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Andrea Zanichelli Markus Magerl Hilary J. Longhurst Werner Aberer Teresa Caballero Laurence Bouillet Anette Bygum Anete S. Grumach Jaco Botha Irmgard Andresen Marcus Maurer the IOS Study Group 《Clinical and translational allergy》2018,8(1):42
The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over time. Our findings demonstrate that some patients are still experiencing long delays to diagnosis, indicating an ongoing need for improved disease awareness. 相似文献
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Objectives: To identify common themes between general practitioners (GP's) and patients on smoking cessation in primary care in order to inform the development of acceptable guidelines, thus maximising the chance that recommendations will be received positively and implemented. Design: Qualitative study using focus groups and individual interviews with GPs and patients. Setting: North East Scotland. Subjects: 10 general practitioners and 20 patients (10 smokers and 10 patients who described themselves as ex-smokers). Results: Both general practitioners and patients agreed that the GP has a key role in providing a range of advice and support for smoking cessation. Both parties expressed views at variance with current guidelines but agreed that, for support and advice to be successful, it needs to comply with four of the five main themes identified; that it should be practical, pertinent to the consultation, personalised to the smoker's clinical need, and should emphasise the positive health gains from quitting. Conclusion: The considerable concordance between the perceptions of GPs and their patients about smoking cessation care suggests potential for a more positive partnership in working towards reduction of smoking in the UK. 相似文献
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Seyed Morteza Shamshirgaran Louisa Jorm Sanja Lujic Hilary Bambrick 《Primary Care Diabetes》2019,13(1):71-81
Background
Ethnic variation in the occurrence of type 2 diabetes, complications, mortality, and health behaviours has been reported. The current research examined patterns of health-related outcomes by country of birth in people with diabetes aged 45 years and over in New South Wales, Australia.Methods
This study was based on the baseline data of 266,848 participants aged 45 years and over from “The Sax Institute’s 45 and Up Study” (2006–2009), NSW; Australia’s most populous state. Health-related factors including self-rated overall health, Quality of Life (QoL), eyesight, subjective memory complaint, hearing loss, psychological distress and functional limitation were examined according to country of birth among 23,112 people with type 2 diabetes. Logistic regression modelling was used to compare the odds of poor outcomes between Australian-born and overseas-born participants, adjusting for potential confounding and mediating variables. Both age-sex and fully adjusted odds ratios (aORs) are reported.Results
Nearly half of the people with diabetes in the sample reported hearing loss and high levels of functional limitations, a third reported poor overall health. Compared to people with diabetes born in Australia, people born in South East Europe, North Africa, the Middle East had significantly greater odds of poor outcomes across the majority of examined health-related factors, with the largest odds observed in the elevated level of psychological distress outcome (aOR = 3.4 in North African and the Middle East group). Higher aORs of poor overall health, QoL, memory problems and poor eyesight, and lower aORs for hearing loss, were also found among those born in the Asian countries.Conclusions
The results demonstrated significant ethnic disparity in the prevalence of health-related outcomes. These findings provide important context for the formulation of culturally sensitive secondary prevention strategies. 相似文献47.
Heron SE Crossland KM Andermann E Phillips HA Hall AJ Bleasel A Shevell M Mercho S Seni MH Guiot MC Mulley JC Berkovic SF Scheffer IE 《Lancet》2002,360(9336):851-852
Ion-channel gene defects are associated with a range of paroxysmal disorders, including several monogenic epilepsy syndromes. Two autosomal dominant disorders present in the first year of life: benign familial neonatal seizures, which is associated with potassium-channel gene defects; and benign familial infantile seizures, for which no genes have been identified. Here, we describe a clinically intermediate variant, benign familial neonatal-infantile seizures, with mutations in the sodium-channel subunit gene SCN2A. This clinico-molecular correlation defines a new benign familial epilepsy syndrome beginning in early infancy, an age at which seizure disorders frequently have a sombre prognosis. 相似文献
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Eisenman DP Meredith LS Rhodes H Green BL Kaltman S Cassells A Tobin JN 《Journal of general internal medicine》2008,23(9):1386-1392
Background Little is known about how Latinos with post-traumatic stress disorder (PTSD) understand their illness and their preferences
for mental health treatment.
Objective To understand the illness beliefs and treatment preferences of Latino immigrants with PTSD.
Design Semi-structured, face-to-face interviews.
Participants Sixty foreign-born, Latino adults recruited from five primary care centers in New York and New Jersey and screened for PTSD.
Approach Content analytic methods identified common themes, their range, and most frequent or typical responses.
Results Participants identified their primary feelings as sadness, anxiety, nervousness, and fear. The most common feeling was “sad”
(triste). Other words frequently volunteered were “angry” (enojada), “nervous” (nerviosa), and “scared” (miedo). Participants viewed their PTSD as impairing health and functioning. They ascribed their somatic symptoms and their general
medical problems to the “stress” from the trauma and its consequences on their lives. The most common reason participants
volunteered for their work and school functioning being impaired was their poor concentration, often due to intrusive thoughts.
Most expressed their desire to receive mental health treatment, to receive it within their primary care center, and preferred
psychotherapy over psychotropic medications. Among participants who did not report wanting treatment, most said it was because
the trauma was “in the past.”
Conclusions Clinicians may consider enquiring about PTSD in Latino patients who report feeling sad, anxious, nervous, or fearful. Our
study suggests topics clinicians may include in the psychoeducation of patients with PTSD. 相似文献