全文获取类型
收费全文 | 50124篇 |
免费 | 2314篇 |
国内免费 | 414篇 |
专业分类
耳鼻咽喉 | 486篇 |
儿科学 | 1132篇 |
妇产科学 | 563篇 |
基础医学 | 6465篇 |
口腔科学 | 923篇 |
临床医学 | 2936篇 |
内科学 | 12716篇 |
皮肤病学 | 1154篇 |
神经病学 | 3751篇 |
特种医学 | 2124篇 |
外科学 | 8943篇 |
综合类 | 187篇 |
一般理论 | 6篇 |
预防医学 | 1335篇 |
眼科学 | 1177篇 |
药学 | 3124篇 |
中国医学 | 177篇 |
肿瘤学 | 5653篇 |
出版年
2023年 | 276篇 |
2022年 | 560篇 |
2021年 | 981篇 |
2020年 | 514篇 |
2019年 | 719篇 |
2018年 | 982篇 |
2017年 | 746篇 |
2016年 | 966篇 |
2015年 | 1061篇 |
2014年 | 1360篇 |
2013年 | 1728篇 |
2012年 | 2801篇 |
2011年 | 3093篇 |
2010年 | 1771篇 |
2009年 | 1635篇 |
2008年 | 2929篇 |
2007年 | 3200篇 |
2006年 | 3196篇 |
2005年 | 3203篇 |
2004年 | 3311篇 |
2003年 | 3364篇 |
2002年 | 3290篇 |
2001年 | 770篇 |
2000年 | 703篇 |
1999年 | 762篇 |
1998年 | 857篇 |
1997年 | 716篇 |
1996年 | 674篇 |
1995年 | 558篇 |
1994年 | 515篇 |
1993年 | 556篇 |
1992年 | 497篇 |
1991年 | 458篇 |
1990年 | 406篇 |
1989年 | 409篇 |
1988年 | 363篇 |
1987年 | 305篇 |
1986年 | 269篇 |
1985年 | 279篇 |
1984年 | 232篇 |
1983年 | 198篇 |
1982年 | 148篇 |
1981年 | 168篇 |
1980年 | 148篇 |
1979年 | 129篇 |
1978年 | 133篇 |
1977年 | 116篇 |
1976年 | 88篇 |
1975年 | 77篇 |
1972年 | 72篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Atsushi Yoshimura Mitsuru Kimura Sachio Matsushita Jun-ichi Yoneda Hitoshi Maesato Yasunobu Komoto Hideki Nakayama Hiroshi Sakuma Yosuke Yumoto Tsuyoshi Takimura Tomomi Tohyama Chie Iwahara Takeshi Mizukami Akira Yokoyama Susumu Higuchi 《Alcoholism, clinical and experimental research》2021,45(11):2335-2346
992.
Kenta Suzuki Kiyokazu Akasaka Takahiro Otsudo Yutaka Sawada Hiroshi Hattori Yuki Hasebe Yasuaki Mizoguchi Toby M. Hall Mitsuru Yamamoto 《Medicine》2021,100(14)
Background:In recent years, the functional movement screen (FMS) and FMS training have attracted attention as a means of preventing injury, but no studies have examined the effect of such training in high-school baseball players. The aim of this study was to clarify the effect of FMS training on FMS score, physical function and baseball performance in high-school baseball players.Methods:Subjects in this randomized controlled clinical trial were high-school male baseball players assigned to either an FMS training group (intervention group) or a control group. The intervention group performed FMS training 4 times per week for 12 weeks. FMS ability, physical function, and baseball performance were measured prior to the intervention, 8, 12, and 24 weeks after the intervention in the subjects’ school environment.Results:A total of 71 baseball players aged 15 to 17 years were recruited and assigned to either an intervention group (n = 37) or control group (n = 34). There was no significant difference in the characteristics of participants between the 2 groups. Most FMS scores improved to 12 weeks after continued training. In the intervention group compared with the control group, deep squat, hurdle step, inline lunge, active straight leg raise, trunk stability push-up and rotary stability FMS score, total FMS score and eyes closed single leg stance time significantly increased after 8 weeks of training. While hurdle step, inline lunge, active straight leg raise, trunk stability push-up, total FMS score, and eyes closed single leg stance time significantly increased, pitching ball speed significantly decreased at the end of the 12 week training period. Eyes closed single leg stance time and feeling of fatigue significantly improved 12 weeks after training. The number of subjects who scored less than 14 for the total FMS score in the intervention group compared with control group were significantly less after 8 and 12 weeks of FMS training.Conclusion:FMS training for 8 weeks contributes to improving FMS scores for high-school baseball players, but FMS scores go down if FMS training is not continued.Trial registration:University Hospital Medical Information Network Center, Tokyo, Japan: UMIN000027553. Registered on May 30, 2017. 相似文献
993.
