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排序方式: 共有571条查询结果,搜索用时 15 毫秒
101.
Daisuke Takabatake Yukiko Kajiwara Shoichiro Ohtani Yoko Itano Mari Yamamoto Shinichiro Kubo Masahiko Ikeda Mina Takahashi Fumikata Hara Kenjiro Aogi Shozo Ohsumi Yutaka Ogasawara Yoshitaka Nishiyama Hajime Hikino Kinya Matsuoka Yuko Takahashi Tadahiko Shien Naruto Taira Hiroyoshi Doihara 《Breast cancer (Tokyo, Japan)》2018,25(6):717-722
Background
Perioperative dose-dense chemotherapy (DDCT) with granulocyte-colony stimulating factor (G-CSF) prophylaxis is a standard treatment for patients with high-risk breast cancer. The approval of this approach in Japan led to the widespread adoption of DDCT, despite limited efficacy and safety data among Japanese patients. We evaluated the efficacy and safety of neoadjuvant DDCT for Japanese patients with breast cancer.Methods
This prospective, multicenter, phase II study evaluated 52 women with operable human epidermal growth factor receptor 2-negative breast cancer and axillary lymph node metastasis. Neoadjuvant DDCT (adriamycin plus cyclophosphamide or epirubicin plus cyclophosphamide followed by paclitaxel) was administrated every 2 weeks with G-CSF support. The study endpoints were the rates of pathological complete response (pCR), febrile neutropenia, treatment completion, toxicities, and the relative dose intensity (RDI).Results
The pCR rate was 21.9% (9/41) and the triple-negative (TN) subtype was significantly associated with a high pCR rate (triple-negative: 53.3% vs. luminal A: 7.7% and luminal B: 0%; p?=?0.003). The treatment completion rate was 80.8% (42/52) and the average RDI was 98.9%. Most adverse events were manageable and tolerable. Six patients (11.5%) developed febrile neutropenia. Grade 3–4 adverse events were slightly more common among older patients (57%) with a low protocol completion rate (≥?65 years: 42.9% vs. <65 years: 86.7%, p?=?0.0062).Conclusion
The pCR rate for DDCT was similar to that of standard chemotherapy, although it was remarkably effective for the TN subtype. DDCT may be feasible for Japanese patients with breast cancer although caution is needed for older patients.102.
Maruyama Mitsunari Yoshizako Takeshi Araki Hisatoshi Yoshida Rika Ando Shinji Nakamura Megumi Kitagaki Hajime 《Cardiovascular and interventional radiology》2018,41(12):1877-1884
CardioVascular and Interventional Radiology - To evaluate the utility of future liver remnant plasma clearance rate of indocyanine green (ICGK-F) for predicting post-hepatectomy liver failure... 相似文献
103.
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Kenji Matsumoto M.D. F.I.C.A. Katsunori Tanaka M.D. Kouji Ohsumi M.D. Makoto Nakamaru M.D. Hideaki Obara M.D. Shinobu Hayashi M.D. Masaki Kitajima M.D. F.A.C.S. 《The International journal of angiology》2000,9(1):20-22
To evaluate the appropriate use of the pararectal retroperitoneal approach (RPA) in abdominal aortic aneurysm (AAA) repair, we retrospectively compared the RPA with the transperitoneal approach (TPA). Fifty-four patients in whom the RPA was used and 92 who had the TPA were included in the study. The mean operating time was 286 minutes with the RPA and 252 minutes with the TPA. Intraoperative blood transfusions were necessary in 9.3% of patients who had the RPA and 16.2% who had the TPA. As assessed by computerized tomographic scanning, the mean size of the postoperative retroperitoneal hematoma was 440 mL in the RPA group and 180 mL in the TPA group. Ileus resolved a mean of 3 days postoperatively in the RPA group and 5 days postoperatively in the TPA group. The mean length of postoperative hospitalization was 21 days in the RPA group and 23 days in the TPA group. Prolonged postoperative ileus occurred in no patients in the RPA group and in three patients in the TPA group. None of the differences in outcomes between the groups were significant. Our findings indicate that, in carefully selected patients, the pararectal RPA is suitable for AAA repair. 相似文献
107.
Daisuke Nakajima Yui Watanabe Akihiro Ohsumi Mauricio Pipkin Manyin Chen Pierre Mordant Takashi Kanou Tomohito Saito Ryan Lam Rafael Coutinho Lindsay Caldarone Stephen Juvet Tereza Martinu Rohin K. Iyer John E. Davies David M. Hwang Thomas K. Waddell Marcelo Cypel Shaf Keshavjee 《The Journal of heart and lung transplantation》2019,38(11):1214-1223
108.
Mina Hikichi Minoru Kidokoro Takeshi Haraguchi Hideo Iba Hisatoshi Shida Hideaki Tahara Takafumi Nakamura 《Molecular therapy》2011,19(6):1107-1115
Vaccinia virus, once widely used for smallpox vaccine, has recently been engineered and used as an oncolytic virus for cancer virotherapy. Their replication has been restricted to tumors by disrupting viral genes and complementing them with products that are found specifically in tumor cells. Here, we show that microRNA (miRNA) regulation also enables tumor-specific viral replication by altering the expression of a targeted viral gene. Since the deletion of viral glycoprotein B5R not only decreases viral pathogenicity but also impairs the oncolytic activity of vaccinia virus, we used miRNA-based gene regulation to suppress B5R expression through let-7a, a miRNA that is downregulated in many tumors. The expression of B5R and the replication of miRNA-regulated vaccinia virus (MRVV) with target sequences complementary to let-7a in the 3′-untranslated region (UTR) of the B5R gene depended on the endogenous expression level of let-7a in the infected cells. Intratumoral administration of MRVV in mice with human cancer xenografts that expressed low levels of let-7a resulted in tumor-specific viral replication and significant tumor regression without side effects, which were observed in the control virus. These results demonstrate that miRNA-based gene regulation is a potentially novel and versatile platform for engineering vaccinia viruses for cancer virotherapy. 相似文献
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Uchida K Yayama T Nakajima H Hirai T Kobayashi S Chen K Guerrero AR Baba H 《Journal of orthopaedic surgery (Hong Kong)》2010,18(3):370-373
Treatment for haemangioma of the spinal cord often results in extensive bony resection that necessitates fusion and/or instrumentation. We report on a 75-year-old man who presented with neuropathic pain and muscle weakness of both lower limbs, secondary to an epidural haemangioma at T11-T12, extending laterally into the neuroforamen. The tumour was resected within the neuroforamen after a partial laminectomy and limited medial foraminotomy at T11-T12, without disruption of the osseous continuity of the pars interarticularis, avoiding spinal stabilisation surgery. 相似文献