Socioeconomic status,individual behaviors and risk for mental disorders: A Mendelian randomization study

BackgroundThere is increasing attention on the association of socioeconomic status and individual behaviors (SES/IB) with mental health. However, the impacts of SES/IB on mental disorders are still unclear. To provide evidence for establishing feasible strategies on disease screening and prevention, we implemented Mendelian randomization (MR) design to appraise causality between SES/IB and mental disorders.MethodsWe conducted a two-sample MR study to assess the causal effects of SES and IB (dietary habits, habitual physical activity, smoking behaviors, drinking behaviors, sleeping behaviors, leisure sedentary behaviors, risky behaviors, and reproductive behaviors) on three mental disorders, including bipolar disorder, major depressive disorder and schizophrenia. A series of filtering steps were taken to select eligible genetic instruments robustly associated with each of the traits. Inverse variance weighted was used for primary analysis, with alternative MR methods including MR-Egger, weighted median, and weighted mode estimate. Complementary methods were further used to detect pleiotropic bias.ResultsAfter Bonferroni correction and rigorous quality control, we identified that SES (educational attainment), smoking behaviors (smoking initiation, number of cigarettes per day), risky behaviors (adventurousness, number of sexual partners, automobile speeding propensity) and reproductive behavior (age at first birth) were causally associated with at least one of the mental disorders.ConclusionsMR study provides robust evidence that SES/IB play broad impacts on mental disorders.     

腹腔镜辅助下食管癌根治术对患者恢复情况及凝血功能的影响

目的 探讨腹腔镜辅助下食管癌根治术对患者恢复情况及凝血功能的影响.方法 以150例食管癌患者为对象,分为对照组与观察组.对比两组术后恢复及凝血功能.结果 观察组手术时间高于对照组(P<0.05);观察组术中失血量、首次排气时间、住院时间低于对照组(P<0.05);两组淋巴结清扫数目比较未见差异(P>0.05).两组术后...     

CT定位及多靶点组合治疗强迫症临床研究

目的 研究多靶点组合对强迫症的治疗作用.方法 采用立体定向方法,运用CT定位和多靶点组合,射频热凝治疗强迫症例.采用Yale-Brown强迫症量表、Hamilton抑郁、焦虑量表对照评估.结果 42例强迫症中显效 25 例,进步 12 例.结论 双侧扣带回 双侧内囊前肢多靶点组合治疗难治性精神病的强迫症有明显的治疗作用.     

椎基底动脉延长扩张症(附4例报道)

目的 探讨椎基底动脉延长扩张症的临床表现、影像特征和治疗措施.方法 报道4例椎基底动脉延长扩张症病例,结合文献分析该病的病因、临床表现和影像学特征.结果 椎基底动脉延长扩张症是一种少见的血管性疾病,临床表现复杂多样,确诊有赖于影像检查,目前尚无针对性治疗措施.结论 应根据不同临床表现和影像学特征采用相应的治疗措施.     

联合应用垂体后叶素与肾上腺素对腹腔镜下输卵管妊娠开窗取胚术的价值

目的 探讨不同预处理方法运用于腹腔镜下输卵管妊娠开窗取胚术的安全性及可行性.方法 回顾性病例对照分析2014年10月-2018年10月120例在该院行腹腔镜下输卵管妊娠开窗取胚术的未破裂输卵管妊娠患者的临床资料,根据是否联合应用肾上腺素,将患者分为对照组(n=58)和观察组(n=62例).对照组在子宫角部偏后方与卵巢固...     

克罗恩病患者焦虑抑郁状况及其影响因素分析

目的 分析克罗恩病（Crohn’s disease, CD）患者的焦虑和抑郁状况、相关影响因素及其对患者健康生命质量的影响。方法 选择2021年2月至2022年2月就诊于复旦大学附属中山医院的CD患者共100例,采集其人口学资料及疾病相关信息。研究对象填写焦虑自评量表(SAS)、抑郁自评量表（SDS）、患者报告结局（PRO）、炎症性肠病患者生活质量问卷（IBDQ）和慢性病治疗功能评估-疲劳量表（FACIT-F）。采用卡方检验和logistic回归分析焦虑、抑郁相关影响因素;采用独立样本t检验分析焦虑、抑郁对IBDQ和FACIT-F评分的影响。结果 CD患者合并焦虑、抑郁的比例明显高于健康对照组（焦虑：58.0%vs 9.4%,P<0.001;抑郁：43.0%vs 11.8%,P<0.001）,SAS和SDS评分升高。患者为女性、具有肠外表现、疾病处于活动期（PRO2=1）为焦虑危险因素（P<0.05）;文化程度较高和疾病处于活动期（PRO2=1）是抑郁危险因素（P<0.05）。具有焦虑和抑郁情绪患者的IBDQ和FACIT-F评分明显降低（P<0.05）。结...     

冠心病患者握力 肺功能 六分钟步行试验左心室射血分数的相关性研究

目的:探讨冠心病患者握力、功能肺活量(FVC)、第一秒用力呼吸量(FEV1)、呼气峰流速(PEF)、6 min步行距离(6MWD)、左心室射血分数(LVEF)的相关性。方法:回顾性收集2017年1月至2018年12月北京医院心内科住院的冠心病患者35例,年龄(70.4±10.6)岁,根据年龄分为非老年组(<65岁)8例...     

Electrochemical Corrosion Behaviour of X70 Steel under the Action of Capillary Water in Saline Soils

In this paper, the electrochemical corrosion behavior of X70 steel in saline soil under capillary water was simulated by a Geo-experts one-dimensional soil column instrument. A volumetric water content sensor and conductivity test were used to study the migration mechanism of water and salt (sodium chloride) under the capillary water. The electrochemical corrosion behavior of the X70 steel in the corrosion system was analyzed by electrochemical testing as well as the macroscopic and microscopic corrosion morphology of the steel. The test results showed that the corrosion behavior of X70 steel was significantly influenced by the rise of capillary water. In particular, the wetting front during the capillary water rise meant that the X70 steel was located at the three-phase solid/liquid/gas interface at a certain location, which worsened its corrosion behavior. In addition, after the capillary water was stabilized, the salts were transported with the capillary water to the top of the soil column. This resulted in the highest salt content in the soil environment and the most severe corrosion of the X70 steel at this location.     

Burst Pressure Prediction of Subsea Supercritical CO2 Pipelines

To improve transportation efficiency, a supercritical CO₂ pipeline is the best choice for large-scale and long-distance transportation inshore and offshore. However, corrosion of the pipe wall will occur as a result of the presence of free water and other impurities present during CO₂ capture. Defects caused by corrosion can reduce pipe strength and result in pipe failure. In this paper, the burst pressure of subsea supercritical CO₂ pipelines under high pressure is investigated. First, a mechanical model of corroded CO₂ pipelines is established. Then, using the unified strength theory (UST), a new burst pressure equation for subsea supercritical CO₂ pipelines is derived. Next, analysis of the material’s intermediate principal stress parameters is conducted. Lastly, the accuracy of the burst pressure equation of subsea supercritical CO₂ pipelines is proven to meet the engineering requirement by experimental data. The results indicate that the parameter b of UST plays a significant role in determining burst pressure of pipelines. The study can provide a theoretical basis and reference for the design of subsea supercritical CO₂ pipelines.