Kihara Mari Sugihara Takahiko Asano Junichi Sato Midori Kaneko Hiroshi Muraoka Sei Ohshima Shiro Nanki Toshihiro 《Clinical rheumatology》2022,41(12):3661-3673
Clinical Rheumatology - To describe clinical characteristics of patients in Japan with coronavirus disease 19 (COVID-19) and pre-existing rheumatic disease and examine the possible risk factors... 相似文献
994.
Yamashita Yugo Amano Hidewo Morimoto Takeshi Kadota Kazushige Hata Reo Matsushita Kazuki Osakada Kohei Sano Arata Takase Toru Hiramori Seiichi Kim Kitae Oi Maki Akao Masaharu Kobayashi Yohei Toyofuku Mamoru Inoko Moriaki Tada Tomohisa Chen Po-Min Murata Koichiro Tsuyuki Yoshiaki Nishimoto Yuji Sasa Tomoki Sakamoto Jiro Kinoshita Minako Togi Kiyonori Mabuchi Hiroshi Takabayashi Kensuke Kato Takao Ono Koh Kimura Takeshi 《Journal of thrombosis and thrombolysis》2022,53(1):182-190
Journal of Thrombosis and Thrombolysis - Prolonged anticoagulation therapy is recommended for patients with intermediate-risk for recurrence of venous thromboembolism (VTE). The current study aimed... 相似文献
995.
Yoshikazu Uchiyama Akiko Abe Chisako Muramatsu Takeshi Hara Junji Shiraishi Hiroshi Fujita 《Journal of digital imaging》2015,28(1):116-122
Detection of lacunar infarcts is important because their presence indicates an increased risk of severe cerebral infarction. However, accurate identification is often hindered by the difficulty in distinguishing between lacunar infarcts and enlarged Virchow-Robin spaces. Therefore, we developed a computer-aided detection (CAD) scheme for the detection of lacunar infarcts. Although our previous CAD method indicated a sensitivity of 96.8 % with 0.71 false positives (FPs) per slice, further reduction of FPs remained an issue for the clinical application. Thus, the purpose of this study is to improve our CAD scheme by using template matching in the eigenspace. Conventional template matching is useful for the reduction of FPs, but it has the following two pitfalls: (1) It needs to maintain a large number of templates to improve the detection performance, and (2) calculation of the cross-correlation coefficient with these templates is time consuming. To solve these problems, we used template matching in the lower dimension space made by a principal component analysis. Our database comprised 1,143 T1- and T2-weighted images obtained from 132 patients. The proposed method was evaluated by using twofold cross-validation. By using this method, 34.1 % of FPs was eliminated compared with our previous method. The final performance indicated that the sensitivity of the detection of lacunar infarcts was 96.8 % with 0.47 FPs per slice. Therefore, the modified CAD scheme could improve FP rate without a significant reduction in the true positive rate. 相似文献
996.
Kazunori Gomi Makoto Miki Shigeru Itabashi Tohru Kikuchi Shinichi Miur Toshiki Shikanai Hiroshi Inoue Kenichi Takeuchi Akio Kanda Shuzo Suzukio Hideyuki Nakagawa Mitsunobu Hommma Hiroshi Miki Tatsuya Abe Katsushi Nishimaki Hiroshi Saito Hideo Yasugahir Tsuneo Sayam Makoto Sat Ryo Kikuchi Yoshihiro Honda Akihiko Kawan Akira Watanabe 《Nihon Kokyūki Gakkai zasshi》2007,45(11):836-843
We evaluated the usefulness of domestic and foreign guidelines for the diagnosis and treatment of patients with community-acquired-pneumonia at 23 institutions in 6 prefectures of the Tohoku Area, from December 2003 to November 2004. Based on the old and new Japanese Respiratory Society (JRS) guidelines, we evaluated severity, clinical efficacy and detection of atypical pneumonia. As for severity, the old guidelines led to the diagnosis of an excessive number of 'severe' cases. On the other hand, patients were appropriately diagnosed as having mild, moderate, severe, or very severe disease based on the new JRS guidelines (2005). The severity classification often correlated with the Pneumonia Severity Index (PSI) of the IDSA guidelines. The efficacy rate for patients who were prescribed the recommended drug according to the old JRS guidelines was 85.7% and for those who did not use the recommended drug it was 68.7% (p < 0.001). 相似文献
997.
