全文获取类型
收费全文 | 9018篇 |
免费 | 376篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 162篇 |
妇产科学 | 136篇 |
基础医学 | 1189篇 |
口腔科学 | 159篇 |
临床医学 | 537篇 |
内科学 | 2552篇 |
皮肤病学 | 136篇 |
神经病学 | 645篇 |
特种医学 | 523篇 |
外科学 | 1397篇 |
综合类 | 24篇 |
预防医学 | 299篇 |
眼科学 | 148篇 |
药学 | 557篇 |
中国医学 | 16篇 |
肿瘤学 | 908篇 |
出版年
2023年 | 35篇 |
2022年 | 82篇 |
2021年 | 133篇 |
2020年 | 79篇 |
2019年 | 108篇 |
2018年 | 136篇 |
2017年 | 107篇 |
2016年 | 143篇 |
2015年 | 155篇 |
2014年 | 222篇 |
2013年 | 253篇 |
2012年 | 439篇 |
2011年 | 477篇 |
2010年 | 238篇 |
2009年 | 267篇 |
2008年 | 437篇 |
2007年 | 475篇 |
2006年 | 447篇 |
2005年 | 492篇 |
2004年 | 472篇 |
2003年 | 416篇 |
2002年 | 403篇 |
2001年 | 308篇 |
2000年 | 289篇 |
1999年 | 258篇 |
1998年 | 131篇 |
1997年 | 106篇 |
1996年 | 110篇 |
1995年 | 81篇 |
1994年 | 71篇 |
1993年 | 65篇 |
1992年 | 175篇 |
1991年 | 172篇 |
1990年 | 169篇 |
1989年 | 173篇 |
1988年 | 135篇 |
1987年 | 137篇 |
1986年 | 140篇 |
1985年 | 101篇 |
1984年 | 107篇 |
1983年 | 80篇 |
1982年 | 36篇 |
1981年 | 41篇 |
1980年 | 36篇 |
1979年 | 57篇 |
1978年 | 44篇 |
1977年 | 43篇 |
1974年 | 42篇 |
1972年 | 37篇 |
1970年 | 47篇 |
排序方式: 共有9447条查询结果,搜索用时 15 毫秒
31.
Yu Kojima Hisao Fujii Renta Katsui Yoshiyuki Nakajima Miyako Takaki 《Journal of Smooth Muscle Research》2006,42(5):139-147
The defecation reflex is composed of rectal distension-evoked rectal (R-R) reflex contractions and synchronous internal anal sphincter (R-IAS) reflex relaxations in guinea pigs. These R-R and R-IAS reflexes are controlled via extrinsic sacral excitatory nerve pathway (pelvic nerves), lumbar inhibitory nerve pathways (colonic nerves) and by intrinsic cholinergic excitatory and nitrergic inhibitory nerve pathways. The effect of mosapride (a prokinetic benzamide) on the intrinsic reflexes, mediated via enteric 5-HT(4) receptors, was evaluated by measuring the mechanical activity of the rectum and IAS in anesthetized guinea pigs using an intrinsic R-R and R-IAS reflex model resulting from chronic (two to nine days) lumbosacral denervation (PITH). In this model, the myenteric plexus remains undamaged and the distribution of myenteric and intramuscular interstitial cells of Cajal is unchanged. Although R-R and R-IAS reflex patterns markedly changed, the reflex indices (reflex pressure or force curve-time integral) of both the R-R contractions and the synchronous R-IAS relaxations were unchanged. The frequency of the spontaneous R and IAS motility was also unchanged. Mosapride (0.1-1.0 mg/kg) dose-dependently increased both intrinsic R-R (maximum: 1.82) and R-IAS reflex indices (maximum: 2.76) from that of the control (1.0) 6-9 days following chronic PITH. The dose-response curve was similar to that in the intact guinea pig, and had shifted to the left from that in the guinea pig after acute PITH. A specific 5-HT(4) receptor antagonist, GR 113808 (1.0 mg/kg), decreased both reflex indices by approximately 50% and antagonized the effect of mosapride 1.0 mg/kg. This was quite different from the result in the intact guinea pig where GR 113808 (1.0 mg/kg) did not affect either of the reflex indices. The present results indicate that mosapride enhanced the intrinsic R-R and R-IAS reflexes and functionally compensated for the deprivation of extrinsic innervation. The actions of mosapride were mediated through endogenously active, intrinsic 5-HT(4) receptors which may be post-synaptically located in the myenteric plexus of the anorectum. 相似文献
32.
Takashi Murakami Hitoshi Horigome Kiyoji Tanaka Yoshio Nakata Yasutomi Katayama Akira Matsui 《Blood coagulation & fibrinolysis》2007,18(5):389-394
Obesity is a risk factor for cardiovascular disease and thromboembolic events. We investigated the effects of weight reduction by a 12-week calorie-restricted diet with or without aerobic exercise (diet group and diet plus exercise group) on leptin and anticoagulation proteins levels. Forty-two obese nondiabetic individuals were evaluated for blood levels of leptin, protein C activity, free protein S antigen and for body fat area calculated on computerized tomography before and after intervention. Before intervention, serum levels of leptin and free protein S antigen correlated positively with several adiposity-related parameters. After the program, body weight and fat area were significantly decreased in both groups. Body mass index and leptin levels decreased in both groups, with a larger change in the diet plus exercise group than in the diet group. Although protein C activity levels did not change in both groups, free protein S antigen levels decreased significantly in the diet plus exercise group. In conclusion, the 12-week programs had significant effects on the initial weight reduction and body fat mass, decreasing lepin levels in obese nondiabetic individuals. To clarify whether aerobic exercise has additional or direct effects on the anticoagulation system, a study in a large number of individuals is needed. 相似文献
33.
