全文获取类型
收费全文 | 13713篇 |
免费 | 607篇 |
国内免费 | 65篇 |
专业分类
耳鼻咽喉 | 134篇 |
儿科学 | 261篇 |
妇产科学 | 307篇 |
基础医学 | 1563篇 |
口腔科学 | 268篇 |
临床医学 | 849篇 |
内科学 | 3765篇 |
皮肤病学 | 228篇 |
神经病学 | 826篇 |
特种医学 | 336篇 |
外科学 | 2585篇 |
综合类 | 41篇 |
预防医学 | 424篇 |
眼科学 | 230篇 |
药学 | 1313篇 |
中国医学 | 12篇 |
肿瘤学 | 1243篇 |
出版年
2023年 | 81篇 |
2022年 | 159篇 |
2021年 | 281篇 |
2020年 | 139篇 |
2019年 | 190篇 |
2018年 | 222篇 |
2017年 | 204篇 |
2016年 | 254篇 |
2015年 | 247篇 |
2014年 | 316篇 |
2013年 | 414篇 |
2012年 | 622篇 |
2011年 | 710篇 |
2010年 | 373篇 |
2009年 | 366篇 |
2008年 | 584篇 |
2007年 | 572篇 |
2006年 | 567篇 |
2005年 | 578篇 |
2004年 | 586篇 |
2003年 | 569篇 |
2002年 | 555篇 |
2001年 | 445篇 |
2000年 | 433篇 |
1999年 | 383篇 |
1998年 | 158篇 |
1997年 | 101篇 |
1996年 | 89篇 |
1995年 | 82篇 |
1994年 | 85篇 |
1993年 | 72篇 |
1992年 | 348篇 |
1991年 | 295篇 |
1990年 | 300篇 |
1989年 | 313篇 |
1988年 | 297篇 |
1987年 | 298篇 |
1986年 | 260篇 |
1985年 | 209篇 |
1984年 | 187篇 |
1983年 | 149篇 |
1982年 | 79篇 |
1979年 | 154篇 |
1978年 | 84篇 |
1977年 | 75篇 |
1975年 | 83篇 |
1973年 | 67篇 |
1972年 | 73篇 |
1971年 | 81篇 |
1969年 | 71篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Cysts and tumors of the seminal vesicle are uncommon, and their coexistence is extremely rare. We report a case of multiple papillary tumors inside a seminal vesicle cyst associated with ipsilateral renal agenesis in a 17-year-old man. Surgical excision of the cyst and tumors was performed without any morbidity and histology revealed well differentiated papillary adenocarcinoma. 相似文献
72.
Summary Changes occurring in serotonin neurons during hyperthermia-induced convulsions were examined by means of a modified immunohistochemical method. All mice (8–12 weeks of age) exposed to the temperature of 50°C had convulsions, showing a generalized tonic and/or clonic pattern. Immediately after the convulsions, the animals were perfused transcardially with a fixative. A significant reduction in serotonin immunoreactivity was observed in the neostratum (caudate-putamen complex) of the mice which had hyperthermia-induced seizures, while the serotonin immunoreactivity remained unchanged in the neocortex and paleostriatum. These results suggest that serotonin may be an important mediator in the mechanism of hyperthermia-induced convulsions or that the susceptibility of serotonin neurons to a convulsive state is greatest in the neostriatum.Supported in part by Grant No. 86-05 from the National Center for Nervous, Mental and Muscular Disorders (NCNMMD) of the Ministry of Health and Welfare and Grant No. 62770677 from the Ministry of Education, Science and Culture, Japan 相似文献
73.
Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation. 总被引:1,自引:0,他引:1
Takashi Ito Yasutsugu Takada Mikiko Ueda Hironori Haga Yoji Maetani Fumitaka Oike Kohei Ogawa Seisuke Sakamoto Yasuhiro Ogura Hiroto Egawa Koichi Tanaka Shinji Uemoto 《Liver transplantation》2007,13(12):1637-1644
In the present study, the results of living donor liver transplantation (LDLT) for 125 hepatocellular carcinoma (HCC) patients were analyzed to determine optimal criteria exceeding the Milan criteria (MC) but still with predictably good outcomes. On the basis of pretransplant imaging studies, 70 patients met the MC, and 55 patients did not. Patients who exceeded the MC but presented with 相似文献
74.
