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101.
Fuenmayor C Higuchi ML Carrasco H Parada H Gutierrez P Aiello V Palomino S 《Acta cardiologica》2005,60(1):33-37
OBJECTIVE: The present work analysed endomyocardial biopsies of patients with acute Chagas' disease in order to evaluate the frequency and intensity of T. cruzi antigens, CD4+ and CD8+ T cells to determine the characteristics of this recurrent disease in Venezuela. MATERIAL AND METHODS: Twelve endomyocardial biopsies of patients with Chagas' disease, 12 to 51 years old, (7M and 5F) were analysed. T. cruzi antigens and CD4+ (helper) and CD8+ (cytotoxic-suppressor) T cells were detected by the immunoperoxidase technique.The presence and intensity of lymphocytic myocarditis was evaluated according to the degree of myocardial fibre injury caused by inflammatory infiltrate. RESULTS: Myocarditis was present in 100% of the cases. The mean numbers of CD4+ T cell and CD8+ T cell were 11.00 (+/- 10.29); 14.69 (+/- 13.08) and the CD4/CD8 T cell ratio was 0.75. T. cruzi antigens were detected in 58%. There was a good correlation between the numbers of CD4 and CD8 T cells of each case and a lack of correlation with the amount of T. cruzi antigens. CONCLUSION: All patients with acute Chagas' disease show some degree of myocarditis that seems to be directly related to the presence of parasitic antigens. Both CD4 and CD8 T cells participate in this process.We are following these patients to see if patients with severe myocarditis and more parasite antigens in the acute phase will develop chronic heart failure. 相似文献
102.
Sarah N. Garfinkel Adam B. Barrett Ludovico Minati Raymond J. Dolan Anil K. Seth Hugo D. Critchley 《Psychophysiology》2013,50(6):505-512
Mental functions are influenced by states of physiological arousal. Afferent neural activity from arterial baroreceptors at systole conveys the strength and timing of individual heartbeats to the brain. We presented words under limited attentional resources time‐locked to different phases of the cardiac cycle, to test a hypothesis that natural baroreceptor stimulation influences detection and subsequent memory of words. We show memory for words presented around systole was decreased relative to words at diastole. The deleterious memory effect of systole was greater for words detected with low confidence and amplified in individuals with low interoceptive sensitivity, as indexed using a heartbeat counting task. Our observations highlight an important cardiovascular channel through which autonomic arousal impacts a cognitive function, an effect mitigated by metacognition (perceptual confidence) and interoceptive sensitivity. 相似文献
103.
Arbelo Nestor López-Pelayo Hugo Sagué María Madero Santiago Pinzón-Espinosa Justo Gomes-da-Costa Susana Ilzarbe Lidia Anmella Gerard Llach Cristian-Daniel Imaz María-Luisa Cámara María-Mercé Pintor Luis 《The Psychiatric quarterly》2021,92(3):1021-1033
Psychiatric Quarterly - The Coronavirus Disease 2019 (COVID-19) can affect mental health in different ways. There is little research about psychiatric complications in hospitalized patients with... 相似文献
104.
Minkwan Kim Seung-Pyo Lee Soongu Kwak Seokhun Yang Yong-Jin Kim Daniele Andreini Mouaz H. Al-Mallah Matthew J. Budoff Filippo Cademartiri Kavitha Chinnaiyan Jung Hyun Choi Edoardo Conte Hugo Marques Pedro de Araújo Gonçalves Ilan Gottlieb Martin Hadamitzky Jonathon A. Leipsic Erica Maffei Hyuk-Jae Chang 《Journal of Cardiovascular Computed Tomography》2021,15(3):232-239
BackgroundThe association of age with coronary plaque dynamics is not well characterized by coronary computed tomography angiography (CCTA).MethodsFrom a multinational registry of patients who underwent serial CCTA, 1153 subjects (61 ± 5 years old, 61.1% male) were analyzed. Annualized volume changes of total, fibrous, fibrofatty, necrotic core, and dense calcification plaque components of the whole heart were compared by age quartile groups. Clinical events, a composite of all-cause death, acute coronary syndrome, and any revascularization after 30 days of the initial CCTA, were also analyzed. Random forest analysis was used to define the relative importance of age on plaque progression.ResultsWith a 3.3-years’ median interval between the two CCTA, the median annual volume changes of total plaque in each age quartile group was 7.8, 10.5, 10.8, and 12.1 mm3/year and for dense calcification, 2.5, 4.6, 5.4, and 7.1 mm3/year, both of which demonstrated a tendency to increase by age (p-for-trend = 0.001 and < 0.001, respectively). However, this tendency was not observed in any other plaque components. The annual volume changes of total plaque and dense calcification were also significantly different in the propensity score-matched lowest age quartile group versus the other age groups as was the composite clinical event (log-rank p = 0.003). In random forest analysis, age had comparable importance in the total plaque volume progression as other traditional factors.ConclusionsThe rate of whole-heart plaque progression and dense calcification increases depending on age. Age is a significant factor in plaque growth, the importance of which is comparable to other traditional risk factors.Clinical trial registrationURL: http://www.clinicaltrials.gov. Unique identifiers: NCT02803411. 相似文献
105.
