介入栓塞治疗用电解脱弹簧圈的电化学研究

本文研究了用 于介入栓塞颅内 动脉瘤的不锈 钢弹簧圈在 生理盐 水中阳 极溶解 电化 学过程, 确定 了溶断弹簧圈的 电流范围。分析 了不同材料及 表面预处理 对不锈 钢孔蚀 电位的 影响, 为电解 脱离 弹簧圈的选择提 供了依据     

血管迷走性晕厥的直立倾斜试验及药物疗效观察

对７４例不明原因晕厥患者进行直立倾斜试验。方法：采用自制手动式直立倾斜试验台,对阳性 病例选用氨酰心安或倍它乐克治疗,原有或经β－受体阻滞剂后发生心动过缓者同服６５４－２或改用氨茶碱,用药６ ｄ 后重复试验。结果：诱发出晕厥者４２例（５６．７６％）,其中心脏抑制型４例（９．５２％）,血管抑制型６例（１４．２８％）,混合 型３２例（７６．１９％）,阳性组发作时最低血压为零,最低心率４０次／ｍｉｎ,心电图主要改变为交界性逸搏心律,发作时 症状为晕厥、心悸、恶心、发汗,经平卧位后,上述改变均可恢复,无任何并发症。经氨酰心安治疗的１１例中９例转 阴,倍它乐克１４例中１１例阴转,氨茶碱３例中无１例阴转。结论：①直立倾斜试验既是诊断血管迷走性晕厥的简 便有效的措施,也是判断药物疗效的可靠方法。②β－受体阻滞剂氨酰心安、倍它乐克是治疗血管迷走性晕厥的有效 药物。     

孕期沙眼衣原体、支原体感染治疗效果与胎儿状况相关性研究

研究孕期沙眼衣原体,支原体感染治疗效果与胎儿生长发育的关系。方法应用免疫荧光法对６００例孕妇宫颈分泌物行沙眼衣原体,支原体属抗原检测,阳性者对配偶行尿道分泌物检测,孕妇阳性者以口服红霉素治疗,观察治疗过程中,胎儿异常及低休 儿发生比较及与配遇感染的关系。     

颞肌筋膜瓣在上颌骨缺损修复中的应用

目的与方法：本文总结了颞肌筋膜瓣修复上颌骨缺损２０例经验。其中上颌骨全部切除９例,上颌骨扩大切除３例,上颌骨部分切除８例。结果与结论：颞肌筋膜瓣全部成活,口腔内无覆盖的颞肌筋膜瓣发生上皮化。２例术后出现轻度张口受限外,未发现其它并发症,作者对颞肌筋膜剖要点及手术方法进行了描术,并对颞肌膜瓣的优点及注意事项进行了讨论。     

Computerized analysis of lesions in US images of the breast

RATIONALE AND OBJECTIVES: Breast sonography is not routinely used to distinguish benign from malignant solid masses because of considerable overlap in their sonographic appearances. The purpose of this study was to investigate the computerized analyses of breast lesions in ultrasonographic (US) images in order to ultimately aid in the task of discriminating between malignant and benign lesions. MATERIALS AND METHODS: Features related to lesion margin, shape, homogeneity (texture), and posterior acoustic attenuation pattern in US images of the breast were extracted and calculated. The study database contained 184 digitized US images from 58 patients with 78 lesions. Benign lesions were confirmed at biopsy or cyst aspiration or with image interpretation alone; malignant lesions were confirmed at biopsy. Performance of the various individual features and output from linear discriminant analysis in distinguishing benign from malignant lesions was studied by using receiver operating characteristic (ROC) analysis. RESULTS: At ROC analysis, the feature characterizing the margin yielded Az values (area under the ROC curve) of 0.85 and 0.75 in distinguishing between benign and malignant lesions for the entire database and for an "equivocal" database, respectively. The equivocal database contained lesions that had been proved to be benign or malignant at cyst aspiration or biopsy. Linear discriminant analysis round-robin runs yielded Az values of 0.94 and 0.87 in distinguishing benign from malignant lesions for the entire database and for the equivocal database, respectively. CONCLUSION: Computerized analysis of US images has the potential to increase the specificity of breast sonography.     

