全文获取类型
收费全文 | 254篇 |
免费 | 14篇 |
专业分类
儿科学 | 51篇 |
妇产科学 | 1篇 |
基础医学 | 15篇 |
口腔科学 | 3篇 |
临床医学 | 26篇 |
内科学 | 75篇 |
皮肤病学 | 10篇 |
神经病学 | 15篇 |
外科学 | 43篇 |
综合类 | 3篇 |
预防医学 | 2篇 |
药学 | 14篇 |
肿瘤学 | 10篇 |
出版年
2018年 | 1篇 |
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 10篇 |
2014年 | 9篇 |
2013年 | 4篇 |
2012年 | 2篇 |
2011年 | 1篇 |
2010年 | 6篇 |
2009年 | 7篇 |
2007年 | 10篇 |
2006年 | 20篇 |
2005年 | 5篇 |
2004年 | 7篇 |
2003年 | 8篇 |
2002年 | 6篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 5篇 |
1998年 | 14篇 |
1997年 | 26篇 |
1996年 | 24篇 |
1995年 | 27篇 |
1994年 | 10篇 |
1993年 | 14篇 |
1992年 | 6篇 |
1991年 | 7篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1955年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有268条查询结果,搜索用时 828 毫秒
61.
OSAMU UKIMURA AKIHIRO KAWAUCHI AKIRA FUJITO YOICHI MIZUTANI KOJI OKIHARA KAZUYA MIKAMI JINTETSU SOH TERUKAZU NAKAMURA HIROYUKI NAKANISHI SO USHIJIMA TSUNEHARU MIKI 《International journal of urology》2004,11(12):1051-1057
OBJECTIVE: Although radio-frequency ablation (RFA) has been recently applied as a minimally invasive treatment option for renal cell carcinoma (RCC), indication of this modality remains a critical issue due to the lack of complete tumor destruction as well as the uncertainty of its long-term efficacy. We report the efficacy of RFA for nine carefully selected patients with RCC who had significant reason to avoid invasive surgical treatment under general anesthesia. METHODS: Radio-frequency ablation was performed under epidural or local anesthesia by ultrasound or computed tomography (CT) guidance in nine patients with biopsy proven RCC (mean diameter, 38 mm; range, 20-53 mm), who were at significant operative or anesthetic risk for invasive surgery. Follow-up enhanced CT scans or magnetic resonance images were evaluated every 3-6 months and an evaluation of metastasis was performed every 6 months. RESULTS: At a mean follow-up of 17 months, seven (78%) of the nine patients with renal tumor showed no tumor enhancement. The renal function of all patients was well preserved. All patients were able to continue undergoing their respective treatments for active diseases in other organs in parallel to the RFA treatment. No distant metastasis, urine leakage were reported and one case of temporary hematuria and one case of peri-renal hemorrhage not requiring blood transfusion were encountered. Intra-operative ultrasonography was useful in the real-time monitoring of the minimally excessive extension of ablation into the normal parenchyma. CONCLUSION: Radio-frequency ablation appears to be an effective and safe minimally invasive therapeutic option for selected patients with RCC who have reason to avoid invasive surgery under general anesthesia. 相似文献
62.
63.
KATSUHIRO MABE HARUHIDE SHINZAWA KEIICHI YAMATANI TADASHI TAKEDA MASAMICHI ISHIBASHI NOBUO YAMADA HIROYUKI MISAWA HIROTO WAKABAYASHI HITOSHI TOGASHI TSUNEO TAKAHASHI 《Journal of gastroenterology and hepatology》1997,12(7):551-553
A 54-year-old woman who was being treated with 10 million units (mu) of natural interferon (IFN)-α per day for chronic active hepatitis C at a local clinic, developed coma on the fourth day of treatment. On admission to Yamagata University Hospital, she was still in a state of semicoma with severe hyponatraemia (122 mEq/L) and hypochloraemia (89 mEq/L). After the administration of electrolytes, her condition improved remarkably. Endocrinological loading tests showed a hypofunction of the anterior pituitary gland. In consideration of these results, and her past experiences of haemorrhage during childbirth and subsequent amenorrhoea, we diagnosed her illness as a coma as a result of Sheehan's syndrome which had become overt during IFN therapy. She recovered completely after treatment with hydrocortisone and 1-thyroxine. 相似文献
64.
