全文获取类型
收费全文 | 11356篇 |
免费 | 1126篇 |
国内免费 | 839篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 139篇 |
妇产科学 | 78篇 |
基础医学 | 1383篇 |
口腔科学 | 128篇 |
临床医学 | 1369篇 |
内科学 | 1627篇 |
皮肤病学 | 110篇 |
神经病学 | 584篇 |
特种医学 | 382篇 |
外国民族医学 | 7篇 |
外科学 | 1239篇 |
综合类 | 2276篇 |
现状与发展 | 2篇 |
一般理论 | 1篇 |
预防医学 | 831篇 |
眼科学 | 225篇 |
药学 | 1209篇 |
6篇 | |
中国医学 | 722篇 |
肿瘤学 | 938篇 |
出版年
2024年 | 37篇 |
2023年 | 160篇 |
2022年 | 413篇 |
2021年 | 498篇 |
2020年 | 384篇 |
2019年 | 417篇 |
2018年 | 407篇 |
2017年 | 338篇 |
2016年 | 332篇 |
2015年 | 447篇 |
2014年 | 579篇 |
2013年 | 560篇 |
2012年 | 723篇 |
2011年 | 814篇 |
2010年 | 563篇 |
2009年 | 405篇 |
2008年 | 450篇 |
2007年 | 533篇 |
2006年 | 542篇 |
2005年 | 501篇 |
2004年 | 487篇 |
2003年 | 656篇 |
2002年 | 610篇 |
2001年 | 512篇 |
2000年 | 366篇 |
1999年 | 324篇 |
1998年 | 167篇 |
1997年 | 170篇 |
1996年 | 120篇 |
1995年 | 121篇 |
1994年 | 111篇 |
1993年 | 85篇 |
1992年 | 80篇 |
1991年 | 82篇 |
1990年 | 67篇 |
1989年 | 54篇 |
1988年 | 52篇 |
1987年 | 42篇 |
1986年 | 39篇 |
1985年 | 24篇 |
1984年 | 13篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 10篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1968年 | 1篇 |
1966年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
Jiansen Gong Chengming Wang Shourong Shi Hongduo Bao Chunhong Zhu Patrick Kelly Linlin Zhuang Guangwu Lu Xinhong Dou Ran Wang Bu Xu Jianmin Zou 《Antimicrobial agents and chemotherapy》2016,60(3):1943-1947
Highly drug-resistant Salmonella enterica serovar Indiana became the most common serovar in broilers with diarrhea in China over the course of this study (15% in 2010 to 70% in 2014). While most S. Indiana isolates (87%, 384/440) were resistant to 13 to 16 of the 16 antibiotics tested, 89% of non-S. Indiana isolates (528/595) were resistant to 0 to 6 antibiotics. Class 1 integrons and IncHI2-type plasmids were detected in all S. Indiana isolates, but only in 39% and 1% of non-S. Indiana isolates. 相似文献
992.
Jiang D Liang J Hodge J Lu B Zhu Z Yu S Fan J Gao Y Yin Z Homer R Gerard C Noble PW 《The Journal of clinical investigation》2004,114(2):291-299
CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-gamma-inducible C-X-C chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on activated immune cells and proliferating endothelial cells. The role of CXCR3 in fibroproliferation has not been investigated. We examined the role of CXCR3 in pulmonary injury and repair in vivo. CXCR3-deficient mice demonstrated increased mortality with progressive interstitial fibrosis relative to WT mice. Increased fibrosis occurred without increased inflammatory cell recruitment. CXCR3 deficiency resulted in both a reduced early burst of IFN-gamma production and decreased expression of CXCL10 after lung injury. We identified a relative deficiency in lung NK cells in the unchallenged CXCR3-deficient lung and demonstrated production of IFN-gamma by WT lung NK cells in vivo following lung injury. The fibrotic phenotype in the CXCR3-deficient mice was significantly reversed following administration of exogenous IFN-gamma or restoration of endogenous IFN-gamma production by adoptive transfer of WT lymph node and spleen cells. Finally, pretreatment of WT mice with IFN-gamma-neutralizing Ab's enhanced fibrosis following lung injury. These data demonstrate a nonredundant role for CXCR3 in limiting tissue fibroproliferation and suggest that this effect may be mediated, in part, by the innate production of IFN-gamma following lung injury. 相似文献
993.