Jira Chindasombatjaroen Naoya Kakimoto Hironori Akiyama Kazuko Kubo Shumei Murakami Souhei Furukawa Mitsunobu Kishino 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(6):e52-e57
The calcifying cystic odontogenic tumor is a rare benign odontogenic lesion. This report documents a case of this lesion associated with odontoma arising from the anterior maxilla in a 14-year-old boy. The diagnosis was confirmed based on computerized tomography findings, which clearly depicted the internal structures obscured in conventional images. 相似文献
75.
Mié Matsui Hiromi Yuuki Kanade Kato Ai Takeuchi Shimako Nishiyama Warren B Bilker Masayoshi Kurachi 《Journal of the International Neuropsychological Society》2007,13(4):672-682
This study compares neuropsychological functioning in a Japanese schizophrenia spectrum disorder group and a group of healthy Japanese volunteers. Participants were 37 patients diagnosed with schizophrenia, 28 schizotypal patients, and 99 psychiatrically-normal volunteers. A wide range of cognitive measures were examined. All participants completed a Japanese version of a neuropsychological battery assessing executive function, working memory, processing speed, language, verbal memory, and spatial organization. Comparisons of neuropsychological function demonstrated similarities and differences between patients diagnosed with schizotypal disorder and those diagnosed with schizophrenia. Impairments in verbal memory, language, and processing speed were common to both patient groups and may represent a vulnerability to schizophrenia. Impairments in aspects of working memory, spatial organization and executive function were preferentially observed in schizophrenia and may be features of the overt manifestation of psychosis. Possible differences in the contributions of prefrontal and temporo-limbic structures provide direction for further studies. 相似文献
76.
J Watanabe T Konishi H Takeuchi T Tomoyoshi 《Hinyokika kiyo. Acta urologica Japonica》1990,36(9):1077-1079
An 80-year-old man was admitted to our hospital with the chief complaint of urinary retention. On physical examination, a large tumor was recognized in pelvic cavity. Serum levels of prostatic acid phosphatase and gamma-seminoprotein were elevated. Anterior pelvic exenteration was performed because the tumor was huge and malignancy could not be ruled out preoperatively. The tumor weight was 660 g (11 x 8 x 7 cm) and had a multicystic structure macroscopically. Immunohistochemical study by the prostatic specific antigen stain showed positive staining in the epithelial cells of the tumor, which suggest that the tumor was of prostatic origin. 相似文献
77.
K Nagatani S Waga J Takeuchi Y Takebe K Hohda A Hirano 《Neurologia medico-chirurgica》1990,30(12):960-965
A 58-year-old female was admitted to our hospital with nausea, vomiting, and gait disturbance of 1 year duration. Postcontrast computed tomographic scans demonstrated enhanced lesions in the left cerebellopontine angle (CPA), the retrosellar region, the right parasellar region, and the left parietooccipital convexity. The left parieto-occipital tumor was totally removed in the first operation and the left CPA tumor was partially removed in the second. The histological diagnosis of both tumors was xanthogranuloma. She also had cutaneous lesions (subcutaneous nodules without tenderness) and an ureteral stenosis possibly due to the retroperitoneal involvement. A skin biopsy demonstrated infiltration of xanthoma cells and foamy cells in the dermis. A gallium scintigram demonstrated an abnormal uptake in the thoracic cavity, liver, and bones. From these findings, systemic Weber-Christian disease was diagnosed. Another unique aspect was that the serum IgE levels were increased during postoperative hospitalization. This suggests that abnormal immunological conditions are related to this disease and that intracranial xanthogranulomas are a manifestation of systemic Weber-Christian disease. 相似文献
78.
