全文获取类型
收费全文 | 89篇 |
免费 | 2篇 |
国内免费 | 1篇 |
专业分类
基础医学 | 6篇 |
临床医学 | 5篇 |
内科学 | 23篇 |
皮肤病学 | 1篇 |
神经病学 | 7篇 |
特种医学 | 4篇 |
外科学 | 16篇 |
预防医学 | 5篇 |
药学 | 10篇 |
肿瘤学 | 15篇 |
出版年
2021年 | 4篇 |
2019年 | 6篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2013年 | 5篇 |
2012年 | 3篇 |
2011年 | 4篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 2篇 |
2007年 | 1篇 |
2006年 | 8篇 |
2005年 | 7篇 |
2004年 | 7篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 5篇 |
1993年 | 1篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 2篇 |
排序方式: 共有92条查询结果,搜索用时 15 毫秒
61.
Yusuke Takizawa Hisanao Kishimoto Minami Nakagawa Nasa Sakamoto Yoshifusa Tobe Takahito Furuya Mikio Tomita Masahiro Hayashi 《International journal of pharmaceutics》2013
Pharmaceutical excipients should not disturb the effects of drug therapy. In recent years, however, it has been reported that excipients induce some changes to the tight junction (TJ) and P-glycoprotein (P-gp), which can affect drug disposition. In this study, we examined the effects of 20 common pharmaceutical excipients from different classes on mucosal membrane and the differences of such effects among regions of the small intestine. We used the in vitro sac method in rat jejunum and ileum to study the effects of excipients on the membrane permeation of 5(6)-carboxyfluorescein (5-CF). 5-CF was used as a model of water-soluble compounds. In some dosage conditions of methyl-β-cyclodextrin, the membrane permeability of 5-CF was significantly increased in the jejunum, but such change was not observed in the ileum. Similarly, in the cases of sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose and croscarmellose sodium, the membrane permeability of 5-CF was significantly increased in the jejunum, but no change was observed in the ileum. On the other hand, in both the jejunum and the ileum, the membrane permeation of 5-CF was decreased with 0.02% (w/v) hydroxypropyl cellulose, but significantly increased with it at 0.20% (w/v). It was shown that excipients affected the membrane permeability of water-soluble compounds via the paracellular route, and these effects on absorption differed among regions of the small intestine. Moreover, in the case of 20 excipients, not only an increase in membrane permeability but also a decrease was observed. Therefore, it was suggested that a more effective formulation could be designed by changing the combination of excipients. 相似文献
62.
63.
Murakami M Tsuchiya K Ichikawa H Kawaguchi K Sugiyama A Ishida K Chisuwa H Kawasaki S 《Journal of gastroenterology》2000,35(9):702-711
We report a rare case of esophageal intramural pseudodiverticulosis with lower esophageal stricture which perforated into
the peritoneal cavity after the patient vomited. A 61-year-old man was admitted with severe chest and epigastric pain after
dysphagia and vomiting. Under a diagnosis of upper gastrointestinal perforation, laparotomy was performed. The anterior wall
of the abdominal esophagus was found to have ruptured, and proximal gastrectomy with abdominal esophagectomy was performed.
His-tological examination revealed esophageal intramural pseudodiverticulosis with esophageal stricture distal to the site
of rupture, and postoperative endoscopy showed diffuse pseudodiverticulosis in the remaining esophagus. The patient is free
of symptoms 5 years after the surgery. This case suggests that careful treatment may be indicated in patients with esophageal
intramural pseudodiverticulosis with stricture and elevated intraluminal pressure, to minimize the possibility of severe complications
such as esophageal perforation.
Received: June 7, 1999 / Accepted: January 28, 2000 相似文献
64.
65.
Kenji Isahaya Tamihiro Kawakami Makoto Shiraishi Hisanao Akiyama Yasuhiro Hasegawa 《The Journal of dermatology》2017,44(11):1299-1302
Some patients originally diagnosed with cutaneous arteritis (CA) could develop additional disease manifestations, including peripheral neurological involvement. We evaluated the biological neurological parameters among CA patients who underwent nerve conduction studies for neurological involvement in the lower extremities. We reviewed 164 patients who were originally diagnosed with CA at our dermatology department between 2004 and 2015. Seventeen (10.4%) of the CA patients underwent further nerve conduction studies to determine their peripheral neurological manifestations, primarily in the lower extremities, in our neurology division. The frequency of low compound muscle action potential (CMAP) was significantly higher compared with that of delayed latency in both the peroneal nerve and sural nerve based on nerve conduction studies. The frequency of low CMAP was significantly higher compared with that of prolonged distal latency in both the peroneal and sural nerves. We suggest that impairment of the nerve axon pathways in the peroneal and sural nerves could result in the peripheral neurological manifestations in the lower extremities in CA patients. 相似文献
66.
Norii Tatsuya Makino Yohsuke Unuma Kana Adolphi Natalie L. Albright Danielle Sklar David P. Crandall Cameron Braude Darren 《Emergency radiology》2021,28(3):665-673
Emergency Radiology - Compared to intubation with a cuffed endotracheal tube, extraglottic airway devices (EGDs), such as laryngeal mask airways, are considered less definitive ventilation conduit... 相似文献
67.
