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101.
Grooved pegboard test as a biomarker of nigrostriatal denervation in Parkinson's disease 总被引:1,自引:0,他引:1
Recent pharmacotherapy trials in Parkinson's disease (PD) using dopaminergic neuroimaging as outcome parameter failed to show significant relationships between imaging and clinical results. One possible explanation is that there is a non-linear relationship between striatal denervation and motor performance reflecting a statistical "floor" effect in the imaging data with advanced disease. Both the motor manifestations and the striatal dopamine denervation of idiopathic PD, however, are typically asymmetric and more meaningful associations may be found by comparing data from the least denervated striatum with motor performance in the corresponding body side. PD patients (n=28) underwent [11C]beta-CFT dopamine transporter (DAT) positron emission tomography (PET) and grooved pegboard testing. Voxel-based analysis of DAT PET and bimanual pegboard scores demonstrated significant correlation clusters within the bilateral striata (P<0.001). However, findings were most prominent in the least denervated striatum. There was a significant inverse correlation between pegboard scores of the least affected arm and DAT binding of the least denervated striatum (Rs=-0.69, P<0.0001) but no significant correlation between pegboard scores of the clinically most affected arm and DAT binding of the most denervated striatum (Rs=-0.15, ns). These data indicate that the robustness of the grooved pegboard test as a biomarker for nigrostriatal denervation in PD mainly reflects the relationship between test performance of the clinically least affected limb and the least denervated striatum. These findings indicate that there is both a statistical "floor" and "ceiling" effect for the most affected striatal and body sides that must be considered when employing imaging as an outcome measure in clinical trials in PD. 相似文献
102.
Kimura Yuta Tsunedomi Ryouichi Yoshimura Kiyoshi Matsukuma Satoshi Shindo Yoshitaro Matsui Hiroto Tokumitsu Yukio Yoshida Shin Iida Michihisa Suzuki Nobuaki Takeda Shigeru Ioka Tatsuya Hazama Shoichi Nagano Hiroaki 《Annals of surgical oncology》2022,29(12):7423-7433
Annals of Surgical Oncology - Poor prognosis in liver cancer is due to its high frequency of intrahepatic metastasis. Cancer stem-like cells (CSLCs), which possess the properties of stemness, tumor... 相似文献
103.
Yamashita Takehiro Terasaki Hiroto Tanaka Minoru Nakao Kumiko Sakamoto Taiji 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(8):1779-1785
Graefe's Archive for Clinical and Experimental Ophthalmology - To determine the relationship between the peripapillary choroidal thickness (ppCT) and the degree and distribution of the... 相似文献
104.
Deepali Kumar Oriol Manuel Yoichiro Natori Hiroto Egawa Paolo Grossi Sang‐Hoon Han Mario Fernndez‐Ruiz Atul Humar 《American journal of transplantation》2020,20(7):1773-1779
The COVID‐19 pandemic has rapidly evolved and changed our way of life in an unprecedented manner. The emergence of COVID‐19 has impacted transplantation worldwide. The impact has not been just restricted to issues pertaining to donors or recipients, but also health‐care resource utilization as the intensity of cases in certain jurisdictions exceeds available capacity. Here we provide a personal viewpoint representing different jurisdictions from around the world in order to outline the impact of the current COVID‐19 pandemic on organ transplantation. Based on our collective experience, we discuss mitigation strategies such as donor screening, resource planning, and a staged approach to transplant volume considerations as local resource issues demand. We also discuss issues related to transplant‐related research during the pandemic, the role of transplant infectious diseases, and the influence of transplant societies for education and disseminating current information. 相似文献
105.
Yojiro Koda Hiroto Kitahara Sara Kalantari Bow Chung Bryan Smith Jayant Raikhelkar Gene Kim Nitasha Sarswat Gabriel Sayer David Onsager Tae Song Nir Uriel Valluvan Jeevanandam Takeyoshi Ota 《Artificial organs》2020,44(4):367-374
The purpose of this study is to compare clinical outcomes of left ventricular assist device (LVAD) patients with device thrombosis who underwent device exchange (DE) or medical therapy (MT) alone. Consecutive patients undergoing LVAD implant between July 2008 and December 2017 were included. Device thrombosis was diagnosed with comprehensive assessments including ramp test, laboratory data, device parameters, and clinical presentations. First, MT was initiated in all patients. After MT, DE was considered if device thrombosis was refractory to initial MT, and it caused end-organ impairment and/or hemodynamic instability. Among 319 consecutive LVAD patients, 43 patients (13.5%) were diagnosed with device thrombosis. DE was performed in 28 patients (DE group); device explant was performed in 1 patient. MT was continued in 14 patients (MT group). In-hospital mortality was significantly lower in the DE group than the MT group (3.6% [1/28] vs. 28.6% [4/14], P = .0184). One-year survival was significantly better in the DE group (74.0% vs. 30.1%; log-rank = .001), and freedom from cerebrovascular accident (CVA) at 1 year was greater in the DE group (87.1% vs. 47.7%; log-rank = .004). DE was associated with improved 1-year survival and fewer CVAs. Surgical intervention, if feasible, is recommended for LVAD device thrombosis. 相似文献
106.