慢性肾功能不全患者血清HA、LN和β2-MG检测意义及评价

目的研究慢性肾功能不全患者血清透明质酸(HA)、层粘蛋白(LN)、β2-微球蛋白(β2-MG)水平变化及意义。方法采用放射免疫法测定76例慢性肾功能不全患者及20例健康献血员血清HA、LN水平,根据血肌酐(cr)水平分氮质血症组(A组)、尿毒症组(B组)、正常对照组(C组)比较上述各项指标。结果慢性肾功能不全患者(A组、B组)上述各项指标均高于正常健康组(C组)(P<0.01或P<0.05)。结论血清HA、LN及血β2-MG联合检测可以作为反映并鉴别肾功能损坏程度及预告指标之一。     

新生儿呼吸窘迫综合征肺表面活性物质治疗后肺氧合功能和尿量变化的观察

目的　探讨新生儿呼吸窘迫综合征 (RDS)予肺表面活性物质 (PS)治疗后的尿量变化及尿量与肺氧合功能的关系。方法　对新生儿重症监护病房 (NICU)行呼吸机治疗的 2 0例RDS患儿予血气监测及每小时尿量和入量监测。结果　观察组 (PS组 )最大尿量峰值出现于生后 6 0h ,与对照组比较有显著性差异 (P <0 0 5 )。尿量 /入量比值PS组于生后 48h即大于 0 8,而对照组的上述比值大于 0 8出现于生后 6 0h。尿量与动脉 /肺泡氧分压比值 (PaO2 /PAO2 )有显著相关性 (r =0 7414,P <0 0 5 )。结论　RDS病程中随着尿量增加肺氧合功能改善 ,予PS治疗后利尿期最大尿量峰值增大 ,出现时间早 ,提示在PS治疗后更应该密切观察尿量变化 ,判断病情的恢复。     

Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck.

PURPOSE: The epidermal growth factor receptor (EGFR) is a mediator of squamous cell carcinoma of the head and neck (SCCHN) development. ZD1839 is an orally active, selective EGFR tyrosine kinase inhibitor. This phase II study sought to explore the activity, toxicity, and pharmacodynamics of ZD1839 in SCCHN. PATIENTS AND METHODS: Patients with recurrent or metastatic SCCHN were enrolled through the University of Chicago Phase II Consortium. Patients were allowed no more than one prior therapy for recurrent or metastatic disease and were treated with single-agent ZD1839 500 mg/d. Patient tumor biopsies were obtained and stained immunohistochemically for EGFR, extracellular signal-regulated kinase 1 (ERK1), and phosphorylated ERK1 (p-ERK). Study end points included response rate, time to progression, median survival, and inhibition of p-ERK. RESULTS: Fifty-two patients were enrolled (40 male and 12 female) with a median age of 59 years (range, 34 to 84 years). Fourteen patients received ZD1839 through a feeding tube. Half the cohort received ZD1839 as second-line therapy. Forty-seven patients were assessable for response, with an observed response rate of 10.6% and a disease control rate of 53%. Median time to progression and survival were 3.4 and 8.1 months, respectively. The only grade 3 toxicity encountered was diarrhea in three patients. Performance status and development of skin toxicity were found to be strong predictors of response, progression, and survival. Ten biopsy samples were assessable and revealed no significant change in EGFR or p-ERK expression with ZD1839 therapy. CONCLUSION: ZD1839 has single-agent activity and is well tolerated in refractory SCCHN. In contrast to other reports, development of skin toxicity was a statistically significant predictor of response and improved outcome.     

休克期削痂加复合植皮治疗大面积深度烧伤

目的　探讨休克期削痂加复合植皮治疗大面积深度烧伤的可行性。方法　对 15例烧伤面积(70 5± 19 2 ) %、深Ⅱ～Ⅲ度面积平均 (5 0 1± 2 0 5 ) %的患者采用休克期削痂加复合植皮 ,第一次手术时间是伤后 2 4～ 4 8h ,一次削痂面积约 (30 6± 9 3) % ,以神态、尿量、心率和中心静脉压 (centrevainpressure,CVP)为主要监护指标。结果　术中术后各监护指标在正常范围。治疗组病例全部治愈出院 ,与条件相似 16例休克期后削痂植皮患者对比 ,创面愈合天数缩短 12d左右。结论　休克期削痂加复合植皮治疗大面积深度烧伤是可行的。     

Ⅱ型糖尿病和高血压患者血液动力学改变的相关因素分析

目的：探讨糖病和高血压血管并发症的发生机理。方法：分别测定高血压（ＨＴ）组、Ⅱ型糖尿病（ＮＩＤ－ＤＭ）组及Ⅱ型糖尿病合并高血压组和对照组的胰岛素水平、血脂、心脏彩超和血液流变学指标。结果：３个试验组的周围总阻（ＴＰＲ）、甘油三酯（ＴＧ）和胰岛素面积（ＩｎｓＳ）均明显增高,其中ＨＴ组和ＮＩＤＤＭ合并ＨＴ组的左室收缩期峰值室壁应力（ＰＳＳ）也明显增高：ＮＩＤＤＭ合并ＨＴ组ＩｎｓＳ明显高于其他三组,三试