994.
目的研究急性病毒性肝炎(AVH)患者胆囊(GB)排空功能及其与病情程度和转归的关系.方法用实时超声研究了32例AVH患者及26例健康对照者GB排空功能.结果空腹GB容量(FGV)AVH患者(1022±231)明显小于对照组(1979±151)(P<0001),随病程延长,FGV渐增多.FGV减少与病情程度呈显著负相关(P<005).餐后GB排出量(GEF)AVH组显著少于对照组(P<0001),其减少与病情程度呈明显负相关(P<001),与血清胆红质、ALT水平呈显著负相关(P<005~001).60min最大GEF及GB排空速度明显减少、减慢(P<0001).恢复期FGV及餐后GEF均恢复正常.结论AVH患者存在FGV和餐后GEF异常.其机制与肝细胞损害,泌胆功能障碍及神经—激素调控失调有关. 相似文献
995.
Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice 总被引:6,自引:0,他引:6
Yu XX Murray SF Pandey SK Booten SL Bao D Song XZ Kelly S Chen S McKay R Monia BP Bhanot S 《Hepatology (Baltimore, Md.)》2005,42(2):362-371
In this study, we investigated the role of acyl-coenzyme A:diacylglycerol acyltransferase 2 (DGAT2) in glucose and lipid metabolism in obese mice by reducing its expression in liver and fat with an optimized antisense oligonucleotide (ASO). High-fat diet-induced obese (DIO) C57BL/6J mice and ob/ob mice were treated with DGAT2 ASO, control ASO, or saline. DGAT2 ASO treatment reduced DGAT2 messenger RNA (mRNA) levels by more than 75% in both liver and fat but did not change DGAT1 mRNA levels in either of these tissues, which resulted in decreased DGAT activity in liver but not in fat. DGAT2 ASO treatment did not cause significant changes in body weight, adiposity, metabolic rate, insulin sensitivity, or skin microstructure. However, DGAT2 ASO treatment caused a marked reduction in hepatic triglyceride content and improved hepatic steatosis in both models, which was consistent with a dramatic decrease in triglyceride synthesis and an increase in fatty acid oxidation observed in primary mouse hepatocytes treated with DGAT2 ASO. In addition, the treatment lowered hepatic triglyceride secretion rate and plasma triglyceride levels, and improved plasma lipoprotein profile in DIO mice. The positive effects of the DGAT2 ASO were accompanied by a reduction in the mRNA levels of several hepatic lipogenic genes, including SCD1, FAS, ACC1, ACC2, ATP-citrate lyase, glycerol kinase, and HMG-CoA reductase. In conclusion, reduction of DGAT2 expression in obese animals can reduce hepatic lipogenesis and hepatic steatosis as well as attenuate hyperlipidemia, thereby leading to an improvement in metabolic syndrome. 相似文献
996.
7个少数民族血清7种元素与血压关系的研究 总被引:1,自引:0,他引:1
采用原子吸收和火焰光谱分析法,检测我国7个少数民族脑中风病危人群血清微量元素Zn,Cu,Fe和常量元素K,Na,Ca,Mg的含量,并与血压的关系进行分析。结果发现高血压病高发区人群血清Na,Mg,Zn,Fe,Na/K,Zn/Cu明显高于低发区和对照组,而K,Ca,Cu,Ca/Mg则明显低于低发区和对照组。K,Ca,Cu,Ca/Mg与血压呈显著负相关,而Zn,Fe,Na/K与血压呈显著正相关。提示Fe,Na,Zn,Ca的含量变化与血压有密切的关系。 相似文献
997.