Juan David Farfán-Albarracín Cristina Lorena Ramírez-Sierra Oscar Mauricio Espitia Segura Sofy Helena Pérez Hugo Andrés Téllez Prada María Camila Rueda Rodríguez Ingrid Lemus Espitia Ana Maritza Bedoya 《Brain & development》2021,43(1):63-68
IntroductionThe ratio of cerebrospinal fluid (CSF) glucose and blood glucose is of major relevance, conducting to the diagnosis of hypoglycorrhachia, which is a sign of neuroinfection, as well as a number of neurological diseases of genetic or neoplastic etiology. Glucose in capillary sample (glucometry) is a low cost, readily available technique, as compared to venous glucose. This study aims to compare glucometry to venous glucose in the diagnosis of hypoglycorrhachia in pediatric population.MethodsProspective cross-sectional study based on data obtained from lumbar punctures in the period from February 2017 to January 2019 in a specialized pediatric institution in Colombia.Results97 patients were analyzed, aged 1 month to 17 years old, mean 7.67 years, 52 (53.61%) were female. 26 (26.8%) were diagnosed with hypoglycorrhachia. Pearson correlation coefficient for absolute venous and capillary glucose was 0.54, and 0.55 for the ratios of CSF glucose/venous glucose and CSF glucose/glucometry, which support a linear correlation between the variables in both, absolute values and ratios. Intraclass correlation coefficient was calculated for both, the venous glucose and glucometry ratios, which was 0.52, revealing a moderate agreement among the tests. Sensitivity and specificity of CSF glucose/glucometry, as compared to gold standard are 73.1% and 60.6% respectively; whereas predictive positive value (PPV) and negative predictive value (NPV), were 40.4% and 86.0%.ConclusionGlucometry cannot replace the glucose in venous sample in the diagnosis of hypoglycorrhachia in children. 相似文献
106.
Noor H. A. Suaini Evelyn Xiu-Ling Loo Rachel L. Peters Gaik Chin Yap Katrina J. Allen Hugo Van Bever David J. Martino Anne Eng Neo Goh Shyamali C. Dharmage Marjorelee T. Colega Mary Foong Fong Chong Anne-Louise Ponsonby Kok Hian Tan Mimi L. K. Tang Keith M. Godfrey Bee Wah Lee Lynette Pei-Chi Shek Jennifer J. Koplin Elizabeth Huiwen Tham 《Allergy》2021,76(10):3171-3182
107.
Deivi Cascante-Sequeira Hugo Gaêta-Araujo Leonardo Vieira Peroni Christiano Oliveira-Santos Francisco Haiter-Neto 《Dento maxillo facial radiology》2021,50(4)
Objective:To create and validate two new Image Receptor-Holding devices (IRHDs) to reduce proximal surfaces overlapping in bitewing radiography in comparison to a regular well-established and commercially available IRHD.Methods:Two IRHDs for bitewing radiographs with a wedge on the biting surface were designed and 3D-printed. These IRHDs, with a large wedge (Pr-Lw) and small wedge (Pr-Sw), were compared with a regular commercially available IRHD (Rinn XCP®) during image acquisition of bitewing radiographs of four posterior regions (one upper region and three lower regions) in two dry skulls and mandibles. A total of 156 interproximal regions on bitewing radiographs were radiographed by 13 oral radiology graduate students and independently assessed by two oral radiologists (10 years of experience). IRHDs were compared by Cochran’s Q test regarding the number of overlapped proximal surfaces in the acquired radiographs with a significance level of 5%.Results:The observers were in perfect agreement (κ = 1.0) to classify the proximal surfaces overlapping. The Pr-Lw IRHD presented the lowest number of surfaces overlapping (19.2%) followed by the Pr-Sw IRHD (48.1%) and the XCP®IRHD with the highest surfaces overlapping (71.2%). The Pr-Lw IRHD surfaces overlapping was statistically different from the XCP IRHD (p < 0.001), and the Pr-Sw IRHD (p = 0.014).Conclusions:The Pr-Lw IRHD demonstrated the most efficient performance in overlapping surfaces reduction, compared with the Pr-Sw IRHD and the XCP® IRHD in adult dry skulls and mandibles. 相似文献
108.
109.
Luiza Lassi de Araújo Lopes Paulo Goberlânio de Barros Silva Juliana Ximenes Damasceno Joyce Ohana de Lima Martins Karla Rovaris da Silva Frederico Barbosa de Sousa Hugo Victor Dantas Thyciana Rodrigues Ribeiro Phillipe Nogueira Barbosa Alencar 《Orthodontics & craniofacial research》2021,24(1):96-101
110.
Cunha Hugo Santos da Costa Moraes Cícero André de Faria Valle Dornelles Rodrigo da Rosa Everton Luis Santos 《Oral and maxillofacial surgery》2021,25(3):319-335
Oral and Maxillofacial Surgery - To assess whether virtual simulations of the projection of the soft tissues of the face after class II bimaxillary orthognathic surgery, generated from 3D... 相似文献