全文获取类型
收费全文 | 1426篇 |
免费 | 73篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 108篇 |
妇产科学 | 23篇 |
基础医学 | 121篇 |
口腔科学 | 35篇 |
临床医学 | 91篇 |
内科学 | 247篇 |
皮肤病学 | 17篇 |
神经病学 | 77篇 |
特种医学 | 107篇 |
外科学 | 342篇 |
综合类 | 13篇 |
一般理论 | 2篇 |
预防医学 | 48篇 |
眼科学 | 46篇 |
药学 | 138篇 |
中国医学 | 7篇 |
肿瘤学 | 79篇 |
出版年
2024年 | 2篇 |
2023年 | 8篇 |
2022年 | 11篇 |
2021年 | 61篇 |
2020年 | 22篇 |
2019年 | 44篇 |
2018年 | 58篇 |
2017年 | 31篇 |
2016年 | 29篇 |
2015年 | 51篇 |
2014年 | 63篇 |
2013年 | 83篇 |
2012年 | 126篇 |
2011年 | 127篇 |
2010年 | 71篇 |
2009年 | 75篇 |
2008年 | 98篇 |
2007年 | 100篇 |
2006年 | 89篇 |
2005年 | 86篇 |
2004年 | 72篇 |
2003年 | 47篇 |
2002年 | 43篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 8篇 |
1998年 | 10篇 |
1997年 | 4篇 |
1996年 | 6篇 |
1995年 | 9篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 8篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1973年 | 1篇 |
1971年 | 2篇 |
1970年 | 1篇 |
1968年 | 3篇 |
1954年 | 1篇 |
排序方式: 共有1508条查询结果,搜索用时 31 毫秒
31.
Avantika Singh Sugandha Arya Harish Chellani K. C. Aggarwal R. M. Pandey 《Indian journal of pediatrics》2014,81(1):24-28
Objective
To evaluate the factors associated with low birth weight (LBW) and to formulate a scale to predict the probability of having a LBW infant.Methods
This hospital based case–control study was conducted in a tertiary care university hospital in North India. The study included 250 LBW neonates and 250 neonates with birth weight ≥2,500 g. Data were collected by interviewing mothers using pre-designed structured questionnaire and from hospital records.Results
Factors significantly associated with LBW were inadequate weight gain by the mother during pregnancy (<8.9 kg), inadequate proteins in diet (<47 g/d), previous preterm baby, previous LBW baby, anemic mother and passive smoking. The prediction model made on these six variables has a sensitivity of 71.6 %, specificity 67.0 %, positive LR 2.17 and negative LR of 0.42 for a cut-off score of ≥29.25. On validation, it has a sensitivity of 72 % and specificity of 64 %.Conclusions
It is possible to predict LBW using a prediction model based on significant risk factors associated with LBW. 相似文献32.
33.
Mihir Khambete Harish Kundaikar Archana Raju Sachin Lonkar Mariam Degani Mukti Kanta Ray 《Chemical biology & drug design》2019,93(1):84-88
We report the design‐synthesis of several nitrothiophene containing molecules as antituberculosis agents. The molecules were designed on the basis of previously reported nitrofuran molecules in our laboratory, and the α,β‐unsaturated linker was modified to cyclized linker in order to overcome the challenge of low solubility and possible toxicity. The stereo‐electronic properties such as HOMO, LUMO, and HOMO‐LUMO gap along with other properties such as aqueous solvation energies and QPLogS values were studied. The designed molecules were synthesized and tested for in vitro antituberculosis activity, and some molecules were found to be highly active comparable to standard drugs. Further, the aqueous solubility was determined using visual inspection method and the designed molecules were found to be more soluble than their chalcone counterparts. Cytotoxicity studies were performed and the molecules were found to be non‐cytotoxic. Electroanalytical studies proved nitro reduction as the mechanism of action for these molecules. Thus, this study provides potential nitrothiophene containing hits with improved solubility and reduced chances of toxicity. 相似文献
34.
Krishnan HR Al-Hasan YM Pohl JB Ghezzi A Atkinson NS 《Alcoholism, clinical and experimental research》2012,36(1):24-34
Background: A prevailing hypothesis is that the set of genes that underlie the endophenotypes of alcoholism overlap with those responsible for the addicted state. Functional ethanol tolerance, an endophenotype of alcoholism, is defined as a reduced response to ethanol caused by prior ethanol exposure. The neuronal origins of functional rapid tolerance are thought to be a homeostatic response of the nervous system that counters the effects of the drug. Synaptic proteins that regulate neuronal activity are an important evolutionarily conserved target of ethanol. Methods: We used mutant analysis in Drosophila to identify synaptic proteins that are important for the acquisition of rapid tolerance to sedation with ethanol. Tolerance was assayed by sedating flies with ethanol vapor and comparing the recovery time of flies after their first sedation and their second sedation. Temperature‐sensitive paralytic mutants that alter key facets of synaptic neurotransmission, such as the propagation of action potentials, synaptic vesicle fusion, exocytosis, and endocytosis, were tested for the ability to acquire functional tolerance at both the permissive and restrictive temperatures. Results: The shibire gene encodes Drosophila Dynamin. We tested 2 temperature‐sensitive alleles of the gene. The shits1 allele blocked tolerance at both the permissive and restrictive temperatures, while shits2 blocked only at the restrictive temperature. Using the temperature‐sensitive property of shits2, we showed that Dynamin function is required concomitant with exposure to ethanol. A temperature‐sensitive allele of the Syntaxin 1A gene, Syx1A3–69, also blocked the acquisition of ethanol tolerance. Conclusions: We have shown that shibire and Syntaxin 1A are required for the acquisition of rapid functional tolerance to ethanol. Furthermore, the shibire gene product, Dynamin, appears to be required for an immediate early response to ethanol that triggers a cellular response leading to rapid functional tolerance. 相似文献
35.
