全文获取类型
收费全文 | 2777篇 |
免费 | 202篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 97篇 |
妇产科学 | 46篇 |
基础医学 | 507篇 |
口腔科学 | 36篇 |
临床医学 | 374篇 |
内科学 | 554篇 |
皮肤病学 | 39篇 |
神经病学 | 275篇 |
特种医学 | 58篇 |
外科学 | 320篇 |
综合类 | 10篇 |
预防医学 | 265篇 |
眼科学 | 48篇 |
药学 | 169篇 |
中国医学 | 2篇 |
肿瘤学 | 171篇 |
出版年
2023年 | 26篇 |
2022年 | 27篇 |
2021年 | 78篇 |
2020年 | 62篇 |
2019年 | 77篇 |
2018年 | 80篇 |
2017年 | 53篇 |
2016年 | 80篇 |
2015年 | 74篇 |
2014年 | 85篇 |
2013年 | 152篇 |
2012年 | 213篇 |
2011年 | 237篇 |
2010年 | 107篇 |
2009年 | 117篇 |
2008年 | 166篇 |
2007年 | 184篇 |
2006年 | 162篇 |
2005年 | 152篇 |
2004年 | 156篇 |
2003年 | 158篇 |
2002年 | 155篇 |
2001年 | 20篇 |
2000年 | 19篇 |
1999年 | 22篇 |
1998年 | 32篇 |
1997年 | 23篇 |
1996年 | 14篇 |
1995年 | 24篇 |
1994年 | 11篇 |
1993年 | 7篇 |
1992年 | 9篇 |
1989年 | 5篇 |
1988年 | 9篇 |
1987年 | 6篇 |
1985年 | 6篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 11篇 |
1981年 | 7篇 |
1980年 | 6篇 |
1978年 | 10篇 |
1975年 | 10篇 |
1974年 | 7篇 |
1938年 | 5篇 |
1937年 | 7篇 |
1935年 | 5篇 |
1931年 | 7篇 |
1928年 | 7篇 |
1925年 | 4篇 |
排序方式: 共有2992条查询结果,搜索用时 31 毫秒
121.
122.
Helene Appelgren Engström PhD Catrin Borneskog Med Dr Elisabet Häggström-Nordin Med Dr Anna-Lena Almqvist PhD 《Scandinavian journal of caring sciences》2023,37(1):250-259
Background
In Sweden, antenatal and child health care are offered free of charge to all expectant and new parents. Professionals in antenatal and child health care play an important role in supporting parents. Previous research shows that same-sex mothers face heteronormative assumptions and insufficient support during their transition to parenthood.Objective
To explore professionals' experiences of supporting two-mother families in antenatal and child health care.Method
A qualitative method with focus group discussions was used. An interview guide was followed, and the discussions were held online. The data was analysed according to inductive content analysis.Settings and participants
The participants were midwives (n = 8) and nurses (n = 5) in antenatal and child health care from different parts of Sweden. Participants were recruited through the coordinating midwives and child health care nurses in the different regions.Findings
One main category was identified: Striving to be open-minded in supporting same-sex mothers. Health care professionals described meeting well-prepared mothers, with an equal commitment between each other, and mothers on guard against heteronormative views. Professionals provided support through empowerment by creating a safe environment and aiming at providing equal support to all parents or tailored support to same-sex mothers. Mothers described handling challenges, as a balancing act to acknowledge both mothers. Struggling with documents and communication and a lack of information were other challenges to be handled. Professionals reflected on their own professional competence and expressed that knowledge acquired through education, experience and personal interest all contributed to their competence.Conclusions
Forms and documentation need to be updated to be gender neutral to be including to a variety of family constelleations. Health care professionals need time to reflect on norms and challenges to better support both mothers in a two-mother family. 相似文献123.
