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991.
Hilbrands L Hoitsma A Wetzels J 《The New England journal of medicine》2005,352(19):2027-8; author reply 2027-8
992.
993.
RJ Postlethwaite DM Eminson JM Reynolds AJ Wood S Hollis 《Archives of disease in childhood》1998,78(3):222-229
Growth and psychological functioning were studied in 30 patients with renal failure over a two year period following the offer of growth hormone treatment for significant short stature. Parents' concerns about growth decreased significantly during the study. Twenty eight parents (93%) accepted growth hormone treatment; most (74%) were satisfied with it and would opt for it again (89%). The views of these parents were unrelated to growth outcome in their child. This suggests that the positive responses were related more to the effort to improve growth than to any objective treatment success. In contrast children's reduction in concern about growth, satisfaction with treatment (36%), and decision to opt for growth hormone again (50%) were all significantly related to improvement in growth. Parents' reports of non-compliance increased significantly from 41% at 1 year to 91% at 2 years in the group as a whole. No significant changes were identified in maternal mental distress and no additional costs to the psychological health of the children seem to have resulted from the introduction of growth hormone treatment. A group of children was identified who accepted treatment but had continued poor growth. These appeared to be at particular risk of both physical problems and associated or consequent psychological difficulties. 相似文献
994.
Three babies were referred with enteroviral meningitis and myocarditis during a 4-month period. During this same period there was an increased frequency of coxsackievirus B type 2 isolates reported to the National Centre for Disease Control. Myocarditis was simultaneous with meningitis in one baby, but delayed by 10 weeks in another, in whom myocarditis mimicked myocardial infarction. Two of the three mothers experienced abdominal pain, one with antepartum haemorrhage, which has been described previously with coxsackievirus infection in pregnancy. Diagnosis was made in two babies by polymerase chain reaction on cerebrospinal fluid. 相似文献
995.
996.
Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays 总被引:1,自引:0,他引:1
van der Houven van Oordt CW; Smits R; Williamson SL; Luz A; Khan PM; Fodde R; van der Eb AJ; Breuer ML 《Carcinogenesis》1997,18(11):2197-2203
Seven-week-old Apc1638N mice were exposed to a single dose of 5 Gy
total-body X-irradiation resulting in a 8-fold increase in the number of
intestinal tumors and a reduction of the lifespan to an average of 6
months. The distribution of tumors along the intestinal tract as well as
the adenoma/carcinoma ratio, were similar between non-irradiated and
irradiated animals. Semi-quantitative PCR analysis of intestinal-tumor DNA
revealed that 10 out of 14 tumors had lost the wild-type Apc allele.
However, in contrast to spontaneous Apc1638N intestinal tumors in which the
LOH event at the Apc locus involves the entire chromosome 18 (1), in 6 out
of 10 tumors derived from X-irradiated animals the Apc loss is associated
with only a partial intrachromosomal deletion. The remaining tumors have
lost all chromosome 18 markers tested. In addition to the intestinal
tumors, female Apc1638N mice are susceptible to the development of mammary
tumors. Upon X-irradiation, Apc1638N mice show a striking 15-fold increase
in mammary tumors. Moreover, Apc1638N mice spontaneously develop other
extra-intestinal neoplasia, such as desmoid-like lesions similar to those
associated with familial adenomatous polyposis (FAP), the human syndrome
caused by germline mutations in the APC gene. Spontaneous desmoid growth is
sex-dependent, as male Apc1638N mice develop 3-fold more desmoids than
female mice. Interestingly, X-irradiation seemed to increase the number of
desmoids per animal nearly twofold only in female Apc1638N mice. Five out
of 9 desmoids found in Apc1638N mice exposed to X-ray displayed loss of the
wild-type Apc allele.
相似文献
997.
Common <Emphasis Type="Italic">ERBB2</Emphasis> polymorphisms and risk of breast cancer in a white British population: a case–control study 下载免费PDF全文
Patrick?R?BenusiglioEmail author Fabienne?Lesueur Craig?Luccarini Donald?M?Conroy Mitul?Shah Douglas?F?Easton Nick?E?Day Alison?M?Dunning Paul?D?Pharoah Bruce?AJ?Ponder 《Breast cancer research : BCR》2004,7(2):R204
Introduction
About two-thirds of the excess familial risk associated with breast cancer is still unaccounted for and may be explained by multiple weakly predisposing alleles. A gene thought to be involved in low-level predisposition to the disease is ERBB2 (HER2). This gene is involved in cell division, differentiation, and apoptosis and is frequently amplified in breast tumours. Its amplification correlates with poor prognosis. Moreover, the coding polymorphism I655V has previously been associated with an increased risk of breast cancer. 相似文献998.
Transient osteoporosis: transient bone marrow edema? 总被引:13,自引:0,他引:13
Ten patients with debilitating hip or knee pain were examined with magnetic resonance (MR) imaging. All had conventional radiographs that were either normal or showed nonspecific osteopenia. Nine patients had bone scintigrams that showed focal increased radionuclide uptake in the region of the painful joint. In each case, MR images of the affected joint showed regional decreased signal intensity of the bone marrow on T1-weighted images and increased signal intensity on T2-weighted images. Biopsy results of four patients excluded ischemic necrosis and metastases. The symptoms resolved spontaneously in all cases. The ten patients were followed up for 12-36 months, and there were no recurrences. The authors believe that the findings on MR images represent a transient increase in bone marrow water content. The focal findings on scintigrams confirmed the periarticular distribution of the process and provided evidence of accompanying hyperemia and increased bone mineral metabolism. For lack of a better term and to emphasize the generic character of the condition, the authors termed this condition "the transient marrow edema syndrome." 相似文献
999.
1000.
RS Procianoy JA Garcia-Prats JM Adams A Silvers AJ Rudolph 《Archives of disease in childhood》1980,55(7):502-505
19 small for gestational age (SGA) infants with gestational ages less than or equal to 32 weeks were matched with 19 appropriate for gestational age (AGA) preterm neonates with similar risk factors for intraventricular haemorrhage and hyaline membrane disease. Gestational age, 1- and 5-minute Apgar scores, type of delivery, survival rate, use of corticosteroids before delivery, sex, twinning, presence of premature rupture of membranes, and birth date were comparable in the two groups. Gestational age of both groups was 30 (+/- 1.8) weeks, and birthweights were 919 (+/- 202) g (SGA group) and 1268 (+/- 212) g (AGA group). The incidences of hyaline membrane disease and intraventricular haemorrhage were different: 74 and 42% respectively for AGA neonates, 5 and 11% respectively for SGA infants. We suggest that a stressful environment in utero may enhance maturation and prevent hyaline membrane disease and intraventricular haemorrhage. 相似文献