36.
There is paucity of literature on the relation of obesity with recurrent and chronic pancreatitis. We recorded the clinical details and the outcome of five patients with recurrent pancreatitis who had components of the metabolic syndrome. Their age ranged from 8 to 20 years. All five patients had acanthosis nigricans. Body mass index (BMI) could not be evaluated as these patients lost weight following episodes of pancreatitis. Three patients had two or more first-degree relatives who had diabetes mellitus. Only one patient had severe necrotizing pancreatitis. Coexisting liver disease was seen in two patients. Elevated serum cholesterol levels and moderately elevated serum triglycerides along with elevated serum amylase levels observed in these patients suggest possibility of a different mechanism from that of hypertriglyceridemia-related pancreatitis. Evaluation of pancreatic steatosis should be considered in patients with pancreatitis in the setting of metabolic syndrome. 相似文献
37.
B. M. Rudagi Rajshekhar Halli Yogesh Kini Viraj Kharkhar Harish Saluja 《Journal of maxillofacial and oral surgery》2013,12(2):210-213
Background
Foreign bodies embedded deep in facial tissues presents a challenge to maxillofacial surgeons. Approximately one third of all foreign bodies are missed during initial examination. After facial trauma foreign bodies like grit particles, wooden pieces, thorns, pebbles, glass particles may get embedded into deeper facial tissues which are detected only accidently either with the help of radiographs or at a later stage when patient presents with some signs & symptoms like pain, pus discharge, sinus formation etc. Trauma to maxillofacial region especially after road traffic accidents is one of major cause of embedment of foreign body, but many of these cases go unnoticed. This article contains 3 cases of foreign bodies embedded in facial tissues.Conclusion
Proper initial examination of facial lacerations with thorough debridement is very essential for finding embedded foreign bodies. Foreign bodies embedded in deeper tissues are missed by surgeon eyes, so whenever in doubt radiographs must be advised to rule out presence of foreign bodies. 相似文献38.
Harish Saluja Vipin Dehane Yogesh Kini Uma Mahindra Prafful Gaikwad 《Journal of maxillofacial and oral surgery》2013,12(3):312-314
Aim of the study was to find out the number of miniplates used by Indian Oral and Maxillofacial Surgeons for parasymphysis fractures. A survey was done among Oral and Maxillofacial Surgeons of India at the 34th annual meeting of Association of Oral and Maxillofacial Surgeons of India. Four questions were given to each individual to find out their opinion regarding use of miniplates in parasymphysis fractures. Eighty-eight per cent of Indian surgeons were in favour of using intra-operative or post-operative intermaxillary fixation. Thirty-eight per cent responded in favour of using single miniplate for parasymphysis fracture instead of using two miniplates. Fifty-four per cent maxillofacial surgeons use various modifications depending on different conditions. Forty-two per cent of maxillofacial surgeons accepted that lower arch bar can be used as a tension band. Use of miniplates for the treatment of parasymphysis fracture varies from centre to centre and from surgeon to surgeon. Though miniplates are best used following Champy’s principle, still many surgeons use single miniplate. Arch bars placed for intermaxillary fixation can be used as a tension band, again eliminating the need for upper plate. 相似文献
39.
Shafagh Monazzam MD Mandar Agashe MD Harish S. Hosalkar MD 《Clinical orthopaedics and related research》2013,471(8):2578-2585
Background
Multiple radiographic parameters used for diagnosis and quantification of morphologic pincer features have emerged, but the degree to which pelvic tilt or rotation affects conventional radiography and EOS® is unknown.Question/purposes
We asked: (1) What is the reliability of EOS® and conventional radiography at increasing sizes of morphologic pincer features with varying degrees of tilt and rotation? (2) What is the effect of tilt and rotation on acetabular overcoverage measurements?Methods
Using a dry cadaveric pelvis, AP conventional radiographs and EOS® images were taken at intervals of increasing modeled pincer size with 0° to 15° varying tilt and rotation. Lateral center-edge angle, Sharp angle, Tönnis angle, crossover sign, and retroversion index were measured on all images. Statistical analysis was conducted.Results
The intermodality intraclass correlation coefficients for conventional radiography and EOS® radiography across all pincer sizes, rotations, and tilts were excellent (0.93–0.98). Crossover sign was in perfect agreement in conventional radiography and EOS®. Rotation of the hip away from the beam source and/or increased anterior tilt falsely increased all overcoverage parameters except for Tönnis angle. Rotation away from the beam of 10°or greater or anterior tilt of 5° or greater produced a false-positive crossover sign.Conclusions
EOS® radiography maintained excellent reliability in comparison to conventional radiography but both were equally vulnerable to the effects of tilt and rotation for quantification of hip parameters used in acetabular overcoverage assessment. A standardized pelvic radiograph ensuring that the pelvis is not excessively tilted or rotated should be used for assessing acetabular overcoverage parameters. 相似文献40.
Shafagh Monazzam MD James D. Bomar MPH Mandar Agashe MD Harish S. Hosalkar MD 《Clinical orthopaedics and related research》2013,471(5):1639-1645