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991.
Takeru Wakatsuki Katsutoshi Obara Atsushi Irisawa Hiroaki Sakamoto Toshimitu Kuwana Fujio Takiguchi Ayako Saito Hideo Shishido Takuto Hikichi Hitoshi Oyama Goro Shibukawa Tadayuki Takagi Go Yamamoto Hidemichi Imamura Yuta Takahashi Ai Sato Masaki Sato Reiji Kasukawa Hiromasa Ohira 《Digestive endoscopy》2009,21(4):232-238
Background: The prognostic factors, including gastric variceal bleeding itself, in patients with gastric varices (GV) after endoscopic treatment remain unclear. The aim of this study was to analyze prognostic factors in patients with GV after endoscopic treatment as well as to evaluate safety and efficacy of our endoscopic treatment. Patients and Methods: This study enrolled 115 patients who underwent endoscopic treatment for GV between October 1988 and December 2003 using cyanoacrylate and 5% ethanolamine oleate. Successful hemostasis, recurrence rates, rebleeding rates, survival rates, complications and prognostic factors after the treatment were retrospectively reviewed. Results: Treatment sessions for GV were performed 3.4 ± 2.5 times. All cases, including 14 emergency cases, were treated successfully. The cumulative recurrence rates at 1, 3 and 5 years after the treatment were 7.0%, 15.6% and 20.0%, respectively, and the cumulative rebleeding rates at 1, 3 and 5 years were 3.5%, 8.7% and 14.8%, respectively. The overall survival rates were 78.3%, 63.7% and 51.5% at 1, 3 and 5 years, respectively. Grade B or C in Child–Pugh classification, emergency or elective cases, and association with hepatocellular carcinoma were identified as significant negative prognostic factors after endoscopic treatment by multivariate analysis. Although several complications were observed, there was no mortality. Conclusions: Grade B or C in Child–Pugh classification, emergency or elective situation, and association with hepatocellular carcinoma are negative prognostic factors after endoscopic treatment. 相似文献
992.
SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis
Hisanobu Sadakata Hideki Okazawa Takashi Sato Yana Supriatna Hiroshi Ohnishi Shinya Kusakari Yoji Murata Tomokazu Ito Uichi Nishiyama Takashi Minegishi Akihiro Harada Takashi Matozaki 《Genes to cells : devoted to molecular & cellular mechanisms》2009,14(3):295-308
SAP-1 (PTPRH) is a receptor-type protein tyrosine phosphatase (RPTP) with a single catalytic domain in its cytoplasmic region and fibronectin type III-like domains in its extracellular region. The cellular localization and biological functions of this RPTP have remained unknown, however. We now show that mouse SAP-1 mRNA is largely restricted to the gastrointestinal tract and that SAP-1 protein localizes to the microvilli of the brush border in gastrointestinal epithelial cells. The expression of SAP-1 in mouse intestine is minimal during embryonic development but increases markedly after birth. SAP-1-deficient mice manifested no marked changes in morphology of the intestinal epithelium. In contrast, SAP-1 ablation inhibited tumorigenesis in mice with a heterozygous mutation of the adenomatous polyposis coli gene. These results thus suggest that SAP-1 is a microvillus-specific RPTP that regulates intestinal tumorigenesis. 相似文献
993.
Tatsuki Yoshimatsu Daisuke Yoshida Hiroyuki Shimada Taiki Komatsu Atsushi Harada Takao Suzuki 《Geriatrics & Gerontology International》2013,13(2):351-357
Aim: Near‐infrared spectroscopy (NIRS) allows estimation of the percentage of body fat (%BF) regardless of the patient's posture; thus, it is useful for assessment of elderly patients with severe decline of basic activity who cannot hold a standing position. However, the accuracy by which the near‐infrared light emitted from NIRS reflects subcutaneous tissue is unknown. The aim of this study was to assess how correctly NIRS reflects the subcutaneous fat and muscle thickness derived from ultrasonography in community‐dwelling elderly. Methods: A total of 93 community‐dwelling older adults aged 65 years and older were enrolled in this study (mean 75.8 years, 6.7 SD). Participants were assessed according to optical density (OD) measurements by NIRS, subcutaneous fat and muscle thickness by ultrasonography, and muscle strength. Pearson's correlation coefficients were calculated for each sex. Stepwise multiple regression analysis was used to identify factors that contributed to OD for each sex. Results: OD measured at the forearm and thigh were significantly correlated with subcutaneous fat thickness. In stepwise multiple regression analyses, subcutaneous fat thickness was found to be a significant determinant of OD in men (forearm β = −0.37, P = 0.01; thigh β = −0.63, P < 0.001) and women (forearm β = −0.50, P < 0.001; thigh: β = −0.52, P < 0.001). Conclusions: These results suggest that NIRS can appropriately estimate fat‐free mass. By adding other variables to OD as the predictive variable, skeletal muscle mass might be estimated in the elderly population. Geriatr Gerontol Int 2013; 13: 351–357 . 相似文献
994.
