全文获取类型
收费全文 | 2968篇 |
免费 | 152篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 79篇 |
妇产科学 | 29篇 |
基础医学 | 523篇 |
口腔科学 | 59篇 |
临床医学 | 266篇 |
内科学 | 660篇 |
皮肤病学 | 80篇 |
神经病学 | 293篇 |
特种医学 | 175篇 |
外科学 | 379篇 |
综合类 | 9篇 |
预防医学 | 171篇 |
眼科学 | 33篇 |
药学 | 166篇 |
中国医学 | 4篇 |
肿瘤学 | 198篇 |
出版年
2023年 | 17篇 |
2022年 | 34篇 |
2021年 | 68篇 |
2020年 | 44篇 |
2019年 | 57篇 |
2018年 | 60篇 |
2017年 | 44篇 |
2016年 | 61篇 |
2015年 | 86篇 |
2014年 | 112篇 |
2013年 | 155篇 |
2012年 | 249篇 |
2011年 | 232篇 |
2010年 | 136篇 |
2009年 | 123篇 |
2008年 | 213篇 |
2007年 | 179篇 |
2006年 | 176篇 |
2005年 | 150篇 |
2004年 | 123篇 |
2003年 | 135篇 |
2002年 | 123篇 |
2001年 | 49篇 |
2000年 | 40篇 |
1999年 | 47篇 |
1998年 | 47篇 |
1997年 | 27篇 |
1996年 | 28篇 |
1995年 | 13篇 |
1994年 | 10篇 |
1993年 | 11篇 |
1992年 | 24篇 |
1991年 | 19篇 |
1990年 | 26篇 |
1989年 | 22篇 |
1988年 | 22篇 |
1987年 | 20篇 |
1986年 | 12篇 |
1985年 | 14篇 |
1984年 | 9篇 |
1983年 | 12篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1931年 | 4篇 |
1926年 | 6篇 |
1925年 | 6篇 |
1919年 | 4篇 |
排序方式: 共有3137条查询结果,搜索用时 15 毫秒
31.
32.
33.
34.
Heiko Traupe Judith Fischer Vinzenz Oji 《Journal der Deutschen Dermatologischen Gesellschaft》2014,12(2):109-121
Ichthyoses are genetically determined Mendelian disorders of cornification (MEDOC) that are characterized by universal scaling. Today we distinguish between non‐syndromic and syndromic forms. Ichthyosis vulgaris is the most frequent type (prevalence 1:100) and is caused by autosomal semi‐dominant filaggrin mutations. It is associated with a higher risk for the development of atopic diseases, such as atopic eczema and allergic rhinitis. Recessive X‐linked ichthyosis (RXLI) occurs almost exclusively in boys; in Germany it has a prevalence of around 1:4,000. It is caused by steroid sulfatase deficiency and is often associated with further clinical problems, such as cryptorchidism (~20%) or social communication deficits, such as attention deficit hyperactivity syndrome (40%) or autism (25%). Autosomal recessive congenital ichthyosis (ARCI) is genetically very heterogeneous and 8 different genes have been identified so far. The most frequent cause of ARCI is a transglutaminase 1 deficiency (prevalence 1:200, 000). Mutations in keratin genes are the cause of the keratinopathic ichthyoses, such as epidermolytic ichthyosis. They manifest at birth and often feature episodes of blistering. Most of these types are inherited as autosomal dominant traits, but autosomal recessive forms have also been described on occasion. 相似文献
35.
Haemostatic profile of reconstituted blood in a proposed 1:1:1 ratio of packed red blood cells,platelet concentrate and four different plasma preparations
下载免费PDF全文
![点击此处可从《Anaesthesia》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M. Ponschab H. Schöchl C. Gabriel S. Süssner J. Cadamuro E. Haschke‐Becher J. Gratz J. Zipperle H. Redl C. J. Schlimp 《Anaesthesia》2015,70(5):528-536
The concept of haemostatic resuscitation implies early and high‐volume plasma transfusion. We investigated the haemostatic profile of reconstituted whole blood prepared in a 1:1:1 ratio of blood, platelets and plasma. This consisted of packed red blood cells, platelet concentrate and four different plasma variants: fresh frozen; solvent‐detergent; lyophilised quarantine; and lyophilised methylene blue‐inactivated plasma. Haematocrit, platelet count, endogenous thrombin potential and coagulation factor activity were significantly lower in reconstituted blood compared with citrated whole blood (p < 0.01). Except for lyophilised methylene blue‐inactivated plasma, no substantial differences between plasma variants in coagulation factor activity, endogenous thrombin potential and standard coagulation tests were observed. After reconstitution, haematocrit and platelet counts were slightly above recommended transfusion triggers, most thromboelastometry (ROTEM®) parameters were within the normal range and fibrinogen concentrations were between 1.57 g.l?1 and 1.91 g.l?1. Reconstitution of whole blood in a 1:1:1 ratio resulted in significant dilution of haematocrit and platelet count, but values remained above limits recommended by transfusion guidelines. Fibrinogen concentrations of reconstituted whole blood were also significantly reduced, and these were below the threshold value for supplementation recommended by recent guidelines. 相似文献
36.
Anja Becher 《Scandinavian journal of gastroenterology》2013,48(6):645-653
Objective. The mortality associated with malignant complications of gastroesophageal reflux disease (GERD) is well recognized. The aim of this systematic review was to assess the less well-examined mortality associated with GERD and its non-malignant complications, including esophageal erosions, ulcers, bleeding, perforation and strictures. Material and methods. Studies reporting mortality in GERD and its non-malignant complications were identified via systematic PubMed searches, and previously unpublished population mortality statistics from public access databases. Results. Three countries were examined (USA, UK, Finland). Cohort studies (n=3) in the UK showed a 1.16- to 1.6-fold increase in risk of death in individuals with GERD compared with the general population, the majority of deaths being due to cardiac disease. Population data indicate that GERD and its likely esophageal complications were the cause of death in 685 and 521 cases, respectively, in the USA (year: 2003) (age-adjusted mortality: 2.3/million and 1.8/million, respectively), and in 36 and 349 cases, respectively, in England and Wales (2004) (0.6/million and 5.4/million, respectively). In Finland (2000), GERD-related mortality was 4.6/million. Mortality from GERD and its likely esophageal complications increased with age, and was between 1.2-fold and 1.8-fold higher in men than in women. Cohort studies in the USA are inconsistent on mortality risk associated with surgical therapy. Time-trend data suggest that mortality from GERD and its non-malignant complications has been increasing. Conclusions. Data from Europe and the USA show that GERD and its non-malignant complications can on rare occasions cause death. 相似文献
37.
Oguz Akin MD Sandra B. Brennan MBBCh FRCR D. David Dershaw MD FACR Michelle S. Ginsberg MD Marc J. Gollub MD FACR Heiko Schöder MD David M. Panicek MD FACR Hedvig Hricak MD PhD 《CA: a cancer journal for clinicians》2012,62(6):364-393
Imaging has become a pivotal component throughout a patient's encounter with cancer, from initial disease detection and characterization through treatment response assessment and posttreatment follow‐up. Recent progress in imaging technology has presented new opportunities for improving clinical care. This article provides updates on the latest approaches to imaging of 5 common cancers: breast, lung, prostate, and colorectal cancers, and lymphoma. CA Cancer J Clin 2012. © 2012 American Cancer Society. 相似文献
38.
39.
40.