Zur Indikation der Cholecystektomie bei steinfreien Gallenblasen

Zusammenfassung Bei der Cholecystektomie der steinfreien Gallenblasen ist zwischen derrelativen und derabsoluten Indikation zur Operation zu unterscheiden. W?hrend man bei der relativen Indikation (Deformit?ten, Funktionsst?rungen, Syphopathien und dergleichen) zurückhaltend ist, sollte die absolute Indikation gro?zügig gestellt werden. Es handelt sich hierbei in erster Linie um chronische Cholecystitiden mit Wandfibrose, um benigne und maligne Tumoren, um die Cysticusstenose mit Ver?nderungen an der Gallenblase und um die Cholesterose (Stippchengallenblase). Nachuntersuchungen von Patienten, bei denen wegen steinfreier Cholesterose eine Cholecystektomie durchgeführt worden war, lie?en ein günstiges Ergebnis erkennen.

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Summary In patients undergoing cholecystectomy for gall-bladders without stones one must differentiate between therelative and theabsolute indication for surgery. Whereas one uses reservation as far as the relative indications are concerned (deformities, functional disorders, syphopathies etc.), the absolute indications should be stated more liberally. These are mainly chronic cholecystitis with fibrosis of the wall, benign and malignant tumors, duct stenosis with changes of the gallbladder and cholesterosis (strawberry gall-bladder). Follow-up examinations of patients who underwent cholecystectomy for cholesterosis without stones showed a favourable result.

     

Decreased CK1δ expression predicts prolonged survival in colorectal cancer patients

Tumor Biology - Cancers arising from the large intestine or rectum are called colorectal cancer (CRC) and represent the fourth leading cause of cancer-related death worldwide. Since casein kinase 1...     

Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R

Interaction between the extracellular matrix protein tenascin-R and the neuronal adhesion molecule F3 might be involved in the formation of neuronal networks. In this study, the fragment of tenascin-R comprising epithelial growth factor (EGF)-like repeats and the cysteine-rich NH2 terminal stretch (EGF-L), known to be inhibitory for growing neurites and repellent for growth cones, was used to investigate the signaling events following the F3/EGF-L interaction. We addressed this question using an in vitro test with F3-transfected Chinese hamster ovary (CHO) cells that allowed us to measure the kinetics, magnitude and specificity of the repellent effect resulting from the specific F3/EGF-L interaction. We showed that the repellent effect was counteracted by addition of the serine/threonine kinase and -phosphatase modulators (staurosporine, okadaic acid and H7) but not by modulators of tyrosine kinase or -phosphatases. This result indicates that the intracellular signals activated by the repellent effect involve a serine/threonine kinase pathway. Furthermore, the repellent effect of the EGF-L fragment for growth cones of cultured cerebellar neurons was also abolished by the identical modulators of serine/threonine kinase and -phosphatases. The inhibition of neurite outgrowth from hippocampal neurons by EGF-L was abolished in the presence of the serine threonine-kinase inhibitor H7. These results strongly suggest that the F3/tenascin-R interaction through EGF-L involves an intracellular activation of serine/threonine kinase(s) in all F3-expressing cells tested. J. Neurosci. Res. 49:698–709, 1997. © 1997 Wiley-Liss, Inc.     

Three-dimensional susceptibility-weighted imaging and two-dimensional T2*-weighted gradient-echo imaging of intratumoral hemorrhages in pediatric diffuse intrinsic pontine glioma

Introduction  

We compared the sensitivity and specificity of T2*-weighted gradient-echo imaging (T2*-GRE) and susceptibility-weighted imaging (SWI) in determining prevalence and cumulative incidence of intratumoral hemorrhages in children with diffuse intrinsic pontine glioma (DIPG) undergoing antiangiogenic and radiation therapy.     

Comparison of the detectability of UBOs in Neurofibromatosis Type I patients with proton density-weighted and FLAIR sequences in 3T MRI

Objective

In NF 1 patients, significant numbers of so-called unidentified bright objects (UBOs) can be found. The aim of the study was to investigate whether the detectability of UBOs increases at 3T by comparing Proton density-weighted images (PDw) with fluid-attenuated inversion recovery (FLAIR) sequences.