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991.
Ahmed M. Maged Wesam Sayed Deeb Sahar Elbaradie Ahmed R. Elzayat Ahmed A. Metwally Mohamed Hamed Ahmed Shaker 《Taiwanese journal of obstetrics & gynecology》2018,57(3):346-350
Objective
To compare the effect of local infiltration and intravenous dexamethasone on postoperative pain and recovery after Cesarean Section (CS).Material and methods
A Prospective, randomized study conducted on 120 pregnant women attending the labor wards. All participants were scheduled for elective CS under spinal anaesthesia and were randomly divided into 3 equal groups. Group 1 received 16 mg Dexamethasone IV drip. Group II received 16 mg Dexamethasone subcutaneous injection around the caesarean section scar after skin closure and Group III received Placebo (500 cc saline infusion). All cases were followed up for 48 h for assessment of level of pain by using a 10-cm visual analog scale (VAS). Primary outcome parameters were VAS score and the need for additional analgesics. Other parameters were hemodynamic changes and occurrence of side effects or complications.Results
there was a highly statistically significant difference between placebo and local infiltration groups and between the placebo and IV groups regarding the needs for postoperative morphine. Comparing both interventional groups revealed statistically significant difference between local infiltration and IV groups regarding the needs for postoperative morphine.Conclusion
Local infiltration of dexamethasone is more effective than systemic administration to decrease postoperative pain with weaker antiemetic effect.NCT02784340. 相似文献992.
Shahin Shadnia Nasim Zaman Hossein Hassanian-Moghaddam Hamed Shafaroodi Mina Padandar Mohammad Hasan Rezaeizadeh 《世界急诊医学杂志(英文)》2018,9(1):51
BACKGROUND: Prognostic value of cortisol and thyroid function tests (TFTs) has previously been evaluated in medical ICUs. We aimed to evaluate prognostic efficacy of cortisol and TFTs in critically ill poisoned patients admitted to toxicology intensive care unit (ICU).METHODS: In a prospective study of consecutively enrolled subjects admitted to the toxicology ICU, lab analyses included TFTs (total T3 and T4 as well as TSH) and cortisol levels drawn between 8 am-10 am during period of the first 24 hours post-ingestion/exposure. Simplified Acute Physiology Score II (SAPS II) and Acute Physiology and Chronic Health Evaluation II (APACHE II) were recorded. All scores were compared to detect the best prognostic factor. Type of poisoning was also included.RESULTS: In 200 patients evaluated, 129 were male and mean age was 31 years. In general, SAPS II, T4, and cortisol could prognosticate death. After regression analysis, only cortisol had such efficacy (P=0.04; OR=1.06; 95%CI=1.05-1.08; cut-off=42 μg/dL; sensitivity=70%; specificity=82%). Between aluminium phosphide (ALP)- and non ALP-poisoned patients, level of consciousness, mean arterial pressure, and cortisol level could prognosticate death in ALP poisoning (all Ps<0.001 in both uni and multivariate analyses). Median (interquartile range; IQR) GCS was 7 (6, 10) and 15 (8, 15) in non-ALP and ALP-poisoned patients (P<0.003). SAPS II and APACHE II could not prognosticate death at all.CONCLUSION: Cortisol best prognosticated outcomes for subjects admitted to the toxicology ICU. Its level is higher in ALP-poisoned patients probably due to the higher stress while they remain conscious till the final stages of toxicity and are aware of deterioration of their clinical condition or may be due to their significantly lower blood pressures. 相似文献
993.
Esfandiari Hamed Pakravan Mohammad Amouhashemi Nassim Yaseri Mehdi Torkian Pooya Jadidi Khosrow Loewen Nils A 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2018,256(11):2173-2179
Graefe's Archive for Clinical and Experimental Ophthalmology - To evaluate the association between baseline ocular variables and the widening of the anterior chamber angle by laser peripheral... 相似文献
994.
Zarei Mohammad Abdollahi Ali Darabeigi Sahel Ebrahimiadib Nazanin Roohipoor Ramak Ghassemi Hamed Moghaddam Reza Soltani Fard Masoud Aghsaei 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2018,256(12):2421-2427
Graefe's Archive for Clinical and Experimental Ophthalmology - To investigate optic nerve head involvement in patients with Fuchs uveitis syndrome (FUS). Optic nerve head of 43 FUS eyes without... 相似文献
995.
996.
Szyndler J Maciejak P Turzyńska D Sobolewska A Lehner M Taracha E Walkowiak J Skórzewska A Wisłowska-Stanek A Hamed A Bidziński A Płaźnik A 《Neuroscience letters》2008,439(3):245-249
It is not well recognized how disturbances in the local metabolism of some amino acids, especially glutamate and GABA, may lead to seizures. In the presented study, we have examined changes in the hippocampal steady state concentrations of amino acids involved in pentylenetetrazole-kindled and freely moving rats. It was found that in the kindled animals, the concentration of alanine, arginine, glutamate, aspartate and taurine was increased in the interictal period of seizures compared to the control group, whereas kindling reduced the extracellular levels of GABA. No differences between kindled and not-kindled animals in the glycine, histidine and glutamine levels were present. There also appeared an over fourfold increase of the Glu/GABA ratio, a theoretical marker of the neuronal excitation level, in the kindled animals. A multivariate classification tree analysis showed that the hippocampal concentration of taurine, together with GABA and Glu, had the relatively largest prediction accuracy in discriminating between kindled and non-kindled animals, suggesting a specific role of these amino acids in the shaping of a new equilibrium between excitatory and inhibitory processes in the hippocampus of kindled animals. 相似文献
997.