Lan‐Juan Zhao Xiao‐Gang Liu Yao‐Zhong Liu Yong‐Jun Liu Christopher J Papasian Bao‐Yong Sha Feng Pan Yan‐Fang Guo Liang Wang Han Yan Dong‐Hai Xiong Zi‐Hui Tang Tie‐Lin Yang Xiang‐Ding Chen Yan Guo Jian Li Hui Shen Feng Zhang Shu‐Feng Lei Robert R Recker Hong‐Wen Deng 《Journal of bone and mineral research》2010,25(2):320-329
Poor femoral neck bone geometry at the femur is an important risk factor for hip fracture. We conducted a genome‐wide association study (GWAS) of femoral neck bone geometry, examining approximately 379,000 eligible single‐nucleotide polymorphisms (SNPs) in 1000 Caucasians. A common genetic variant, rs7430431 in the receptor transporting protein 3 (RTP3) gene, was identified in strong association with the buckling ratio (BR, P = 1.6 × 10?7), an index of bone structural instability, and with femoral cortical thickness (CT, P = 1.9 × 10?6). The RTP3 gene is located in 3p21.31, a region that we found to be linked with CT (LOD = 2.19, P = 6.0 × 10?4) in 3998 individuals from 434 pedigrees. The replication analyses in 1488 independent Caucasians and 2118 Chinese confirmed the association of rs7430431 to BR and CT (combined P = 7.0 × 10?3 for BR and P = 1.4 × 10?2 for CT). In addition, 350 hip fracture patients and 350 healthy control individuals were genotyped to assess the association of the RTP3 gene with the risk of hip fracture. Significant association between a nearby common SNP, rs10514713 of the RTP3 gene, and hip fracture (P = 1.0 × 10?3) was found. Our observations suggest that RTP3 may be a novel candidate gene for femoral neck bone geometry. © 2010 American Society for Bone and Mineral Research 相似文献
998.
999.
Bao F Panarelli NC Rennert H Sherr DL Yantiss RK 《The American journal of surgical pathology》2010,34(12):1798-1804
Immunohistochemical stains are routinely used to detect abnormal DNA mismatch repair (MMR) protein expression in colorectal carcinomas, particularly when Lynch syndrome is suspected. Complete loss of MMR protein expression is often associated with underlying microsatellite instability (MSI), and the combined results of mutL homolog 1 (MLH1), postmeiotic segregation increased 2 (PMS2), mutS homolog 2 (MSH2), or mutS homolog 6 (MSH6) immunostains may point to the defective MMR protein in tumors with MSI. We have noted that some neoadjuvantly treated colorectal carcinomas display loss of MMR protein immunoexpression, despite a lack of underlying MSI and preserved staining in pretreatment tumor samples. The purpose of this study was to determine the frequency of this finding. We identified 51 neoadjuvantly treated resected colorectal cancers. Posttreatment tumor samples were immunohistochemically stained with MLH1, PMS2, MSH2, and MSH6 antibodies. Loss of staining for any marker was followed by analysis for MSI and assessment of MMR protein expression in pretreatment tumor samples. All of the 51 posttreatment tumor samples showed preserved MLH1, PMS2, and MSH2, but 10 posttreatment tumor samples (20%) showed decreased MSH6 staining. Of these, 9 posttreatment tumor samples displayed loss of staining in less than 100% of tumor cells, but preserved MSH6 expression in pretreatment tumor samples. One case showed a complete absence of MSH6 staining in both pretreatment and posttreatment tumor samples. All 10 cases were microsatellite stable. We conclude that extensive loss of MSH6 immunoexpression is common among neoadjuvantly treated colorectal carcinomas, but generally does not reflect underlying MSI. Therefore, diminished MSH6 staining in treated tumors should prompt immunohistochemical evaluation of pretreatment biopsy samples before genetic testing for Lynch syndrome. 相似文献