resection procedure under local anesthesia for intractable lateral or medial epicondylitis.Methods
Forty two elbows (41 patients) were treated surgically for lateral or medial epicondylitis. The indication for surgery was refractory pain after six months of conservative treatment, or a history of more than three local injections of steroid, or severe functional impairment in the occupational activities. The treatment results were assessed in terms of the pain using the visual analogue scale (VAS), Roles & Maudsley score, and Nirschl & Pettrone grade.Results
The preoperative VAS scores of pain were an average of 5.36 at rest, 6.44 at daily activities, and 8.2 at sports or occupational activities. After surgery, the VAS scores improved significantly (p < 0.01): 0.3 at rest, 1.46 at daily activities, and 2.21 at sports or occupational activities. The preoperative Roles & Maudsley score was acceptable in 6 cases, and poor in 36 cases, which was changed to excellent in 23 cases, good in 16 cases, acceptable in 3 cases after surgery. According to the grading system by Nirschl & Pettrone, 23 cases were excellent, 18 cases were good, and the remaining 1 case was fair. Overall, 41 cases (97.6%) achieved satisfactory results. Postoperative complications were encountered in three cases. Subcutaneous seroma due to the leakage of joint fluid in two patients was managed by additional surgery and suction drainage, and resulted in a satisfactory outcome. One patient complained of continuous pain on occupational activity, but her pain at rest was improved greatly.Conclusions
The mini-open muscle resection procedure under local anesthesia appears to be one of effective methods for intractable lateral or medial epicondylitis. 相似文献106.
Mismatch between PFNa and medullary canal causing difficulty in nailing of the pertrochanteric fractures 总被引:3,自引:0,他引:3
Hwang JH Oh JK Han SH Shon WY Oh CW 《Archives of orthopaedic and trauma surgery》2008,128(12):1443-1446
The proximal femoral nail (PFN) and the proximal femoral nail anti-rotation (PFNA) have been successfully used in the management
of osteoporotic pertrochanteric fractures. Although many studies have described the geometrical mismatch between the antecurvation
of the femur and the contemporary intramedullay nails, technical difficulties related to the mismatch between the femoral
bowing and the PFN/PFNA at the time of nailing have rarely been discussed in the literature. We have experienced a technical
difficulty related to the mismatch between the medullary canal and the PFN/PFNA. We describe the complications related with
the mismatch and the technical pitfalls and some technical tips to avoid this problem are also described.
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea. (Project
ID:A060465). 相似文献
107.
Seong Yong Park Hyun-Chul Joo Young-Nam Youn Young-Hwan Park Han Ki Park 《Circulation journal》2008,72(3):492-495
Berry syndrome is a very rare congenital cardiovascular anomaly that consists of a distal aortopulmonary window, aortic origin of the right pulmonary artery, an intact ventricular septum, a patent ductus arteriosus, and an interrupted aortic arch. Two cases of Berry syndrome are presented. A one-stage surgical correction for this complex anomaly was successfully performed, and a 1-year follow-up demonstrated favorable outcomes. 相似文献
108.
Ginkgolide C inhibits platelet aggregation in cAMP- and cGMP-dependent manner by activating MMP-9 总被引:1,自引:0,他引:1
In this report, we investigated the effect of ginkgolide C (GC) from Ginkgo biloba leaves in collagen (10 mug/ml)-stimulated platelet aggregation. It has been known that matrix metalloproteinase-9 (MMP-9) is released from human platelets, and that it significantly inhibited platelet aggregation stimulated by collagen. Zymographic analysis confirmed that pro-MMP-9 (92-kDa) was activated by GC to form an activated MMP-9 (86-kDa) on gelatinolytic activities. And then, GC dose-dependently inhibited platelet aggregation, intracellular Ca(2+) mobilization, and thromboxane A(2) (TXA(2)) formation in collagen-stimulated platelets. In addition, GC significantly increased the formation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which have an anti-platelet function in both resting and collagen-stimulated platelets. Therefore, we demonstrate that the inhibitory effect of GC on platelet aggregation might be involved into the following pathways. GC may increase intracellular cAMP and cGMP production and MMP-9 activity, inhibit intracellular Ca(2+) mobilization and TXA(2) production, thereby leading to inhibition of platelet aggregation. These results strongly indicate that GC is a potent inhibitor of collagen-stimulated platelet aggregation. It may be a suitable tool for a negative regulator during platelet activation. 相似文献
109.
BACKGROUND: Although neoadjuvant chemotherapy is increasingly used for breast cancer, if a patient has a complete clinical response, it is often difficult for the surgeon to know exactly where and how much breast tissue to remove. METHODS: A method is described where the edges of the tumor are tattooed prior to chemotherapy, allowing all tissue initially involved with tumor to be resected following the chemotherapy. RESULTS: Thirty-four cases have been tattooed prior to neoadjuvant chemotherapy, and the clinical and pathological complete response rates were 56% and 22%, respectively. The tattoos allowed very accurate localization of the residual tumor location and extent. Of the 22 patients who have so far undergone lumpectomy, 77% had residual pathologic evidence of tumor, but the margins were negative in 91% at the first operation. Only 2 patients had to undergo a mastectomy because of persistently positive margins. CONCLUSIONS: The technique of breast tattooing is a simple and practical method to guide the extent of breast surgery following neoadjuvant chemotherapy. In contrast to placement of clips, the technique does not require needle localization, and it allows accurate determination of the initial tumor size and margins. 相似文献
110.
AIMS: The objective of this study was to characterize the inhibitory effects of Weissella cibaria isolates on volatile sulphur compounds (VSC) production both in vitro and in vivo. MATERIAL AND METHODS: We isolated and identified three hydrogen peroxide-generating lactobacilli from children's saliva, and assessed their inhibitory effects on VSC production and Fusobacterium nucleatum proliferation. Clinical studies were conducted with 46 subjects in order to measure the VSC of their mouth air. RESULTS: These lactobacilli were identified as W. cibaria. These isolates inhibited the production of VSC by F. nucleatum (p<0.05). The concentration of F. nucleatum was decreased by 5-log cycles as a result of exposure to the W. cibaria strains (p<0.05), whereas the catalase-treated W. cibaria cultures exerted no evident inhibitory effects on F. nucleatum replication. In the clinical studies, gargling with one isolate resulted in a significant reduction in the levels of H2S and CH3SH by approximately 48.2% (p<0.01) and 59.4% (p<0.05), respectively. CONCLUSIONS: These results indicate that W. cibaria isolates possess the ability to inhibit VSC production under both in vitro and in vivo conditions, demonstrating that they bear the potential for development into novel probiotics for use in the oral cavity. 相似文献