Tatenobu Goto Mohamed Hamed Hussein Shin Kato Ghada Abdel-Hamid Daoud Takenori Kato Hiroki Kakita Haruo Mizuno Masaki Imai Tetsuya Ito Ineko Kato Satoshi Suzuki Noriko Okada Hajime Togari Hidechika Okada 《Intensive care medicine》2010,36(12):2132-2139
Purpose
To evaluate effects of endothelin receptor antagonist ETR-P1/fl in a neonatal sepsis model.Method
Eighteen anesthetized and mechanically ventilated 3-day-old piglets were divided into three groups. Six piglets received cecal ligation and perforation (CLP group). Six piglets were administrated a continuous infusion of ETR-P1/fl (0.05 mg/kg/h), an antisense homology box-derived peptide with an endothelin A receptor antagonist effect, starting 30 min after CLP (ETR-P1/fl group). Six piglets acted as the sham group. Mean arterial pressure (MAP), heart rate, cardiac output, arterial blood gas, body temp (BT), serum nitrite and nitrate (NOx), tumor necrosis factor (TNF)-α, and high-mobility group box 1 (HMGB-1) were measured before CLP and at 1, 3, 6, and 9 h after CLP.Results
Cecal ligation and perforation exposure evoked a state of shock and showed deteriorated cardiac output, pulmonary hypertension, decreased MAP, low oxygen saturation, and base excess (BE) with elevated TNF-α, NOx, and HMGB1. ETR-P1/fl administration resulted in higher MAP at 6 and 9 h after CLP, less negative BE, lower mean pulmonary arterial pressure (mPAP)/MAP ratio at 9 h after CLP, and lower TNF-α, NOx, and HMGB-1 compared to the CLP group. BT showed no differences between the groups. Survival time in the ETR-P1/fl group was longer than in the CLP group (18.9 ± 2.3 h vs. 9.0 ± 0.8 h, p < 0.01).Conclusions
ETR-P1/fl treatment significantly attenuated the elevation of NOx, TNF-α, and HMGB-1, which improved the systemic hypotension, pulmonary hypertension, and blood gases, thereby causing improvement of survival time in a progressive neonatal sepsis CLP model. 相似文献998.
Quantitative and Topographical Study of Retinal Ganglion Cells in the Chameleon (Chameleo chameleon)
Chameleons display a number of well-described physiological peculiarities of their visual system, but there is no information on the topography of the retinal ganglion cell layer. In the present study, ganglion cell density of the chameleon retina was constructed from whole mounts of the retina stained with cresyl violet. For the identification of ganglion cells, these latter cells were labelled retrogradely with horseradish peroxidase applied to the optic nerve. Using this criterion, the proportion of ganglion cells was estimated to represent 80% of retinal cells, while glial cells and amacrine cells represented 14 and 6%, respectively, of the total cell population of the retina. As for the main features of the retinal map, first, ganglion cells were distributed inhomogeneously within the ganglion cell layer, and revealed the existence of a putative area centralis. Second, a horizontal visual streak, which showed two peak density areas, was identified. These features point out the degree of specialisation of the chameleon retina and the complexity of its visual system. 相似文献
999.
Adel A.-H. Abdel-Rahman Hamed M. Abdel-Bary Erik B. Pedersen Claus Nielsen 《Archiv der Pharmazie》1995,328(1):67-70
Silylated 4-methylthiouracil and 4-methylthiothymine were condensed in the presence of TMS triflate with methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-D-erythro-pentofuranoside ( 3 ) and methyl 3-azido-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-D-erythro-pentofuroside ( 8 ), respectively, to give the corresponding nucleosides which were deprotected. The 3′-azido nucleoside was reduced with triphenylphosphine to the corresponding 3′-amino nucleoside. The 3′-amino nucleoside was also obtained by condensation of 4-methylthiothymidine with a 3-phthalimido sugar 14 followed by deprotection. The 4-methylthio analogue 11 of AZT showed moderate activity against HIV. 相似文献
1000.
Associated neurologic and ophthalmologic findings in congenital oculomotor nerve palsy 总被引:2,自引:0,他引:2
L M Hamed 《Ophthalmology》1991,98(5):708-714
Unlike acquired oculomotor nerve palsy in childhood, the congenital form is usually considered to be an isolated disorder, not associated with other neurologic or systemic disease. In a series of 14 patients with this diagnosis, 10 had associated neurologic disorders. Clinical-neuroradiologic correlation identified the brainstem as the site of the lesion in some patients. The ipsilateral pupil was involved in 12 patients and was miotic with a trace or no reaction to light on the side of the palsy in 8 of the 12 patients. In two of these eight patients, the pupil was documented to be dilated and fixed in early infancy and subsequently became miotic at several months of age, concurrent with emergence of other signs of aberrant reinnervation. Pupillary miosis as a result of aberrant reinnervation appears to be much more frequent after congenital than acquired pupillary-involving oculomotor palsy. Four patients showed better visual acuity in the paretic eye, an unexpected finding. The paretic eye appeared to have a fixational advantage if the patient had nystagmus, presumably due to asymmetric dampening of the nystagmus. Significant anisometropia and astigmatic errors in the paretic eye were present in essentially all patients. 相似文献