全文获取类型
收费全文 | 127594篇 |
免费 | 14926篇 |
国内免费 | 6072篇 |
专业分类
耳鼻咽喉 | 1583篇 |
儿科学 | 2317篇 |
妇产科学 | 1654篇 |
基础医学 | 11114篇 |
口腔科学 | 4499篇 |
临床医学 | 17652篇 |
内科学 | 18971篇 |
皮肤病学 | 2064篇 |
神经病学 | 6391篇 |
特种医学 | 5068篇 |
外国民族医学 | 26篇 |
外科学 | 13032篇 |
综合类 | 21422篇 |
现状与发展 | 35篇 |
一般理论 | 7篇 |
预防医学 | 12614篇 |
眼科学 | 2670篇 |
药学 | 11724篇 |
82篇 | |
中国医学 | 6235篇 |
肿瘤学 | 9432篇 |
出版年
2024年 | 376篇 |
2023年 | 2018篇 |
2022年 | 2838篇 |
2021年 | 4068篇 |
2020年 | 3913篇 |
2019年 | 2762篇 |
2018年 | 3735篇 |
2017年 | 3884篇 |
2016年 | 4156篇 |
2015年 | 5777篇 |
2014年 | 7490篇 |
2013年 | 8400篇 |
2012年 | 9570篇 |
2011年 | 10067篇 |
2010年 | 8687篇 |
2009年 | 8321篇 |
2008年 | 8133篇 |
2007年 | 7842篇 |
2006年 | 7453篇 |
2005年 | 6526篇 |
2004年 | 5108篇 |
2003年 | 5215篇 |
2002年 | 4132篇 |
2001年 | 3477篇 |
2000年 | 2683篇 |
1999年 | 1978篇 |
1998年 | 1375篇 |
1997年 | 1414篇 |
1996年 | 1153篇 |
1995年 | 927篇 |
1994年 | 756篇 |
1993年 | 567篇 |
1992年 | 517篇 |
1991年 | 440篇 |
1990年 | 389篇 |
1989年 | 347篇 |
1988年 | 297篇 |
1987年 | 278篇 |
1986年 | 215篇 |
1985年 | 212篇 |
1984年 | 145篇 |
1983年 | 142篇 |
1982年 | 120篇 |
1981年 | 97篇 |
1980年 | 65篇 |
1979年 | 69篇 |
1978年 | 66篇 |
1977年 | 54篇 |
1976年 | 54篇 |
1973年 | 43篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Edward R. Westrick MS Allan P. Shapiro PhD Peter E. Nathan PhD John Brick PhD 《Alcoholism, clinical and experimental research》1988,12(4):531-533
The present study demonstrates that alcohol-induced memory impairment can be attenuated by pretreatment with an oral tryptophan supplementation. These results provide support for the role of a brain serotonin deficit in this impairment and highlight the impact a dietary manipulation can have on a complex behavioral process. 相似文献
92.
Most prosthetic joint infections (PJI) are due to wound contamination at the time of surgery. Some infections occur due to the hematogenous spread of bacteria from distant sites of infection. A review of the literature fails to associate PJI with transient bacteremias from invasive dental procedures. Several authors have described conditions which, they believe, render patients with prosthetic joints more at risk for infection. Prosthetic joint patients with these "high risk" conditions have the same types of infecting organisms as other patients with PJI. This indicates that the infecting bacteria are from wound contamination or distant sites of infection and not related to dental procedure bacteremias. Based on this review, antibiotic prophylaxis is not indicated for patients with prosthetic joints when receiving invasive dental procedures, since there is no proven benefit and there are known risks involved with the use of antibiotics. However, the American Dental Association (ADA) and the American Academy of Orthopaedic Surgeons (AAOS), in an advisory statement, suggest prophylaxis for "high risk" patients. The ADA and AAOS recommend a single dose of amoxicillin, cephradine, or clindamycin when prophylaxis is selected. The dentist is ultimately responsible for making treatment recommendations for his or her patients. 相似文献
93.
94.
MR compatibility of Guglielmi detachable coils 总被引:6,自引:0,他引:6
95.
96.