Awareness of atrial fibrillation in Japan: A large‐scale,nationwide Internet survey of 50 000 Japanese adults 下载免费PDF全文
Aim
Atrial fibrillation (AF) is the most common underlying cause of cardiogenic cerebral embolism. To prevent cardiogenic cerebral embolism, it is important to determine the level of awareness of AF in Japan.Methods
We used survey monitor attribute data to sample 172 824 Japanese adults aged ≥50 years from all 47 Japanese prefectures. Next, we carried out an Internet survey to determine these individuals’ level of awareness of AF.Results
We obtained valid responses from 53 128 respondents. There were 13 119 respondents (27.5%) spanning all age groups who had never heard the term AF (no prior knowledge), just 1791 respondents (3.8%) who knew AF well and 27 351 respondents (57.3%) who knew the name of the condition, but did not understand the disease or its treatment. No prior knowledge was highest in Kochi Prefecture (36.0%) and lowest in Yamanashi Prefecture. Knowing AF well was highest in Kyoto Prefecture (5.1%) and lowest in Tottori Prefecture, and knowing only the name was highest in Aomori Prefecture (63.0%). Factors contributing significantly to having “no prior knowledge” of AF included younger age, male sex and smaller population size (rural region), but not the numbers of arrhythmia or stroke specialists.Conclusions
Currently, 3.8% of Japanese adults had high awareness of AF, and we find this value very low. We also noted age‐, sex‐ and region‐related differences in awareness level. We believe that awareness initiatives that take into account age‐ and sex‐related differences and prioritize prefectures with lower awareness of AF will be important for preventing cardiogenic cerebral embolism in the future. Geriatr Gerontol Int 2018; 18: 1100–1107 . 相似文献68.
Kokichi Sugano Hisanao Ohkura Setsuo Hirohashi Yukio Shimosato Yoichi Sakurai Susumu Kodaira Osahiko Abe 《Cancer science》1989,80(12):1156-1160
The levels and character of carcinoembryonic antigen (CEA) in feces were investigated by sandwich radioimmunometric assay using anti-CEA monoclonal antibodies NCC-CO-411 and NCC-CO-432. Mean CEA concentration was significantly higher ( P < 0.001) in the feces from patients with colorectal carcinoma and other gastrointestinal disorders as compared to normal adults. More than 90% of the fecal CEA was trapped by a 0.22 μ m membrane filter and solubilized by treatment with 1% Triton X-100 or phosphatidyl-inositol specific phospholipase C. In hydrophobic chromatography, most of the fecal CEA was eluted at the lowest (NH4 )2 SO4 concentration while serum CEA appeared in the more hydrophilic fractions. These results suggest that the majority of CEA exists in feces as an amphiphilic molecule or a membrane-bound form. The increase of fecal CEA may reflect the destruction and abrasion of epithelial cells in various gastrointestinal disorders. 相似文献
69.
Yuji Matsuoka Yoshino Matsuo Kokichi Sugano Hisanao Ohkura Motomu Kuroki Masahide Kuroki 《Cancer science》1990,81(5):514-519
About 50–70 mg in total of carcinoembryonic antigen (CEA) (or CEA-related antigens) was detected in normal adult feces evacuated during one day (200–250 g). Ten percent or less of the antigen was found to be in soluble form in fresh feces (naturally solubilized antigen), while 90% or more was still in membrane-bound form which was releasable with phosphatidylinositol-specific phospholipase C (PI-PLC-solubilized antigen). The naturally solubilized and PI-PLC-solubilized antigens are anti-genically different from each other and similar to normal fecal antigen (NFA)-2 and CEA, respectively, suggesting that "CEA-distinctive'antigenicity detected so far in CEA from cancerous tissues is not due to the difference between antigens in normal and malignant tissues but is probably due to the presence of the glycosylinositolphosphate moiety at the carboxyl-terminus of the antigen molecule. Thus, "CEA-distinctive'antigenicity is by no means cancer-specific, but this antigenicity seems to be critical for the clinical significance of CEA as a tumor marker, because an assay system (Kit II) which is able to distinguish CEA from NFA-2 revealed much improved features in cancer diagnosis as reported recently. 相似文献
70.
Aminophilline suppress the release of chemical mediators in treatment of acute asthma 总被引:2,自引:0,他引:2
Nakano J Yano T Yamamura K Yoshihara H Ohbayashi O Yamashita N Ohta K 《Respiratory medicine》2006,100(3):542-550
BACKGROUND: The control of airway inflammation is crucial for management of asthma. Theophylline has been demonstrated to have an anti-inflammatory effect as a long-term-medication for asthma in various studies. In the present study we attempted to clarify if aminophylline, a theophylline derivative, could act as an anti-inflammatory agent as well as a bronchodilator in the treatment for acute asthma exacerbations. METHODS: Patients are initially treated either with an intravenous infusion of aminophylline or with inhalation of salbutamol. Pro-inflammatory mediators such as eosinophil cationic protein (ECP), histamine, serotonin, thromboxane B2, leukotriene C4 were measured before and one hour after the initial treatment. Clinical parameters such as peak expiratory flow (PEF) and SpO2 were also checked during the studies. RESULTS: Significant improvements of PEF and SpO2 with both aminophylline and salbutamol treatment were seen. Furthermore, significant decreases of ECP, histamine, and serotonin were observed with aminophylline but not with salbutamol. CONCLUSIONS: Suppressing the release of pro-inflammatory mediators may play a role, at least in part, in the beneficial effects of aminophylline in the treatment of acute exacerbations in asthma. Additionally, this study indicated that treatment with aminophylline is at least as beneficial as nebulized salbutamol in the restoration of lung function. 相似文献