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排序方式: 共有3251条查询结果,搜索用时 15 毫秒
91.
Tomimori K Uema E Teruya H Ishikawa C Okudaira T Senba M Yamamoto K Matsuyama T Kinjo F Fujita J Mori N 《Infection and immunity》2007,75(11):5223-5232
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Surgery Today - Procalcitonin (PCT) is an early predictor of bacterial infection. We reviewed the literature and analyzed data on our own patients to assess the value of PCT as a predictor of... 相似文献
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Hatem A. Elmezayen Hirohisa Okabe Yoshifumi Baba Toshihiko Yusa Rumi Itoyama Yosuke Nakao Takanobu Yamao Naoki Umzaki Masayo Tsukamoto Yuki Kitano Tatsunori Miyata Kota Arima Hiromitsu Hayashi Katsunori Imai Akira Chikamoto Yo-ichi Yamashita Hideo Baba 《Surgery today》2020,50(6):569-576
Programmed death ligand 1 (PD-L1) is a key target for the treatment of several malignancies. The present study was conducted to clarify the role of serum PD-L1 in hepatocellular carcinoma (HCC). Serum PD-L1 (sPD-L1) was examined by an enzyme-linked immunosorbent assay in 153 patients with HCC who underwent curative hepatectomy at Kumamoto University in 2011–2016. The expression of PD-L1 in tissue (tPD-L1) was investigated by immunohistochemistry. The clinical roles of the PD-L1 expression in both serum and tissue were examined. The sPD-L1 was significantly elevated in HCC patients compared to patients without any malignant or inflammatory disease (234 vs. 93 pg/mL, p < 0.0001). The percentage of the tPD-L1-positive area (%tPD-L1) in the background liver was significantly higher than in the tumor (1.52% vs. 0.48%, p < 0.0001). The %tPD-L1 in the background liver but not in the tumor was significantly correlated with the sPD-L1 level (p = 0.0079). The sPD-L1, %tPD-L1 in the tumor, and %tPD-L1 in the background liver were not correlated with the overall survival after surgery. PD-L1-expressing cells in the background liver, but not in the tumor tissue, appeared to contribute to the sPD-L1 level. The sPD-L1 level may thus not indicate the tumor burden in patients with HCC. 相似文献
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Ryoji Furuya Satoshi Takahashi Seiji Furuya Koh Takeyama Taiji Tsukamoto 《Journal of infection and chemotherapy》2005,11(5):250-252
This is the first report of a case of seminal vesiculitis prior to acute chlamydial epididymitis. At the first visit to the
clinic, the patient wished to check whether he had Chlamydia trachomatis in his genital tract, because his wife had been diagnosed as having chlamydial cervicitis. He had no specific symptoms at
that time; however, transrectal ultrasonograpy (TRUS) revealed swelling of seminal vesicles, which suggested the presence
of seminal vesiculitis. Two days after the first visit, he had high-grade fever and was diagnosed as having acute epididymitis
caused by C. trachomatis. We had previously reported that seminal vesiculitis was always complicated with acute epididymitis, so this case could provide
important evidence that seminal vesiculitis might precede acute epididymitis. It suggested that acute epididymitis could be
affected by seminal vesiculitis via the retrograde transmission route. 相似文献
97.
Effects of alcohol consumption on multiple hepatocarcinogenesis in patients with fatty liver disease
Yorinari Ochiai M.D. Ph.D Yusuke Kawamura Masahiro Kobayashi Junichi Shindoh Yuta Kobayashi Satoshi Okubo Nozomu Muraishi Akira Kajiwara Soichi Iritani Shunichiro Fujiyama Tetsuya Hosaka Satoshi Saitoh Hitomi Sezaki Norio Akuta Fumitaka Suzuki Yoshiyuki Suzuki Kenji Ikeda Yasuji Arase Masaji Hashimoto Hiromitsu Kumada 《Hepatology research》2021,51(1):62-68
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Masuda A Nakamura K Izutsu K Igarashi K Ohkawa R Jona M Higashi K Yokota H Okudaira S Kishimoto T Watanabe T Koike Y Ikeda H Kozai Y Kurokawa M Aoki J Yatomi Y 《British journal of haematology》2008,143(1):60-70
Autotaxin (ATX) is a tumour cell motility-stimulating factor originally isolated from melanoma cell supernatants. ATX is identical to lysophospholipase D, which produces a bioactive lipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine. ATX is overexpressed in various malignancies, including Hodgkin lymphoma, and ATX may stimulate tumour progression via LPA production. The present study measured the serum ATX antigen levels in patients with haematological malignancies using a recently developed automated enzyme immunoassay. The serum ATX antigen levels in patients with B-cell neoplasms, especially follicular lymphoma (FL), were higher than those in healthy subjects. Serum ATX antigen levels in FL patients were associated with tumour burden and changed in parallel with the patients' clinical courses. The serum ATX antigen levels were little affected by inflammation, unlike the soluble interleukin-2 receptor and beta2-microglobulin levels. As expected, the plasma LPA levels in FL patients were correlated with the serum ATX antigen levels. Given that leukaemic tumour cells from FL patients expressed ATX, the shedding of ATX from lymphoma cells probably leads to the elevation of serum ATX antigen levels. Our results suggest that the serum ATX antigen level may be a promising and novel marker for FL. 相似文献