L-丙酰肉碱对再灌注心肌损伤的保护及体外抗自由基作用 总被引:1,自引:0,他引:1
目的:观察L-丙酰肉碱对缺血再灌注心肌的保护作用,并探讨其机理。方法:采用大鼠在体心脏冠状动脉前降支阻断5min造成缺血再灌注模型,持续心电监护,观察心律失常与心功能指标;应用电子顺磁共振观察L-丙酰肉碱对Fenton体系及二甲基亚砜(DMSO)碱性有氧体系产生自由基的作用。结果:L-丙酰肉碱静脉给药明显减少再灌注时室性心动过速、室性纤维颤动的发生(P<0.05),促进再灌注后左室收缩压、左室压最大上升速率、左室压最大下降速率、心力环面积的恢复,与对照组相比,各参数均明显增高(P<0.05);静脉注射L-丙酰肉碱100mmol/L时促进Fenton体系OH的产生,而500mmol/L时产生明显抑制作用,L-丙酰肉碱明显抑制DMSO碱性有氧体系OS的产生。结论:L-丙酰肉碱明显减少再灌注心律失常的发生,促进再灌注后心功能的恢复。推测它对自由基的作用可能是再灌注损伤保护机理之一。 相似文献
97.
98.
Summary— KR31080 (2-butyl-5-methyl-6-(1-oxopyridin-2-yl)-3-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-3H-imidazo[4,5-b] pyridine) is a potent inhibitor of angiotensin type 1 (AT1 ) receptors in rabbit aorta and human recombinant AT1 receptors. In the isolated rabbit thoracic aorta, KR31080 caused a nonparallel shift to the right of the concentration-response curves to angiotensin II (All) with decreased maximal response (pD'2 = 10.1 ± 0.1), but had no effect on the contractile response induced by norepinephrine. KR31080 inhibited specific [125 I]AII binding to rabbit aortic membranes (AT, receptors) and [125 I][Sar1 , Ile8 ]AII binding to human recombinant AT1 receptors in a concentration-dependent manner with IC50 values of 0.84 ± 0.08 nM and 1.92 ± 0.15 nM, respectively, but did not inhibit specific [125 I)AII binding to bovine cerebellum membranes (ÀT2 receptors). In the Scatchard analysis, KR31080 interacted with rabbit aortic AT1 receptors in a competitive manner, similar to losartan. These results demonstrate that KR31080 is a potent and AT1 selective angiotensin receptor antagonist which exerts a competitive antagonism in the [125 I]AII binding assay and insurmountable AT1 receptor antagonism in the functional study. 相似文献
99.
A Decade of Change in Obesity Surgery 总被引:4,自引:0,他引:4
Edward E Mason MD PhD Shenghui Tang MS Kathleen E Renquist BS Dwight T Barnes Joseph J Cullen MD Cornelius Doherty MD James W Maher MD 《Obesity surgery》1997,7(3):189-197
Background: The International (formerly National) Bariatric Surgery Registry began collecting data in January 1986. The aim
of this study was to examine changes in the practice of surgical treatment of severe obesity that occurred during the decade
of 1986 through 1995, as observed in the IBSR data. Methods: All data submitted to the IBSR during the decade were transferred
to the IBM mainframe computer for analysis. Characteristics of operative type populations were compared over time using analysis
of variance (ANOVA) for age, body mass index (BMI), operative weight and Chi-square (χ2) test for gender. Results: There has been a steady increase over the decade in mean patient weight. The operations used have
changed from predominantly ‘simple’ operations to more frequent use of ‘complex’ operations. Within the categories of ‘simple’
and ‘complex’, an increase in the variety of operations occurred. As a group, patients with ‘simple’ operations have been
heavier, more often male and public pay patients than those who have undergone ‘complex’ operations. One year weight loss
was greater for Roux-en-Y gastric bypass (RGB) than vertical banded gastroplasty (VBG), but follow-up rates were too low to
study the relative merits of the operations used. The reported incidence of operative mortality and serious complications
(leak with peritonitis, abscess and pulmonary embolism) remained low. Conclusions: These observations and their implications
can be summarized in three statements which relate to action for improved patient care in the beginning of the new century:
(1) increasing weight of candidates for surgical treatment during this decade indicates the need for earlier use of operative
treatment before irreversible complications of obesity can develop; (2) low risk of obesity surgery, decreasing postoperative
hospital stay, and early weight control support the continued and increased use of surgical treatment; (3) continued widespread
use of both ‘simple’ and ‘complex’ operations with increased modifications of standard RGB and VBG procedures emphasizes the
need for standardized long-term data and analyses regarding both weight control and postoperative side-effects. 相似文献
100.
本文选择34颗有银汞充填体悬突的患牙,采用金刚砂钻和银汞磨光钻去除悬突,并观察去除悬突前后部分牙周组织的变化、结果表明银汞充填体悬突危害牙周组织的健康.去除悬突并协同口腔卫生宣教、可促进牙周组织的恢复. 相似文献