Mitsuru Masaki Tadashi Kuroda Naoki Hosen Hisao Hirota Kazuo Terai Yuichi Oshima Yoshikazu Nakaoka Shoko Sugiyama Ryusuke Kimura Satoshi Yoshihara Manabu Kawakami Norishige Iizuka Yasuhiko Tomita Hiroyasu Ogawa Ichiro Kawase Keiko Yamauchi-Takihara 《Journal of the American Society of Echocardiography》2004,17(4):397-398
A 57-year-old man with a history of renal cell carcinoma presented with presyncope. He underwent nephrectomy years earlier followed by HLA-matched allogeneic peripheral-blood stem-cell transplantation. Echocardiographic investigation revealed a solitary right ventricle mass without contiguous vena caval or right atrial involvement. The mass was pathologically confirmed to be metastatic carcinoma in the right ventricular cavity. This case highlights the need to consider an underlying neoplastic syndrome in patients presenting isolated right ventricle mass by echocardiography. 相似文献
34.
Mié Matsui Hiromi Yuuki Kanade Kato Ai Takeuchi Shimako Nishiyama Warren B Bilker Masayoshi Kurachi 《Journal of the International Neuropsychological Society》2007,13(4):672-682
This study compares neuropsychological functioning in a Japanese schizophrenia spectrum disorder group and a group of healthy Japanese volunteers. Participants were 37 patients diagnosed with schizophrenia, 28 schizotypal patients, and 99 psychiatrically-normal volunteers. A wide range of cognitive measures were examined. All participants completed a Japanese version of a neuropsychological battery assessing executive function, working memory, processing speed, language, verbal memory, and spatial organization. Comparisons of neuropsychological function demonstrated similarities and differences between patients diagnosed with schizotypal disorder and those diagnosed with schizophrenia. Impairments in verbal memory, language, and processing speed were common to both patient groups and may represent a vulnerability to schizophrenia. Impairments in aspects of working memory, spatial organization and executive function were preferentially observed in schizophrenia and may be features of the overt manifestation of psychosis. Possible differences in the contributions of prefrontal and temporo-limbic structures provide direction for further studies. 相似文献
35.
Hodaka Fukazawa Hidehiko Kawabata Yoshito Matsui 《Journal of children's orthopaedics》2009,3(4):277-282
Purpose To describe three cases of mirror foot and to develop a new classification of the mirror feet with an emphasis on their treatment.
Methods Surgical treatment was performed on three patients with mirror foot. Mirror feet in the English literature were surveyed and
cases found in PubMed as well as our three cases were classified according to a new classification that was an analogy of
the mirror hand classification proposed by Al-Qattan et al. (J Hand Surg Br 23:534–536, 1998).
Results All three cases obtained satisfactory outcome after the treatment. In addition to these cases, 28 mirror feet were well described
in the English literature, among which only seven cases have been documented for their treatment. All of the cases could be
assigned to one of the categories of the proposed classification.
Conclusion Mirror foot is a very rare congenital deformity of the foot. We successfully treated three novel cases of mirror feet. A classification
of the mirror feet proposed in this article was useful in order to understand its nature and obtain a guideline for its treatment. 相似文献
36.
H Matsui 《The Japanese journal of physiology》1992,42(5):831-834
The influence of a high ambient temperature on sympathetic neurotransmitter release in bullfrogs was studied. Gastrointestinal vascular perfusates were collected before and after splanchnic nerve stimulation, and their content of epinephrine and norepinephrine was determined. A marked increase in epinephrine and norepinephrine release was observed following stimulation at 29-32 degrees C, indicating that epinephrine and norepinephrine may both act as adrenergic transmitters in a high-temperature environment. 相似文献
37.
Cefuzonam (CZON, L-105) was studied clinically in the field of obstetrics and gynecology, and the results obtained are summarized below: 1. The concentration of the drug in blood decreased rapidly after drip infusion was completed, and the concentration diminished after 1 hour to one tenth of the level detected at 5-9 minutes, and to an almost undetectable level after 3 hours. The rapid decrease of blood concentrations appears to indicate that the excretion of CZON was much faster than other antibiotics. No conclusive data were obtained on changes of concentrations with time in tissues due to the small number of cases analyzed and scattering of the data obtained. 2. The concentration in the pelvic dead space exudate reached a peak of 18.5 micrograms/ml at 30 minutes after the end of infusion and decreased to 0.092 microgram/ml after 10 hours. 3. CZON was administered to 5 cases of obstetric and gynecological infections. The efficacy was good in 4 cases and poor in 1 case. No side effects or laboratory test abnormalities were observed. 相似文献
38.
39.
Masahiro Tsuboi Hisao Asamura Tsuguo Naruke Haruhiko Nakayama Haruhiko Kondo Ryosuke Tsuchiya 《Surgery today》1997,27(11):1074-1076
A video-assisted right upper lobectomy was successfully performed on a 58-year-old man with an anomalnous segmental pulmonary
vein. The tumor was a peripherally located adenocarcinoma. The anomalous vein behind the right main bronchus was identified
and safely divided. This case emphasized that to perform this procedure successfully, (1) a careful preoperative evaluation
of the anatomy, including the presence of any possible vascular and/or bronchial anomalies, is necessary, and (2) if any anatomical
structures cannot be determined intraoperatively, a conversion into an open procedure must immediately be undertaken. 相似文献
40.