Kensaku Yamaga Eisuke Kobayashi Daisuke Kubota Nokitaka Setsu Yuya Tanaka Yusuke Minami Yoshikazu Tanzawa Fumihiko Nakatani Akira Kawai Hirokazu Chuman 《Pediatrics international》2015,57(5):996-999
Myositis ossificans (MO) is a rare benign cause of heterotopic bone formation in soft tissue that most commonly affects young adults, typically following trauma. We report the case of an 11‐year‐old girl who developed MO mimicking osteosarcoma in her right shoulder. Plain radiography and computed tomography showed poorly defined flocculated densities in the soft tissue and a periosteal reaction along the proximal humerus. On magnetic resonance imaging, the mass displayed an ill‐defined margin and inhomogeneous signal change. Histologically, the mass had a pseudosarcomatous appearance. Based on these findings, the patient was initially misdiagnosed with osteosarcoma at another hospital. The diagnosis was difficult because the patient was 11 years old and had no trauma history, with atypical radiographic changes and a predilection for the site of origin for osteosarcomas. We finally made the correct diagnosis of MO by carefully reviewing and reflecting on the pathological differences between stages. 相似文献
998.
Helicobacter pylori infection has been found to decrease the expression of antral somatostatin and to increase the release of the acid-stimulating
hormone gastrin. The reversal of these changes in gut hormones by the eradication of H. pylori, and in-vivo and in-vitro studies in animals either infected with H. pylori or exposed to H. pylori-related materials may support the somatostatin-gastrin link theory in the pathophysiology of H. pylori infection. The following mechanisms have been proposed to explain the H. pylori infection-associated changes in gut hormones; (1) ammonia produced by H. pylori and monochloramine, (2) effect on somatostatin receptor subtype-2, (3) action of lipopolysaccharide from H. pylori on somatostatin receptor, (4) inflammatory cells and mediators, and (5) bacterial strain diversity. H. pylori infection can alter gastric acid secretion in both directions. The elevated acid secretion in patients with duodenal ulcer
is decreased by H. pylori eradication, and is accompanied by the normalization of gut hormones in patients whose H. pylori-induced gastritis is limited to the antrum with hyperacidity. Corpus gastritis and the subsequent development of mucosal
atrophy induced by H. pylori result in decreased acid secretion, although the mechanism underlying H. pylori-induced atrophy in some subjects remains unclear. Hypoacidity enhances corpus atrophy and increases gastrin secretion, mediated
via a physiological suppression of somatostatin release, features that are also observed in H. pylori infection. Therefore, the capacity of acid secretion and distribution of gastritis or atrophy should be taken into consideration
when we discuss the affect of H. pylori on gut hormones.
Received: October 1, 2001 / Accepted: November 30, 2001 相似文献
999.
Hiroshi Tada Minoru Yamada Shigeto Naito Akihiko Nogami Shigeru Oshima Koichi Taniguchi 《Journal of interventional cardiac electrophysiology》2006,15(1):35-41
We describe a patient who underwent radiofrequency (RF) catheter ablation of symptomatic atrial fibrillation. After left atrial
(LA) catheter ablation and pulmonary vein isolation, a macro-reentrant atrial tachycardia (AT) with a critical isthmus at
the mitral isthmus was induced by incremental atrial pacing from the coronary sinus. Extensive RF energy applications from
endocardial sites using ablation catheters with 4 mm- and 8 mm- tips resulted in no discrete potentials being recorded from
the endocardial sites of the isthmus, but the tachycardia could not be terminated. However, discrete potentials were recorded
within the CS, and epicardial RF energy applications from the CS eliminated the tachycardia. Thus, mapping in the CS is useful
for detecting residual conduction at epicardial sites along the mitral isthmus. RF catheter ablation within the CS should
be considered when no distinct electrograms are recorded after extensive ablation from the endocardial sites and when distinct
electrograms are recorded within the CS. 相似文献
1000.
Akira Matsuki Akihiko Igawa Takashi Nozawa Teruo Nakadate Norio Igarashi Makoto Nonomura Hiroshi Inoue 《Circulation journal》2006,70(12):1643-1649
BACKGROUND: Three-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) are known to attenuate myocardial ischemia-reperfusion (IR) injury. Fluvastatin (FV) has a potent free radical scavenging action, but it is unclear whether the timing of FV administration could affect its cardioprotective effect or if the antioxidant property of FV might attenuate IR injury. METHODS AND RESULTS: IR was induced in rats by left coronary artery occlusion for 30 min followed by 24-h reperfusion. The rats were divided into 4 groups: oral FV group (10 mg/kg per day for 2 weeks before ischemia); iv, FV group (10 mg/kg) before ischemia; iv, FV group (10 mg/kg) before reperfusion; and control group. Oxidative stress was evaluated by myocardial 8-hydroxydeoxyguanosine (8-OHdG) content. The area at risk did not different among the 4 groups. Pretreatment with FV for 2 weeks significantly reduced the infarct size by 28% as compared with the control group, but FV administered just before ischemia or reperfusion did not. Myocardial 8-OHdG content was not affected by FV. The infarct-sparing effect of FV was completely abolished by N(omega)-nitro-l-arginine methyl ester or wortmannin. CONCLUSIONS: The present results indicate that pretreatment with FV, but not just before ischemia or reperfusion, attenuates IR injury primarily through the nitric oxide pathway, not through its antioxidant property. 相似文献