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排序方式: 共有1807条查询结果,搜索用时 15 毫秒
41.
Tadashi Shin Yuichi Hiraoka Tokiwa Yamasaki Jamey D. Marth Josef M. Penninger Masami Kanai-Azuma Kohichi Tanaka Satoshi Kofuji Hiroshi Nishina 《Genes to cells : devoted to molecular & cellular mechanisms》2021,26(1):5-17
c-Jun N-terminal kinases (JNKs) are constitutively activated in mammalian brains and are indispensable for their development and neural functions. MKK7 is an upstream activator of all JNKs. However, whether the common JNK signaling pathway regulates the brain's control of social behavior remains unclear. Here, we show that female mice in which Mkk7 is deleted specifically in mature neurons (Mkk7flox/floxSyn-Cre mice) give birth to a normal number of pups but fail to raise them due to a defect in pup retrieval. To explore the mechanism underlying this abnormality, we performed comprehensive behavioral tests. Mkk7flox/floxSyn-Cre mice showed normal locomotor functions and cognitive ability but exhibited depression-like behavior. cDNA microarray analysis of mutant brain revealed an altered gene expression pattern. Quantitative RT-PCR analysis demonstrated that mRNA expression levels of genes related to neural signaling pathways and a calcium channel were significantly different from controls. In addition, loss of neural MKK7 had unexpected regulatory effects on gene expression patterns in oligodendrocytes. These findings indicate that MKK7 has an important role in regulating the gene expression patterns responsible for promoting normal social behavior and staving off depression. 相似文献
42.
Masashi Nakajima Takahiro Hiraoka Yoko Hirohara Tetsuro Oshika Toshifumi Mihashi 《Biomedical optics express》2015,6(7):2676-2694
Several researchers studied the longitudinal chromatic aberration (LCA) of the human eye and observed that it does not change due to age. We measured the LCA of 45 subjects’ normal right eyes at three distinct wavelengths (561, 690, and 840 nm) using a Hartmann–Shack wavefront aberrometer (HSWA) while consecutively switching between three light sources for wavefront sensing. We confirmed that the LCA of the human eye does not change due to age between 22 and 57 years.OCIS codes: (330.7325) Visual optics, metrology; (170.4460) Ophthalmic optics and devices; (330.5370) Physiological optics; (330.4875) Optics of physiological systems; (330.7326) Visual optics, modeling 相似文献
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In heart cells, several plasma membrane ion channels are targets for phosphorylation. However, it is not known whether sarcoplasmic reticulum (SR) ion channels, which are also essential in the regulation of cardiac function, are regulated by second-messenger systems. Here, we show that a Cl- channel in the cardiac SR membrane is activated by the catalytic subunit of protein kinase A (PKA). Purified cardiac heavy SR vesicles were incorporated into planar lipid bilayers. This channel spontaneously inactivated within a few minutes after the channel was incorporated into the bilayer. Mg-ATP (2-5 mM), but not the nonhydrolyzable ATP analogue 5'-adenylylimidodiphosphate, added to the cis solution prevented this spontaneous channel inactivation. After the inactivation process occurred, the catalytic subunit of PKA (with 0.05 mM Mg-ATP) reactivated this channel. These effects of Mg-ATP and PKA on the Cl- channel were prevented by an inhibitor of PKA. Thus, these results suggest that this SR Cl- channel is a novel target of PKA-dependent phosphorylation in cardiac muscle regulation. 相似文献
45.
Maeda S Iesaka Y Uno K Otomo K Nagata Y Suzuki K Hachiya H Goya M Takahashi A Fujiwara H Hiraoka M Isobe M 《Heart and vessels》2012,27(1):58-64
Few studies have explored the topographic anatomy of the esophagus, posterior wall of the left atrium (LA), or fat pads using multidetector computed tomography (MDCT) to prevent the risk of esophageal injury during atrial fibrillation (AF) ablation. MDCT was performed in 110 consecutive patients with paroxysmal or persistent AF before the ablation procedure to understand the anatomic relationship of the esophagus. Two major types of esophagus routes were demonstrated. Leftward (type A) and rightward (type B) routes were found in 90 and 10% of the patients, respectively. A type A route had a larger mean size of the LA than type B. The fat pad was identifiable at the level of the inferior pulmonary vein in 91% of the patients without any predominance of either type. The thickness of the fat pad was thinner in the patients with a dilated LA (>42?mm) than in those with a normal LA size (??42?mm) (p?=?0.01). The results demonstrated that the majority of cases had a leftward route of the esophagus. There was a close association between the LA dilatation and fat pad thinning. With a dilated LA, the esophagus may become easily susceptible to direct thermal injury during AF ablation. Visualization of the anatomic relationship may contribute to the prevention of the potential risk of an esophageal injury. 相似文献
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48.
A. Hiraoka H. Yoshitaka G. Chikazawa A. Ishida T. Totsugawa M. Kuinose 《European Journal of Vascular and Endovascular Surgery Extra》2012,23(5):e45-e47
IntroductionAlthough several articles have reported the successful treatment of an abdominal aortic aneurysm (AAA) enlargement after endovascular aortic repair (EVAR) due to endoleak or endotension, the strategy to treat this type of complication is still controversial.ReportWe report three cases of AAA expansion after EVAR. When other endovascular approaches were not considered effective, we performed a modified open surgical treatment.DiscussionThis technique includes ligation of all branched vessels arising from the aneurismal sac, plication of the aneurysm and wrapping of the aneurysm using bio-prosthetic material instead of explanting the implanted endovascular graft. 相似文献
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Takehiro Hiraoka Osamu Wada-Hiraike Yasushi Hirota Tetsuya Hirata Kaori Koga Yutaka Osuga Tomoyuki Fujii 《Reproductive Medicine and Biology》2016,15(2):121-126