Hitoshi YOKOYAMA Haruaki KATO Shinya KOBAYASHI Tomoaki TANABE Teruyuki OGAWA Osamu NISHIZAWA 《Lower urinary tract symptoms.》2011,3(1):55-58
Reconstruction of the obliterated vesicourethral junction is both complex and difficult. Here, we report an innovative method using a mobilized bulbar urethra as a continent valve. Three patients with major problems at the vesicourethral junction underwent continent valve reconstruction. In cases 1 and 2, in which there were problems at the anastomosing site after radical prostatectomy, the bladder wall was closed, wedge resection of the midline pubic bone was performed, and a fully mobilized bulbar urethra was implanted submucosally into the anterior bladder wall. In case 2, augmentation cystoplasty using an ileal segment was required due to the small capacity of the bladder. In case 3, in which there was posterior urethra disruption associated with pelvic fracture, the bulbar urethra was implanted into the bladder wall in the same manner as in cases 1 and 2 without pubectomy. The postoperative follow‐up periods were 48, 36, and 12 months, respectively. In all patients, urinary management was achieved by self‐catheterization postoperatively, and the patients were satisfied with their status. This newly devised continent valve construction using a bulbar urethra is effective for reconstruction of the obliterated vesicourethral junction, which markedly improves patients' quality of life. 相似文献
995.
996.
Naomi Takeichi Sanae Midorikawa Atsushi Watanabe Banyar Than Naing Hideki Tamura Toshiko Wakakuri‐Kano Akira Ishizaki Hitoshi Sugihara Sumiko Nissato Yuria Saito Yuichi Aita Kiyo‐aki Ishii Takehito Igarashi Yasushi Kawakami Hisato Hara Tatsuhiko Ikeda Kazuo Shimizu Shinichi Suzuki Hitoshi Shimano Masashi Kawamoto Takashi Shimada Tsuyoshi Watanabe Shinichi Oikawa Kazuhiro Takekoshi 《Clinical endocrinology》2012,77(5):707-714
997.
998.
Hirokazu Taniguchi Akio Uchiyama Hideki Shinno Hitoshi Abo Saburo Izumi 《Journal of infection and chemotherapy》2010,16(5):350-352
This report presents a case of pulmonary tuberculosis with atypical histopathological manifestations in an immunocompetent
patient. A 37-year-old Japanese man was admitted due to multiple small nodules on chest computed tomography (CT). He was diagnosed
with pulmonary tuberculosis following a culture of acid-fast bacterium from suction sputum specimens obtained by bronchoscopy.
The histopathological findings from video-assisted thoracoscopy revealed small, sporadically organized, and fibrotic lesions
with infiltration of eosinophils, plasma cells, and lymphocytes. The administration of antitubercular drugs eliminated the
abnormal shadows on chest CT. Extreme care must be taken in the diagnosis of a patient with inexplicable histopathological
findings. 相似文献
999.
1000.
Satoki Inoue Ikumi Yamamoto Shinichi Ikeda Masahiko Kawaguchi Tetsuji Kawakami Tadaaki Kirita Hitoshi Furuya 《Journal of anesthesia》2010,24(6):930-931
Masticatory muscle tendon-aponeurosis hyperplasia (MMTAH) is a new disease entity characterized by limited mouth opening due to contracture of the masticatory muscles resulting from hyperplasia of tendons and aponeuroses. The other clinical feature is that the face of the patient with this disease displays a square mandible configuration. Muscle relaxants provide no relief for the limited mouth-opening ability. Anesthesiologists need to suspect difficult airway when patients have limited mouth opening with square mandible configuration. MMTAH can therefore be a possible cause of difficult intubation. 相似文献