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101.
Rahimzadeh-Rofouyi B Afsharimani B Moezi L Ebrahimi F Mehr SE Mombeini T Ghahremani MH Dehpour AR 《Journal of cardiovascular pharmacology》2007,50(6):641-646
The mechanism of lithium action, an effective treatment for bipolar disease, is still unknown. The present study examined the role of nitric oxide (NO) and prostaglandin systems in lithium modulation of acetylcholine in mesenteric vascular bed of rats by cannulating superior mesenteric artery. Acetylcholine (ACh) or sodium nitroprusside was injected under constant controlled flow induced by phenylephrine; therefore, changes in perfusion pressure reflect changes in resistance. Although 0.5 mM or 1 mM lithium-pretreatment of vascular bed causes reduction in ACh-response, 1.5 mM lithium induced no changes and 2 and 2.5 mM lithium potentiated ACh-induced mesenteric vascular bed relaxation compared to control group. Pretreatment of vascular bed with L-NAME or indomethacin decreased ACh-induced relaxation in 2 concentrations of 0.5 and 2 mM of lithium. The vasorelaxation response to sodium nitroprusside, the NO donor, was not different among lithium groups (0.5 and 2 mM) and controls. In conclusion, there is a dual modulation of endothelium-dependent relaxation, including an inhibitory effect at lower dose and a stimulating effect at higher dose of lithium in rat mesenteric vascular bed. NO synthesis or cyclooxygenase inhibition decreased vasorelaxation in both lower and higher doses of lithium, suggesting a role for NO and prostaglandin in this effect. 相似文献
102.
Togha M Mansoureh T Rahmat Jirde M Nilavari K Ashrafian H Razeghi S Kohan L 《The journal of headache and pain》2008,9(2):77-82
This was a double-blind clinical trial designed to assess the efficacy and safety of the cinnarizine (CIN) in patients with
migraine who were refractory to propranolol and tricyclic antidepressants in comparison with sodium valproate (SV) to investigate
whether CIN could be at least as effective as SV. A total of 125 patients were treated in a treatment period of 12 weeks.
All patients had at least one intake of trial medication and 2-week post baseline efficacy observation which all were included
in the ITT analysis. Of the 125 subjects treated, 46 discontinued prematurely: 25 from the CIN and 21 from the SV group. The
main reasons for premature discontinuation were: lost to follow up (25/46, 63.2%), insufficient response (16/46, 20%), and
adverse events (5/46, 12.8%). No statistically significant inter-group differences in the number of discontinuation was observed
(p > 0.05). In both groups, number of attacks, intensity, and duration of attacks significantly decreased (p < 0.05). No statistically significant inter-group differences were observed regarding the mean number of attacks, duration,
and intensity of migraine attacks for any of the time intervals analysed, except for the mean reduction of third and fourth
visits intensity from baseline which were significantly different in two groups (p < 0.05), with the CIN group showing more reduction. Analysis of the number of responders showed that in the CIN group 61.2%
subjects were responders, and 63.8% in the SV group. No statistically significant differences between the treatment groups
were found for any of the secondary parameters. Overall 26 subjects reported one or more adverse events during the study period:
13 subjects in each group. Five subjects discontinued prematurely due to adverse events; two in the CIN group with significant
weight gain, and 3 in the SV group with significant weight gain and severe tremor. These results suggest that CIN is an effective
and safe prophylactic agent even in severe migraine headache.
An erratum to this article can be found at 相似文献
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105.
Dachman AH; Lieberman J; Osnis RB; Chen SY; Hoffmann KR; Chen CT; Newmark GM; McGill J 《Radiology》1997,203(2):427
106.
107.
Durdi Qujeq Behzad Hidari Khezroolla Bijani Hosein Shirdel 《Clinical chemistry and laboratory medicine》2003,41(2):200-202
Serum glutathione peroxidase (GSH-Px) activity and selenium concentration were compared in intrinsic asthmatic patients and non-asthmatic control subjects. Serum GSH-Px activity and selenium concentration were assessed in 46 asthmatic patients and 75 age- and sex-matched non-asthmatic subjects by spectrophotometric assay. Mean serum GSH-Px activity was lower in intrinsic asthmatic subjects (9.4 +/- 2.6 pmol NADPH oxidized/min/g of protein) than in non-asthmatic subjects (16.3 +/- 2.9 pmol NADPH oxidized/min/g of protein). Mean serum selenium was lower in intrinsic asthmatic subjects (1.15 +/- 0.23 microM) than in non-asthmatic subjects (1.98 +/- 0.27 microM). Asthmatic patients have significantly lower concentration of selenium and GSH-Px activity measured in serum. 相似文献
108.
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110.
CT guidance for percutaneous gastrostomy and gastroenterostomy 总被引:2,自引:0,他引:2
Sanchez RB; vanSonnenberg E; D'Agostino HB; Goodacre BW; Moyers P; Casola G 《Radiology》1992,184(1):201