The blocking effects of d-diltiazem, its metabolites, deacetyl-d-diltiazem (d-M1), deacetyl-N-demethyl-d-diltiazem (d-M2), deacetyl-O-demethyl-d-diltiazem (d-M4) and deacetyl-N, O-demethyl-d-diltiazem (d-M6) and 1-diltiazem were investigated on the voltage-gated calcium current (ICa) of an Achatina neurone. Based on the IC50 values, the order of potency was: d-diltiazem (0.426 mM), d-M2 (0.456), d-M1 (0.491), 1-diltiazem (0.759) greater than d-M4 (1.212) greater than d-M6 (greater than 2.000). Assuming that the IC50 reflects the KD for resting Ca2+ channels (Kr), steady state activation studies gave KD values for the inactivated channels (Ki) and Kr/Ki ratios of 0.122 mM (Ki) and 3.52 (Kr/Ki) (d-diltiazem), 0.112 and 6.98 (1-diltiazem), 0.083 and 6.07 (d-M1) and 0.156 and 2.97 (d-M2). All drugs tested showed a certain degree of voltage-dependence. The further percentage reduction in the normalized ICa after high frequency stimulation demonstrated the use-dependence of: 1-diltiazem (27.5%), d-diltiazem (26.3) greater than d-M2 (19.2) greater than d-M1 (16.7) greater than d-M6 (9.8). The voltage- and use-dependence of these drugs are consistent with their Ca2+ antagonistic properties. 相似文献
79.
A CASE OF METASTATIC YOLK SAC TUMOR OF TESTIS IN A CHILD 总被引:1,自引:0,他引:1
Akito Terai Satoshi Ishitoya Takayuki Hashimura Hideo Takeuchi Osamu Yoshida 《International journal of urology》1995,2(2):135-138
We report a case of testicular yolk sac tumor in a child aged 3 years and 6 months with multiple bulky metastases to lung and retroperitoneum (stage 11182). After three courses of chemotherapy with a PV 8 regimen (cisplatin, vinblastine and bleomycin). complete and partial responses were obtained for lung and retroperitoneal lymph node metastases, respectively. The patient was followed-up closely. However, on the basis of a re-elevated alpha-letoprotein (AFP) after 4 months' follow-up, he was treated with three courses of salvage chemotherapy with a modified VAB-6 regimen (cyclophosphamide. etoposide. actinomycin D, bleomycin and cisplatin), lollowed by retroperitoneal lymph node dissection. Histologically, only necrotic tissue was found. There is no evidence of recurrence 24 months after lymphadenectomy. There is very little information in the literature on the appropriate management of postchemotherapy residual mass in pediatric testicular tumors. 相似文献
80.
Takahito Adachi Makoto Takeuchi Satomi Uno Motohisa Kato Kiichi Miya Shigetoyo Saji 《Surgery today》1997,27(12):1144-1149
Although tumor cryosurgery would be expected to produce beneficial immunological effects from the enhancement of anti-tumor
activity, under certain conditions the tumor may become enlarged and metastases promoted due to increased immunosuppressive
activity and a high zone tolerance. In the present study, we examined whether hepatocyteproliferating factors were produced
by the inoculation of freezing-thawing hepatic tissue (FTHT). Serum obtained from rats inoculated with FTHT increased DNA
synthesis, according to measurement by [3H]thymidine incorporation in primary cultured rat hepatocytes. This increase was dependent on the serum concentration, with
serum obtained on day 14 after the inoculation being the most potent for hepatocyte proliferation. The sensitized serum promoted
DNA synthesis nearly as much as serum obtained from a 70% hepatectomized rat, but slightly less than 10ng/ml hepatocyte growth
factor. The sensitized serum also protected hepatocytes from carbon tetrachloride (CCI4)-induced hepatotoxicity. Optical density measured by the 3-(4,5-dimethyl-thiazole-2-yl)-2,5-diphenyl tetrozolium bromide
(MTT) cytotoxicity assay was increased, and the release of aspartate aminotransferase, alanine aminotransferase, and lactate
dehydrogenase in medium was decreased by treating hepatocytes damaged by CCI4 with the sensitized serum. These results suggest that certain hepatocyte-proliferating and protective factors are induced
in serum by the inoculation of freezing-thawing hepatic tissue, and that the sensitized serum may be useful in the treatment
of liver failure. 相似文献