全文获取类型
收费全文 | 1073篇 |
免费 | 89篇 |
国内免费 | 66篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 69篇 |
妇产科学 | 155篇 |
基础医学 | 119篇 |
口腔科学 | 13篇 |
临床医学 | 133篇 |
内科学 | 187篇 |
皮肤病学 | 15篇 |
神经病学 | 28篇 |
特种医学 | 124篇 |
外科学 | 126篇 |
综合类 | 50篇 |
预防医学 | 66篇 |
眼科学 | 17篇 |
药学 | 84篇 |
中国医学 | 1篇 |
肿瘤学 | 38篇 |
出版年
2023年 | 11篇 |
2022年 | 5篇 |
2021年 | 12篇 |
2020年 | 4篇 |
2019年 | 8篇 |
2018年 | 12篇 |
2017年 | 8篇 |
2016年 | 13篇 |
2015年 | 22篇 |
2014年 | 23篇 |
2013年 | 35篇 |
2012年 | 44篇 |
2011年 | 32篇 |
2010年 | 39篇 |
2009年 | 51篇 |
2008年 | 52篇 |
2007年 | 78篇 |
2006年 | 49篇 |
2005年 | 47篇 |
2004年 | 35篇 |
2003年 | 34篇 |
2002年 | 27篇 |
2001年 | 20篇 |
2000年 | 24篇 |
1999年 | 30篇 |
1998年 | 39篇 |
1997年 | 44篇 |
1996年 | 30篇 |
1995年 | 27篇 |
1994年 | 19篇 |
1993年 | 29篇 |
1992年 | 13篇 |
1991年 | 23篇 |
1990年 | 30篇 |
1989年 | 37篇 |
1988年 | 23篇 |
1987年 | 27篇 |
1986年 | 26篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 10篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 16篇 |
1979年 | 17篇 |
1978年 | 6篇 |
1976年 | 7篇 |
1974年 | 10篇 |
1972年 | 7篇 |
1969年 | 4篇 |
排序方式: 共有1228条查询结果,搜索用时 15 毫秒
91.
92.
Berlowitz MS Latif F Hankins SR Ennezat PV Moskowitz R Tandon S Colombo PC Le Jemtel TH 《Journal of cardiovascular pharmacology》2001,37(6):692-696
Losartan, an angiotensin II type 1 receptor (AT1) antagonist, was developed as a more specific alternative to angiotensin-converting enzyme (ACE) inhibitors. At a daily dose of 50 mg, losartan is currently evaluated in large outcome trials involving patients with hypertension and postmyocardial infarction. The current study evaluated the level and duration of blockade of a pressor response to angiotensin II by 50 and 150 mg of losartan, compared with 32 mg of candesartan. Eight normotensive volunteers were randomly assigned to a single dose of losartan 50 or 150 mg, candesartan 32 mg, or placebo. Subjects were re-randomized after a 2-week washout period to complete all four study arms. Radial artery systolic pressure response to exogenous angiotensin II was measured at 2, 6, 12, and 24 h after administration of drug. Losartan 50 mg reduced the pressure response to exogenous angiotensin II significantly only at 6 h. In contrast, candesartan and losartan 150 mg produced a greater reduction in the pressure response to angiotensin II throughout the 24-h period. This suppression was not paralleled by a reduction in resting systemic arterial pressure. Higher doses than 50 mg of losartan might be evaluated to elicit optimal clinical effects. 相似文献
93.
Diet and cancer prevention: the fiber first diet 总被引:3,自引:0,他引:3
Diet can play a major role in cancer prevention. The international
differences in cancer incidence are largely accounted for by lifestyle
practices that include nutrition, exercise, and alcohol and tobacco use.
About 50% of cancer incidence and 35% of cancer mortality in the U.S.,
represented by cancers of the breast, prostate, pancreas, ovary,
endometrium, and colon, are associated with Western dietary habits. Cancer
of the stomach, currently a major disease in the Far East, relates to
distinct, specific nutritional elements such as excessive salt intake. For
these cancers, information is available on possible initiating genotoxic
factors, promoting elements, and prophylactic agents. In general, the
typical diet in the United States contains low levels of the potent
carcinogenic agents, heterocyclic amines, formed during the cooking of
meats. It provides only about half the potent appropriate fiber intake and
is high in calories. About twice as many calories as would be desirable
come from fat, certain kinds of which enhance the development of cancers.
Other foods with functional properties, such as soy products and tea, can
be beneficial. To achieve reduction in risk of certain cancers, diet must
be optimized, primarily to reduce caloric intake and the fat component. The
latter should be 20% or less of total caloric intake and fiber should be
increased to 25- 35 g per day for adults. One approach to achieving these
goals is the Fiber First Diet, a diet designed around adequate fiber intake
from grains, especially cereals, vegetables, legumes, and fruits, which
thereby reduces both calorie and fat intake. Such dietary improvements will
not only reduce cancer and other chronic disease risks, but will contribute
to a healthy life to an advanced age. A corollary benefit is a lower cost
of medical care.
相似文献
94.
95.
96.
97.
98.
D G Hankins K Saxena R J Faville B J Warren 《The American journal of emergency medicine》1987,5(2):165-166
Isoniazid (INH) is the cause of one of the most common serious drug overdoses and can cause severe metabolic acidosis. We report a case of INH overdose that is most notable because the patient survived without apparent sequelae after experiencing an extremely low pH level (6.49). This is the lowest reported pH level with patient survival. Toxicity and pharmacology of INH and various aspects of metabolic acidosis are discussed. 相似文献
99.
100.
Stephanie O. Ibemere Charity I. Oyedeji Liliana Preiss Laura E. Van Althuis Jane S. Hankins Melissa Azul Ebony N. Burns Jeffrey Glassberg Ward Hagar Faiz Hussain Allison King Cathy Melvin John Myers Angela Snyder Nirmish Shah Paula Tanabe Sickle Cell Disease Implementation Consortium 《British journal of haematology》2023,200(5):633-642
Individuals with sickle cell disease (SCD) have historically been considered underweight. Despite increasing body mass index (BMI) in the general population, the prevalence of overweight and obese status remains unclear in the adult SCD population. Our primary aim was to determine the prevalence of overweight and obese status and to identify associations between BMI, demographic, and clinical characteristics. We conducted an analysis of abstracted electronic health record data and patient-reported outcomes from the Sickle Cell Disease Implementation Consortium registry; individuals aged 20–45 years were included. The median (interquartile range) BMI for the 1664 adults in this analysis was 23.9 (21.1–28) kg/m2. In this cohort, 42.9% had a BMI of >25 kg/m2 (Centers for Disease Control and Prevention definition of overweight/obese). In multivariable analysis, higher odds of being overweight or obese were associated with female gender, older age, college education, private insurance, and hypertension diagnosis. Higher odds of a BMI of >25 kg/m2 were observed in individuals with HbSC or HbSβ+ thalassaemia regardless of hydroxycarbamide (hydroxyurea) exposure (odds ratio [OR] 3.4, p < 0.0001) and HbSS or HbSβ0 thalassaemia exposed to hydroxycarbamide (OR 1.6, p = 0.0003) compared to those with HbSS or HbSβ0 thalassaemia with no hydroxycarbamide exposure. These data highlight the importance of early identification, prevention, and intervention for increasing BMI to reduce obesity-related complications that may impact SCD-related complications. 相似文献