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101.
102.
125I粒子对Hela细胞杀伤作用的实验研究 总被引:2,自引:0,他引:2
目的观察体外Hela细胞在^125I粒子照射下细胞凋亡和增殖的规律,探讨^125I粒子对肿瘤的杀伤作用。方法用^125I粒子照射Hela细胞,用不同的方法观察不同剂量和时间点细胞的增殖反应及形态变化。结果受照射细胞发生凋亡,于Ⅱb期出现凋亡小体;细胞凋亡率随累积剂量的增加而增加,于5Gy时出现凋亡率峰值;细胞克隆形成率显著下降,与凋亡形成呈反向关系。并有反剂量率效应。结论^125I粒子对肿瘤的治疗作用可能为早期抑制肿瘤细胞增殖,晚期使肿瘤细胞大量凋亡。 相似文献
103.
Trabecular bone architecture in female renal allograft recipients-- assessed by computed tomography 总被引:1,自引:0,他引:1
Grotz WH; Mundinger FA; Muller CB; Rasenack J; Schulte-Monting J; Langer MF; Schollmeyer PJ 《Nephrology, dialysis, transplantation》1997,12(3):564-569
BACKGROUND: Osteopenia with decreased bone mineral density (BMD) is a
frequent finding in renal allograft recipients. Data concerning the bone
architecture in these patients do not exist, however. METHODS: We compared
the bone architecture of 33 randomly assigned women (age 49 +/- 12 years),
who had received renal allografts 5.6 +/- 5.3 years before the
investigation, with 74 women (age 50 +/- 14 years) who were admitted for
osteodensitometry. All patients underwent single-energy computed tomography
(SEQCT) and a midvertebral high-resolution tomography with
computer-assisted analysis of the trabecular vertebral body architecture.
RESULTS: Progressive alteration of bone architecture was associated with
increasing vertebral height loss of the vertebral body. Height reduction of
a vertebral body of more than 15% was associated with a significantly lower
BMD (-2.3 +/- 0.8 versus -1.1 +/- 1.1 standard deviations below normal
BMD), a lower trabecular bone area (13 +/- 8% versus 42 +/- 22%) and a
lower trabecular diameter (1.4 +/- 0.5 mm versus 2.2 +/- 0.8 mm) compared
to recipients without height reduction. In comparison to a matched group of
patients with similarly reduced BMD (1.1 +/- 1.2 versus 1.2 +/- 1.1 SD
below normal BMD), renal allograft recipients showed a lower number of
trabecular plates (5.6 +/- 3.1 versus 7.0 +/- 3.7) and a smaller
intertrabecular surface (54 +/- 116 mm versus 75 +/- 138 mm). CONCLUSIONS:
Alterations of bone architecture in renal allograft recipients were
associated with progressive vertebral height loss. Despite similar bone
mineral density, differences of bone architecture could be observed between
renal allograft recipients and patients with osteoporosis.
相似文献
104.
105.
The effect of BCG vaccine at birth on the development of atopy or allergic disease in young children. 总被引:3,自引:0,他引:3
R G Townley I B Barlan C Patino P Vichyanond M C Minervini T Simasathien R Nettagul N N Bahceciler D Basdemir T Akkoc S Pongprueksa R J Hopp 《Annals of allergy, asthma & immunology》2004,92(3):350-355
BACKGROUND: Exposure to infectious diseases may reduce the development of asthma or allergy. In particular, the role of the BCG vaccine in modulating asthma or allergy has been a source of speculation. OBJECTIVE: To study newborns from 3 international sites to evaluate the prospective effect of BCG vaccine on allergic diseases or atopic development. METHODS: Infants were enrolled from newborn and well-infant clinics in Thailand, Argentina, and Turkey. The standard BCG vaccine for each country was given at birth. Parents who consented to have their infant included in the protocol completed an allergy family questionnaire. Infants underwent a standard purified protein derivative (PPD) test at 9 to 12 months of age, and the reaction size was measured. At the age of 2 years, the children returned to be studied. Allergy skin tests to common allergens appropriate to location and age were performed, and the parents completed the International Study of Allergy and Asthma in Childhood questionnaire. The PPD reaction size was compared with the presence of atopy and allergy questionnaire responses. RESULTS: A total of 1,704 infants were studied. Statistical significance was found between a negative PPD response vs any positive PPD response and the risk of having an allergic history at the age of 2 years in Turkey (relative risk, 2.11; 95% confidence interval, 1.25-3.55; P = .005) and Thailand (relative risk, 2.16; 95% confidence interval, 1.18-3.94; P = .02) but not Argentina (relative risk, 1.09; 95% confidence interval, 0.70-1.68; P = .70). CONCLUSIONS: This study further supports the role of infectious agents in modulating asthma and allergy development. 相似文献
106.
