Plasminogen activator in bile during extracorporeal perfusion of pig liver

Plasminogen activator activity was studied in bile and perfusate during extracorporeal pig liver perfusion. Plasminogen activator activity in bile was up to 58 times greater than in perfusate. A high level of plasminogen activator activity in bile was also found after the addition of urokinase to the perfusate. These results suggest that bile is the main route of active excretion of plasminogen activator and urokinase from the liver in experimental liver perfusion.     

Spatiotemporal adaptation through corticothalamic loops: a hypothesis

The thalamus is the major gate to the cortex and its control over cortical responses is well established. Cortical feedback to the thalamus is, in turn, the anatomically dominant input to relay cells, yet its influence on thalamic processing has been difficult to interpret. For an understanding of complex sensory processing, detailed concepts of the corticothalamic interplay need yet to be established. Drawing on various physiological and anatomical data, we elaborate the novel hypothesis that the visual cortex controls the spatiotemporal structure of cortical receptive fields via feedback to the lateral geniculate nucleus. Furthermore, we present and analyze a model of corticogeniculate loops that implements this control, and exhibit its ability of object segmentation by statistical motion analysis in the visual field.     

Pathologisch-anatomische und physiologisch-chemische Untersuchungen der Extremitätenmuskulatur bei Endangitis obliterans und anderen chronisch peripheren Durchblutungstörungen

Research in Experimental Medicine - An operativ gewonnenen Extremitätenmuskeln von Patienten, die an Endangitis obliterans (E.o.) und Arteriosklerose (Art.) litten, wurde vergleichend der...     

Entwicklung,Bau und Formveränderungen der menschlichen Nasenscheidewand im fetalen Leben

Ohne ZusammenfassungMit 15 Textabbildungen     

Add-on lacosamide: a retrospective study on the relationship between serum concentration, dosage, and adverse events

We performed a retrospective study in patients with poorly controlled epilepsy treated with add-on lacosamide (LCM) to investigate the relationship of LCM-related adverse events with LCM serum concentration and weight-dependent dosage. We collected serum concentrations, weight-related dosages, and occurrences of the seven most frequent adverse events according to the randomized double-blind, placebo-controlled trials. Seventy of 131 patients could be sufficiently evaluated. LCM serum concentrations and weight-related dosages in patients with and without typical adverse events did not differ significantly. Closer analysis of the data suggested that dizziness as the leading adverse event occurred significantly more often if LCM was combined with classic sodium channel blockers. There was a significant correlation between LCM serum concentrations and co-medication, so there is still evidence for dependent variables that might have a relevant impact in individual cases. However, our data do not allow definition of a safety range for LCM.