Noma Saki Yamashita Takehiro Asaoka Ryo Terasaki Hiroto Yoshihara Naoya Kakiuchi Naoko Sakamoto Taiji 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(12):2781-2789
Graefe's Archive for Clinical and Experimental Ophthalmology - Recently, artificial intelligence has been used to determine sex using fundus photographs alone. We had earlier reported that sex... 相似文献
107.
108.
Hiroto Kayashima Ken Shirabe Rumi Matono Shohei Yoshiya Kazutoyo Morita Kenji Umeda Toru Ikegami Tomoharu Yoshizumi Yuji Soejima Yoshihiko Maehara 《Surgery today》2014,44(11):2077-2085
Purpose
To evaluate the anatomical variations in the middle hepatic vein tributaries (V5/V8) for determining the reconstruction strategy in right lobe living donor liver transplantation (LDLT).Methods
The V5/V8 variations were examined in 268 patients and were classified into three and two types, respectively. The reconstruction rate (RR), patency rate (PR) and clinical outcomes were retrospectively evaluated in 46 right lobe LDLT cases.Results
In terms of V5 variations, the RR and PR were significantly higher for type 2 than type 3 (82.6 vs. 44.4 % and 73.7 vs. 25.0 %, respectively). The alanine aminotransferase level on postoperative day (POD) 5 in the V5 patent group was significantly lower than in the occluded group (123 vs. 191 IU/dL). Regarding V8 variations, the RR and PR were significantly higher for type 1 than type 2 (44.4 vs. 17.6 % and 75.0 vs. 33.3 %, respectively). The aspartate aminotransferase level on POD 3 was significantly lower in the V8 patent group than in the occluded group (50 vs. 121 IU/dL).Conclusion
For right lobe grafts with single large V5 (type 2) or V8 (type 1) variations, reconstruction is necessary. Our new classification of the MHV tributaries is useful for determining the reconstruction strategy to use in right lobe LDLT. 相似文献109.
Conversion of Aβ43 to Aβ40 by the successive action of angiotensin‐converting enzyme 2 and angiotensin‐converting enzyme
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Shuyu Liu Junjun Liu Yukie Miura Chiaki Tanabe Tomoji Maeda Yasuo Terayama Anthony J. Turner Kun Zou Hiroto Komano 《Journal of neuroscience research》2014,92(9):1178-1186
The longer and neurotoxic species of amyloid‐β protein (Aβ), Aβ42 and Aβ43, contribute to Aβ accumulation in Alzheimer's disease (AD) pathogenesis and are considered to be the primary cause of the disease. In contrast, the predominant secreted form of Aβ, Aβ40, inhibits amyloid deposition and may have neuroprotective effects. We have reported that angiotensin‐converting enzyme (ACE) converts Aβ42 to Aβ40 and that Aβ43 is the earliest‐depositing Aβ species in the amyloid precursor protein transgenic mouse brain. Here we found that Aβ43 can be converted to Aβ42 and to Aβ40 in mouse brain lysate. We further identified the brain Aβ43‐to‐Aβ42‐converting enzyme as ACE2. The purified human ACE2 converted Aβ43 to Aβ42, and this activity was inhibited by a specific ACE2 inhibitor, DX600. Notably, the combination of ACE2 and ACE could convert Aβ43 to Aβ40. Our results indicate that the longer, neurotoxic forms of Aβ can be converted to the shorter, less toxic or neuroprotective forms of Aβ by ACE2 and ACE. Moreover, we found that ACE2 activity showed a tendency to decrease in the serum of AD patients compared with normal controls, suggesting an association between lower ACE2 activity and AD. Thus, maintaining brain ACE2 and ACE activities may be important for preventing brain amyloid neurotoxicity and deposition in Alzheimer's disease. © 2014 Wiley Periodicals, Inc. 相似文献
110.
Chie Kitahara Shuhei Morita Shohei Kishimoto Shohei Matsuno Shinsuke Uraki Ken Takeshima Yasushi Furukawa Hidefumi Inaba Hiroshi Iwakura Hiroyuki Ariyasu Hiroto Furuta Masahiro Nishi Takashi Akamizu 《Journal of diabetes investigation.》2021,12(4):664-667
We report the first case of intraoperatively detected euglycemic diabetic ketoacidosis (DKA) associated with sodium–glucose cotransporter 2 inhibitors during thoracic surgery. A 59-year-old man had a 12-year history of type 2 diabetes mellitus treated with insulin and empagliflozin. The patient developed bacterial empyema and was initiated with antibiotics at a local hospital. Owing to the persistence of his symptoms, he was transferred to our hospital after the medication of empagliflozin the day before surgery. After overnight fasting, the patient underwent thoracoscopic debridement and intrathoracic lavage surgery. During this surgery, he was noted to have euglycemic ketosis and acidosis, and diagnosed as euglycemic DKA. Immediately after the consultation in our department, the patient underwent treatment for DKA. He awoke from anesthesia normally and showed no symptoms of DKA. DKA gradually resolved over the next 24 h. Early identification and management are critical for rapid recovery from perioperative euglycemic DKA associated with sodium–glucose cotransporter 2 inhibitors, especially during thoracic surgery. 相似文献