107.
目的 探究食管支架置入术(ESP)和内镜下切开术(EIM)在难治性食管癌术后吻合口狭窄治疗中的应用效果.方法 将70例难治性食管癌术后吻合口狭窄患者按照手术方式不同分为ESP组(n=41)与EIM组(n=29).对比两组患者临床疗效、吞咽困难评分及并发症发生情况.结果 两组患者总有效率比较,差异无统计学意义(P>0.05).术前,两组患者Stooler评分比较,差异无统计学意义(P>0.05);术后1个月,两组患者Stooler评分均较术前降低(P<0.05),且EIM组患者Stooler评分明显低于ESP组(P<0.01).ESP组患者术后并发症总发生率高于EIM组(P<0.05).结论 EIM和ESP治疗难治性食管癌吻合口狭窄的临床疗效相当,EIM短期内对患者吞咽困难症状改善作用明显,且具有术后并发症少等优点. 相似文献
108.
Long‐term efficacy and safety of oxycodone‐naloxone prolonged‐release formulation (up to 180/90 mg daily) – results of the open‐label extension phase of a phase III multicenter,multiple‐dose,randomized, controlled study
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D. Dupoiron A. Stachowiak O. Loewenstein A. Ellery W. Kremers B. Bosse M. Hopp 《European Journal of Pain》2017,21(9):1485-1494
109.
110.
A. Krumholz S. Wiebe G. S. Gronseth D. S. Gloss A. M. Sanchez A. A. Kabir A. T. Liferidge J. P. Martello A. M. Kanner S. Shinnar J. L. Hopp J. A. French 《Epilepsy Currents》2015,15(3):144-152
OBJECTIVE: To provide evidence-based recommendations for treatment of adults with an unprovoked first seizure. METHODS: We defined relevant questions and systematically reviewed published studies according to the American Academy of Neurology''s classification of evidence criteria; we based recommendations on evidence level. RESULTS AND RECOMMENDATIONS: Adults with an unprovoked first seizure should be informed that their seizure recurrence risk is greatest early within the first 2 years (21%–45%) (Level A), and clinical variables associated with increased risk may include a prior brain insult (Level A), an EEG with epileptiform abnormalities (Level A), a significant brain-imaging abnormality (Level B), and a nocturnal seizure (Level B). Immediate antiepileptic drug (AED) therapy, as compared with delay of treatment pending a second seizure, is likely to reduce recurrence risk within the first 2 years (Level B) but may not improve quality of life (Level C). Over a longer term (> 3 years), immediate AED treatment is unlikely to improve prognosis as measured by sustained seizure remission (Level B). Patients should be advised that risk for AED adverse events (AEs) may range from 7%–31% (Level B) and that these AEs are likely predominantly mild and reversible. Clinicians'' recommendations whether to initiate immediate AED treatment after a first seizure should be based on individualized assessments that weigh the risk of recurrence against the AEs of AED therapy, consider educated patient preferences, and advise that immediate treatment will not improve the long-term prognosis for seizure remission but will reduce seizure risk over the subsequent 2 years. 相似文献