Maria Hedmer Jan-Eric Karlsson Ulla Andersson Helene Jacobsson Jörn Nielsen Håkan Tinnerberg 《International archives of occupational and environmental health》2014,87(6):623-634
Purpose
Welding fume consists of metal fumes, e.g., manganese (Mn) and gases, e.g., ozone. Particles in the respirable dust (RD) size range dominate. Exposure to welding fume could cause short- and long-term respiratory effects. The prevalence of work-related symptoms among mild steel welders was studied, and the occupational exposure to welding fumes was quantified by repeated measurements of RD, respirable Mn, and ozone. Also the variance components were studied.Method
A questionnaire concerning airway symptoms and occupational history was answered by 79 % of a cohort of 484 welders. A group of welders (N = 108) were selected and surveyed by personal exposure measurements of RD and ozone three times during 1 year.Results
The welders had a high frequency of work-related symptoms, e.g., stuffy nose (33 %), ocular symptoms (28 %), and dry cough (24 %). The geometric mean exposure to RD and respirable Mn was 1.3 mg/m3 (min–max 0.1–38.3 mg/m3) and 0.08 mg/m3 (min–max <0.01–2.13 mg/m3), respectively. More than 50 % of the Mn concentrations exceeded the Swedish occupational exposure limit (OEL). Mainly, low concentrations of ozone were measured, but 2 % of the samples exceeded the OEL. Of the total variance for RD, 30 and 33 % can be attributed to within-worker variability and between-company variability, respectively.Conclusions
Welders had a high prevalence of work-related symptom from the airways and eyes. The welders’ exposure to Mn was unacceptably high. To reduce the exposure further, control measures in the welding workshops are needed. Correct use of general mechanical ventilation and local exhaust ventilation can, for example, efficiently reduce the exposure. 相似文献124.
125.
Molecular analysis of enterovirus in Cameroon by partial 5′UTR‐VP4 gene sequencing reveals a high genetic diversity and frequency of infections
下载免费PDF全文
![点击此处可从《Journal of medical virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
126.
Franziska Berger Helene Geddert Gerhard Faller Martin Werner Arno Dimmler 《Pathology, research and practice》2014
Purpose
Increasing evidence indicates that TGFbeta- and EGFR-signaling is involved in the pathogenesis of keratoacanthoma (KA) and squamous cell carcinoma (SCC) of the skin. We analyzed the expression pattern of TGFbeta-signaling components and screened for mutations in tgfbetaR1, egfr, kras and braf in KAs and SCCs.Methods
Immunohistochemical analysis of TGFbeta1, TGFbetaR1, TGFbetaR2 and phospho-SMAD2/3 was performed on skin tumors (29 KAs, 30 well and 31 moderately differentiated SCCs). Mutation screening in hotspot regions of tgfbetaR1, egfr, kras and braf was performed through pyrosequencing of tumor DNA.Findings
Expression of TGFbeta1, TGFbetaR1 and p-SMAD2/3 was increased in tumors as compared to surrounding skin. In KAs characteristic strong discontinuous membranous TGFbetaR1 expression pattern frequently associated with kras mutation was noted. SCCs showed continuous TGFbetaR1 expression, stronger p-SMAD2/3 expression and less frequent kras mutations. In tumors at sun-exposed sites stronger TGFbetaR1 expression was noted. One SCC showed tgfbetaR1 mutation, but no other mutations were found.Conclusion
Although tgfbetaR1 germline mutations cause inherited KAs and our finding of strong discontinuous membranous expression in KAs suggests accumulation of functionally altered protein, we found no tgfbetaR1 mutations or influence on TGFbeta-signaling, but frequent kras mutations in this subgroup of KAs. Characteristic TGFbetaR1 expression pattern in KA can facilitate histopathologic distinction from SCC. 相似文献127.