65.
WARD JERROLD M.; TSUDA HIROYUKI; TATEMATSU MASAE; HAGIWARA AKIHIRO; ITO NOBUYUKI 《Toxicological sciences》1989,12(1):163-171
Hepatotoxicity of Agents That Enhance Formation of Focal HepatocellularProliferative Lesions (Putative Preneoplastic Foci) in a RapidRat Liver Bioassay. WARD, J. M., TSUDA, H., TATEMATSU, M., HAGIWARA,A., AND ITO, N. (1989). Fundam Appl Toxicol. 12., 163171.The histopathology of hepatic toxicity for 58 chemicals previouslytested in a rapid rat liver bioassay for demonstrating potentialhepatocellular carcinogens and/or tumor promoters was reviewed.Rats received the test diet for 1 week prior to partial hepatectomyand for an additional 5 weeks thereafter at doses near the estimatedmaximally tolerated dose. These rats served as controls forothers receiving initiation by N-nitrosodiethylamine (DEN) andthe test diets. Twenty-two of these chemicals were previouslyfound to enhance the formation of glutathione S-transferase,placental form (GST-P)-positive putative preneoplastic hepatocellularfoci (promoters) following DEN initiation in this rapid bioassay,whereas 36 chemicals did not. Of the agents that promoted GST-P-positivefoci, 14/22 (63.6%) produced toxic hepatocyte lesions whileonly 4/36(11.1%) of the nonpromoters did so at the doses used.Biliary toxicity was found for 7/22 (31.8%) of the promotersand 6/36 (16.7%) of the nonpromoters. Only 2/13 (15%) chemicalsthat inhibited GST-P-positive foci produced hepatic toxicity.Thus, agents that were presumed hepatic tumor promoters characteristicallywere hepatotoxins while nonpromoters of carcinogenesis werenot hepatotoxins in this rapid rat liver bioassay. 相似文献
66.
Efficacy and Safety of Apixaban in the Patients Undergoing the Ablation of Atrial Fibrillation
下载免费PDF全文
![点击此处可从《Pacing and clinical electrophysiology : PACE》网站下载免费的PDF全文](/ch/ext_images/free.gif)
TOMOYUKI NAGAO M.D. YASUYA INDEN M.D. Ph.D. MASAYUKI SHIMANO M.D. Ph.D. MASAYA FUJITA M.D. SATOSHI YANAGISAWA M.D. HIROYUKI KATO M.D. SHINJI ISHIKAWA M.D. AYA MIYOSHI M.D. SATOSHI OKUMURA M.D. SHIOU OHGUCHI M.D. TOSHIHIKO YAMAMOTO M.D. NAOKI YOSHIDA M.D. Ph.D. MAKOTO HIRAI M.D. Ph.D. TOYOAKI MUROHARA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2015,38(2):155-163
67.
68.
69.
70.
TARO KONO MD HENRY H. CHAN MD FRCP WILLIAM FREDERICK GROFF DO HIROYUKI SAKURAI MD MASAKI TAKEUCHI MD TAKASHI YAMAKI MD KAZUTAKA SOEJIMA MD MOTOHIRO NOZAKI MD 《Dermatologic surgery》2007,33(8):945-950
BACKGROUND AND OBJECTIVE: The 595-nm long-pulsed dye laser (LPDL) has been used for the treatment of vascular lesions, and although it is well absorbed by blood, it is also well absorbed by melanin. To utilize this device for the treatment of facial lentigines, we attached a glass window to the tip of the laser's handpiece, allowing compression of the skin during treatment. This prospective study aims to evaluate the efficacy and complications of using a LPDL delivered with compression for the treatment of facial lentigines in Asian persons. MATERIALS AND METHODS: Fifty-four Asian patients with facial lentigines were enrolled in this study. The laser settings included fluences between 9 and 13 J/cm(2) and a constant pulse duration of 1.5 ms. Cryogen spray cooling was not used. RESULTS: Thirty-eight patients showed excellent results, 14 patients showed good results, and 2 patients showed fair results. Hyperpigmentation was seen in 1 patient. CONCLUSION: LPDL delivered with the compression method is effective in the treatment of facial lentigines in Asian patients, and the side effect profile is minimal. The compression technique allows the traditional "vascular" LPDL to be used for treating a variety of pigmented lesions. 相似文献