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排序方式: 共有1825条查询结果,搜索用时 31 毫秒
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Hammer Hilde Berner Michelsen Brigitte Sexton Joe Uhlig Till Provan Sella A. 《Clinical rheumatology》2021,40(5):1739-1749
Clinical Rheumatology - The associations between fatigue and disease activity in patients with rheumatoid arthritis (RA) have not been defined. The present objectives were to explore in RA patients... 相似文献
33.
Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants 总被引:28,自引:0,他引:28
Debiec-Rychter M Cools J Dumez H Sciot R Stul M Mentens N Vranckx H Wasag B Prenen H Roesel J Hagemeijer A Van Oosterom A Marynen P 《Gastroenterology》2005,128(2):270-279
BACKGROUND AND AIMS: Resistance is a major challenge in the treatment of patients with gastrointestinal stromal tumors (GISTs). We investigated the mechanisms of resistance in patients with progressive GISTs with primary KIT mutations and the efficacy of the kinase inhibitor PKC412 for the inhibition of imatinib-resistant mutants. METHODS: We performed a cytogenetic analysis and screened for mutations of the KIT and PDGFRA kinase domains in 26 resistant GISTs. KIT autophosphorylation status was assessed by Western immunoblotting. Imatinib-resistant GIST cells and Ba/F3 cells expressing these mutant proteins were tested for sensitivity to imatinib and PKC412. RESULTS: Six distinct secondary mutations in KIT were detected in 12 progressive tumors, with V654A and T670I found to be recurrent. One progressive tumor showed acquired PDGFRA -D842V mutation. Amplification of KIT or KIT / PDGFRA was found in 2 patients. Eight of 10 progressive tumors available for analysis showed phosphorylated KIT. Two remaining progressive tumors lost KIT protein expression. GIST cells carrying KIT -del557-558/T670I or KIT -InsAY502-503/V654A mutations were resistant to imatinib, while PKC412 significantly inhibited autophosporylation of these mutants. Resistance to imatinib and sensitivity to PKC412 of KIT -T670I and PDGFRA -D842V mutants was confirmed using Ba/F3 cells. CONCLUSIONS: This study shows the high frequency of KIT/PDGFRA kinase domain mutations in patients with secondary resistance and defines genomic amplification of KIT / PDGFRA as an alternative cause of resistance to the drug. In a subset of patients, cancer cells lost their dependence on the targeted tyrosine kinase. Our findings show the sensitivity of the imatinib-resistant KIT -T670I and KIT -V654A and of PDGFRA -D842V mutants to PKC412. 相似文献
34.
Dekkers Tycho J. Huizenga Hilde M. Bult Jente Popma Arne Boyer Bianca E. 《European child & adolescent psychiatry》2021,30(4):657-669
European Child & Adolescent Psychiatry - Parents of children with ADHD experience several difficulties while raising their children and report lower levels of knowledge about their... 相似文献
35.
Ba Khadija Casolla Barbara Caparros François Bricout Nicolas Della Schiava Lucie Pasi Marco Dequatre-Ponchelle Nelly Bodenant Marie Bordet Régis Cordonnier Charlotte Hénon Hilde Leys Didier 《Journal of neurology》2021,268(1):305-311
Journal of Neurology - The epileptogenicity of recombinant tissue-plasminogen activator (rt-PA) has been suggested, but seizures were not evaluated in randomised controlled trials. To evaluate... 相似文献
36.
Cosemans Nele Maljaars Jarymke Vogels Annick Holvoet Maureen Devriendt Koen Steyaert Jean Van Den Bogaert Kris Noens Ilse Peeters Hilde 《Neurogenetics》2021,22(3):207-213
neurogenetics - A de novo 0.95 Mb 8p21.3 deletion had been identified in an individual with non-syndromic autism spectrum disorder (ASD) through high-resolution copy number variant analysis.... 相似文献
37.
Julia Menichetti Hanne C. Lie Anneli V. Mellblom Espen Andreas Brembo Hilde Eide Pål Gulbrandsen Lena Heyn Kristina H. Saltveit Hilde Strømme Vibeke Sundling Eva Turk Lene K. Juvet 《Patient education and counseling》2021,104(8):1891-1903
ObjectivesTo systematize the scientific knowledge of empirically tested strategies for verbally providing medical information in patient-physician consultations.MethodsA scoping review searching for terms related to physician, information, oral communication, and controlled study. Four pairs of reviewers screened articles. For each selected study, we assessed the quality and summarized aspects on participants, study, intervention, and outcomes. Information provision strategies were inductively classified by types and main categories.ResultsAfter screening 9422 articles, 39 were included. The methodological quality was moderate. We identified four differently used categories of strategies for providing information: cognitive aid (n = 13), persuasive (n = 8), relationship- (n = 3), and objectivity-oriented strategies (n = 4); plus, one “mixed” category (n = 11). Strategies were rarely theoretically derived.ConclusionsCurrent research of tested strategies for verbally providing medical information is marked by great heterogeneity in methods and outcomes, and lack of theory-driven approaches. The list of strategies could be used to analyse real life communication.Practice implicationsFindings may aid the harmonization of future efforts to develop empirically-based information provision strategies to be used in clinical and teaching settings. 相似文献
38.
Brustad Hilde Kjelgaard Vigeland Magnus Dehli Egeland Thore 《International journal of legal medicine》2021,135(1):117-129
International Journal of Legal Medicine - In this paper we investigate various effects of inbreeding on the likelihood ratio (LR) in forensic kinship testing. The basic setup of such testing... 相似文献
39.
Localization and determination of infarct size by Gd-Mesoporphyrin enhanced MRI in dogs 总被引:2,自引:0,他引:2
Paul Herijgers Sarra K. Laycock Yicheng Ni Guy Marchal Jan Bogaert Hilde Bosmans Carine Petr´ Willem Flameng 《The International Journal of Cardiac Imaging》1997,13(6):499-507
Background: Accurate localization and sizing of a myocardial infarction are necessary for clinical decision making and even more in research. Gd-Mesoporphyrin enhanced magnetic resonance imaging (MRI) was recently shown to specifically delineate necrosis in liver tumors, renal and muscle necrosis and myocardial infarction in rats. In this study, we investigated this technique's potential to accurately delineate myocardial infarction in a larger animal species, the dog. Methods: Myocardial infarction was induced in 8 dogs by ligation of the left anterior descending coronary artery, 4 of which were reperfused after 3 hr. Gd-Mesoporphyrin (0.05 mmol/kg) was injected intravenously 210 min after the onset of ischemia (n = 6) or after 24 hr in 2 dogs with non-reperfused infarctions. MRI was performed 10 hr. after administration of Gd-Mesoporphyrin. In vivo MRI consisted of EKG-triggered, respiratory gated T1-weighted spin echo and segmented turboFLASH long and short axis measurements. Post-mortem, a spin echo short axis measurement was repeated. Infarct size was determined planimetrically by TTC staining of left ventricular slices. Results: In all instances, there was a very close qualitative agreement between the MRI and TTC defined myocardial infarction. Quantitatively, the linear regression from post-mortem MRI to TTC determined infarct size yielded a result very close to the line of identity (regression coefficient: 0.980 ± 0.026, p<0.000001, adjusted R2 = 0.964). Conclusion: We conclude that Gd-Mesoporphyrin enhanced MRI is a promising tool for the accurate delineation of myocardial infarction. 相似文献
40.