Valbona Mirakaj Christian Mutz Dierk Vagts Janek Henes Helene A. Haeberle Susanne Husung Tony König Gabriele Nöldge-Schomburg Peter Rosenberger 《Inflammation》2014,37(4):1102-1110
The hallmarks of acute lung injury (ALI) are the compromised alveolar-capillary barrier and the extravasation of leukocytes into the alveolar space. Given the fact that the peroxisome proliferator-activated receptor-γ agonist rosiglitazone holds significant anti-inflammatory properties, we aimed to evaluate whether rosiglitazone could dampen these hallmarks of local pulmonary inflammation in a porcine model of lung injury. For this purpose, we used a model of lipopolysaccharide (LPS, 50 μg/kg)-induced ALI. One hundred twenty minutes following the infusion of LPS, we started the exposure to rosiglitazone through inhalation or infusion. We found that intravenous rosiglitazone significantly controlled local pulmonary inflammation as determined through the expression of cytokines within the alveolar compartment. Furthermore, we found a significant reduction of the protein concentration and neutrophil activity within the alveolar space. In summary, we therefore conclude that the treatment with rosiglitazone might dampen local pulmonary inflammation during the initial stages of ALI. 相似文献
128.
Background
In recent years, the attention on the use of coercion in mental health care has increased. The use of coercion is common and controversial, and involves many complex ethical challenges. The research question in this study was: What kind of ethical challenges related to the use of coercion do health care practitioners face in their daily clinical work?Methods
We conducted seven focus group interviews in three mental health care institutions involving 65 multidisciplinary participants from different clinical fields. The interviews were recorded and transcribed verbatim. We analysed the material applying a ‘bricolage’ approach. Basic ethical principles for research ethics were followed. We received permission from the hospitals’ administrations and all health care professionals who participated in the focus group interviews.Results
Health care practitioners describe ethical dilemmas they face concerning formal, informal and perceived coercion. They provide a complex picture. They have to handle various ethical challenges, not seldom concerning questions of life and death. In every situation, the dignity of the patient is at stake when coercion is considered as morally right, as well as when coercion is not the preferred intervention. The work of the mental health professional is a complicated “moral enterprise”.The ethical challenges deserve to be identified and handled in a systematic way. This is important for developing the quality of health care, and it is relevant to the current focus on reducing the use of coercion and increasing patient participation. Precise knowledge about ethical challenges is necessary for those who want to develop ethics support in mental health care. Better communication skills among health care professionals and improved therapeutic relationships seem to be vital.Conclusions
A systematic focus on ethical challenges when dealing with coercion is an important step forward in order to improve health care in the mental health field.129.
Dowbiss Meta Djomsi Flaubert Auguste Mba Djonzo Innocent Ndong Bass Maëliss Champagne Audrey Lacroix Guillaume Thaurignac Amandine Esteban Helene De Nys Mathieu Bourgarel Jane-Francis Akoachere Eric Delaporte Ahidjo Ayouba Julien Cappelle Eitel Mpoudi Ngole Martine Peeters 《Viruses》2022,14(3)
The ecology of ebolaviruses is still poorly understood and the role of bats in outbreaks needs to be further clarified. Straw-colored fruit bats (Eidolon helvum) are the most common fruit bats in Africa and antibodies to ebolaviruses have been documented in this species. Between December 2018 and November 2019, samples were collected at approximately monthly intervals in roosting and feeding sites from 820 bats from an Eidolon helvum colony. Dried blood spots (DBS) were tested for antibodies to Zaire, Sudan, and Bundibugyo ebolaviruses. The proportion of samples reactive with GP antigens increased significantly with age from 0–9/220 (0–4.1%) in juveniles to 26–158/225 (11.6–70.2%) in immature adults and 10–225/372 (2.7–60.5%) in adult bats. Antibody responses were lower in lactating females. Viral RNA was not detected in 456 swab samples collected from 152 juvenile and 214 immature adult bats. Overall, our study shows that antibody levels increase in young bats suggesting that seroconversion to Ebola or related viruses occurs in older juvenile and immature adult bats. Multiple year monitoring would be needed to confirm this trend. Knowledge of the periods of the year with the highest risk of Ebolavirus circulation can guide the implementation of strategies to mitigate spill-over events. 相似文献
130.