球压试验关键操作技术环节分析

目的明确球压试验操作重点,避免出现测量偏差。方法对球压试验的关键操作技术环节进行介绍和分析,并进行了测量不确定度的评估。结果与结论球压试验受人员操作影响非常大,加强环节控制和人员训练非常重要。     

Antler Transformation is Advanced by Inversion of Antlerogenic Periosteum Implants in Sika Deer (Cervus nippon)

Deer antlers offer a unique model for the study of tissue‐specific stem cells and organogenesis, as antler stem cells are confined to the antlerogenic periosteum (AP), a tissue that can be readily located (overlying a frontal crest) and experimentally manipulated. AP consists of an upper fibrous layer and a lower cellular layer. Tissue transplantation and membrane insertion experiments demonstrated that antler formation is triggered by the interactions between AP and the overlying skin. Interestingly, fairly normal antlers can be induced to grow by an inverted AP implant (the AP cellular layer facing the skin) at an ectopic site, raising the question whether the initial inductive signal is derived from the fibrous layer or cellular layer or both. To answer this question, in this study we used eight sika deer stag calves and selected one side of future antler growth region for implanting inverted AP and the contralateral side for noninverted AP as the control. The results showed that implantation of the AP discs in an inverted orientation generated pedicles with final height (17 ± 5.1 mm), less than half the height of those formed from the noninverted AP implants (45 ± 11.7 mm). Critically, antler transformation was initiated from a shorter pedicle, which was formed from the region where the AP cellular layer was brought in close proximity to the overlying skin. Therefore, the AP cellular layer, as opposed to the AP fibrous layer, is likely to be the main source of the initial inductive molecules for antlerogenesis. Anat Rec 293:1787–1796, 2010. © 2010 Wiley‐Liss, Inc.     

Allelopathic Effects of <Emphasis Type="Italic">Myriophyllum aquaticum</Emphasis> on Two Cyanobacteria of <Emphasis Type="Italic">Anabaena flos-aquae</Emphasis> and <Emphasis Type="Italic">Microcystis aeruginosa</Emphasis>

Allelopathy has been proposed as a sustainable means to control undesired algal growth and to reduce blooms threatening freshwater systems worldwide. In this study, the allelopathic effects of Myriophyllum aquaticum and its exudate on two typical bloom-forming cyanobacteria, Microcystis aeruginosa and Anabaena flos-aquae, were investigated under laboratory conditions. The growth of the cyanobacteria was strongly inhibited by live M. aquaticum while the primary addition of M. Aquaticum exudates had a significant inhibitory effect on the growth of M. aeruginosa but not A. flos-aquae. The results suggested that the persistent release of allelochemicals from live M. aquaticum was needed to effectively constrain the growth of A. flos-aquae. Analysis of cyanobacterial physiological indexes indicated that M. aquaticum produced an inhibitory effect on SOD enzyme activity of A. flos-aquae, while it affected membrane lipid peroxidation in M. aeruginosa. The results show the potential of M. aquaticum to mitigate cyanobacterial blooms in coexistence systems.     

国家人口计生委科技司召开避孕药具不良反应监测试点工作启动会议

为贯彻落实《计划生育技术服务管理条例》,在计划生育系统逐步建立和实施避孕药具不良反应监测报告制度,保障育龄群众避孕安全,推进以人为本优质服务工作的开展,2005年9月24~25日,国家人口计生委科技司在南京召开了避孕药具不良反应监测试点工作启动会议。10个承担避孕药具不良     

心房粘液瘤临床病理观察(附四例报告)

作者应用组织化学、免疫组织化学方法对４例经改良低温心内直视手术切除的心房粘液瘤临床病理特征进行了观察分析。结果表明，心房粘液瘤是分化良好的真性肿瘤，形态结构具多样性、复杂性，自原始幼稚间叶组织发生，向不同方向分化，应与血栓机化区别。临床表现常有与二尖瓣狭窄相似症状，应与风湿病鉴别。作者对心房粘液瘤的生物学行为、治疗及预后问题进行了讨论。     

肠外营养支持中药学质量保障体系的建立

在总结和分析医院静脉药物配置中心建立和实施药学质量监控方法及取得初步成效的基础上 ,对肠外营养支持中药学质量保障体系的建立和作用进行探讨 ,以保证其临床使用的安全、有效、经济     

基于FAERS数据库的阿普米司特风险信号挖掘与分析

目的 通过对美国食品药品管理局（FDA）不良事件报告系统（FAERS）挖掘阿普米司特的风险信号，为临床使用的安全性提供参考依据。方法 采用报告比值比法（ROR）和贝叶斯可信区间递进神经网络（BCPNN）对美国FAERS数据库中2014年第1季度—2023年第3季度阿普米司特相关不良事件（ADE）进行数据挖掘和分析。结果 共检索出阿普米司特相关ADE报告70 075份，以女性病例（61.4%）为主，年龄主要集中18～65岁（34.6%）；上报国家主要以美国（96.5%）为主；经筛选出阳性信号70个，涉及12个系统器官（SOC）；挖掘出的信号提示阿普米司特相关ADE报告主要集中在胃肠系统疾病、各类神经系统疾病、精神病类、感染及侵染类疾病，频数发生较多的PT主要是腹泻、恶心、头痛、腹部不适等；信号较强的PT主要是紧张性头痛、腹泻、排便频率增加、粪便松软、腹部不适等；新的风险信号有38个，包括潜伏性结核、病毒性胃肠炎、耳部感染、上呼吸道充血、痛风等。结论 使用阿普米司特应在治疗期间，重点关注患者的胃肠道反应，同时评估患者的精神状况，监测有感染、肾脏不全功能患者的使用，以保证治疗的安全性。     

单头胸锁乳突肌肌皮瓣在口腔颌面部的应用研究

目的：从肌皮动脉“缘支”同样也是肌皮瓣血供主要来源这一观点出发，在手术设计上将肌皮瓣的肌蒂改为复合组织蒂，并提出保护“缘支”的手术方法，安全地扩大了应用皮瓣的面肌。方法：通过对50具（100例）成人尸体进行解剖学观察与测量。为临床设计胸锁乳突肌胸骨头肌皮瓣提供解剖学依据。结果：根据胸锁乳突肌两个头的可分离性，要中安全切取单头胸锁乳突肌皮瓣，修复口腔颌面部组织缺损获得成功。结论：本术式可保留胸锁乳突肌锁骨头的生理功能，防止术后出现“歪颈”，而且有的病例采用胸骨头代替嚼肌，通过保留其运动神经，感觉神经，使已缺损的嚼肌、舌肌的生理功能得到恢复。     

丹红注射液治疗慢性充血性心力衰竭42例

目的:评价丹红注射液治疗充血性心力衰竭(CHF)的治疗效果。方法:将42例NYHAⅡ-Ⅳ级CHF患者随机分为两组,每组21例。对照组采用强心、利尿及血管紧张素转换酶抑制剂和倍他乐克治疗;治疗组在对照组的基础上加用丹红注射液30mL两周,观察两组治疗前后临床疗效。结果:治疗组临床显效率47.62%,有效率47.62%,无效率4.765%;对照组分别为40.47%、40.47%和19.05%(P<0.05)。治疗后与治疗前相比,两组心能等指标均有显著性改善(P<0.001和P<0.05),血压与治疗前比较有下降。结论:在充血性心力衰竭常规治疗基础上加用丹红注射液治疗CHF是安全的,能改善心功能,提高患者活动耐量,减少心率失常发生。