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11.
SYUJI TAKEI NOBUAKI MAENO MASAHIKO SHIGEMORI HIROYUKI IMANAKA HIROSUMI MORI YASUHITO NEROME SYOKO KANEKURA TOMOKO TAKEZAKI MASASHI HOKONOHARA KOICHIRO MIYATA SATOSHI FUJIKAWA 《Pediatrics international》1997,39(2):250-256
Marked advances have been made in the past decade in the management of adults with systemic lupus erythematosus (SLE). Therefore, a nationwide retrospective survey was conducted between 1980 and 1994 to investigate the clinical manifestations of SLE in Japanese children and adolescents. Questionnaires were sent to 340 hospitals. Of 405 patients reported by 176 hospitals, 373 patients, diagnosed by the criteria established by the Pediatric Study Group of the Japanese Ministry of Health and Welfare in 1985, were enrolled in the study. Forty-nine of the 354 patients (13.8%) had relatives with a connective tissue disease within the third degree of consanguinity. The frequent manifestations in 373 patients were the presence of antinuclear antibody (98.9%), immunologic disorders (93.0%), hypocomplementemia (87.1%), malar rash (79.6%) and fever (74.0%). Lupus nephritis was present in 148 of the 309 patients (47.9%) at their first visit to a clinic, and 261 of the 373 patients (70.0%) developed renal involvement during the observation period. Of 370 patients, 92 patients (24.9%) exhibited central nervous system lupus. Of 368 patients, 192 patients (52.2%) were treated by methylprednisolone pulse therapy and 148 patients (40.2%) received immunosuppressants in combination with steroid therapy at some stage during the observation period. Survival rate at 5 years from onset was 95.9%. Management of infection, coagulopathies, and central nervous system involvement is essential to improve the prognosis of SLE in Japanese children and adolescents. 相似文献
12.
13.
SHU TAKABATAKE M.D. KENSHI HAYASHI M.D. CHIAKI NAKANISHI M.D. HIROYUKI HAO M.D. KENJI SAKATA M.D. MASA‐AKI KAWASHIRI M.D. TAKEHISA MATSUDA Ph.D. MASAKAZU YAMAGISHI M.D. 《Journal of interventional cardiology》2014,27(1):63-72
Objectives
We evaluated the in vivo performance of a newly devised vascular endothelial growth factor (VEGF)‐bound stent in a porcine coronary model.Background
An anti‐CD34 antibody‐bound stent, which captures endothelial progenitor cells (EPCs) to accelerate tissue formation, did not reduce intimal hyperplasia. By targeting the VEGF receptor, which is expressed on endothelial‐lineage cells, we developed VEGF‐bound stents that may enable selective capture of EPCs followed by rapid endothelialization.Methods
Metallic stents were first coated with poly‐(ethylene‐co‐vinyl alcohol), and then chemically bound with either VEGF or anti‐CD34 antibody. These stents were placed in porcine coronary arteries for up to 14 days. Stent surface was evaluated by immunohistochemistry and by scanning electron microscope (SEM).Results
After 2‐day stenting with VEGF‐bound stents, small populations of KDR (VEGF receptor‐2)‐positive cells adhered to the stent struts. After 7‐ and 14‐day stenting, struts were fully covered with newly regenerated tissue. SEM images showed that the uniform tissue formed on struts was morphologically similar to native endothelium and was continuously connected with adjacent native endothelium. On the other hand, for the anti‐CD34 antibody‐bound stents, stent struts were rapidly covered by newly generated tissue that consisted of multicellular aggregates.Conclusions
Compared with anti‐CD34 antibody‐bound stents, VEGF‐bound stents provide highly selective capture of EPCs, followed by rapid formation of intact endothelium tissue at an early period of stenting. These results suggest that VEGF‐bound stents could represent a promising therapeutic option for cardiovascular stenting, although further long‐term follow‐up experiment with double‐blinded fashion is needed prior to clinical application. (J Interven Cardiol 2014;27:63–72)14.
Yuko NAKAGAWA Akiomi INOUE Norito KAWAKAMI Kanami TSUNO Kimiko TOMIOKA Mayuko NAKANISHI Kosuke MAFUNE Hisanori HIRO 《Industrial health》2014,52(6):471-479
This study investigated the cross-sectional association of job demands (i.e.,
psychological demands) and job resources (i.e., decision latitude, supervisor support,
co-worker support, and extrinsic reward) with job performance. A total of 1,198 workers
(458 males and 740 females) from a manufacturing company in Japan completed a
self-administered questionnaire that included the Job Content Questionnaire, Effort-Reward
Imbalance Questionnaire, World Health Organization Health and Work Performance
Questionnaire, and demographic survey. Hierarchical multiple regression analyses were
conducted. After adjusting for demographic characteristics, decision latitude
(β=0.107, p=0.001) and
extrinsic reward (β=0.158,
p<0.001) were positively and significantly associated
with job performance while supervisor support (β=−0.102,
p=0.002) was negatively and significantly associated
with job performance. On the other hand, psychological demands or co-worker support was
not significantly associated with job performance. These findings suggest that higher
decision latitude and extrinsic reward enhance job performance among Japanese
employees. 相似文献
15.
TAISHI KUWAHARA M.D. ATSUSHI TAKAHASHI M.D. YOSHIHIDE TAKAHASHI M.D. ATUSHI KOBORI M.D. SHINSUKE MIYAZAKI M.D. ASUMI TAKEI M.D. TADASHI FUJINO M.D. KENJI OKUBO M.D. KATSUMASA TAKAGI M.D. AKIRA FUJII M.D. MASATERU TAKIGAWA M.D. YUJI WATARI M.D. HIROYUKI HIKITA M.D. AKIRA SATO M.D. KAZUTAKA AONUMA M.D. 《Journal of cardiovascular electrophysiology》2013,24(5):510-515
16.
NAOTO ADACHI KOHJI KIWAKI HIROYUKI TSUCHIYA MASAHIRO MIGITA TOSHIMI YOSHIMOTO ICHIRO MATSUDA 《Pediatrics international》1995,37(2):211-216
Fatal cytomegalovirus (CMV) myocarditis occurred in a 2 year old boy with acute lymphoblastic leukemia (ALL) in remission. The patient showed mild hepatic dysfunction and a rapid progress of pancytopenia after complete remission had been achieved. At the fifth week of complete remission, he presented signs of heart failure such as tachycardia, S4 gallop on auscultation and decreased ejection fraction on echocardiography. However, no significant electrocardiographic changes were recognized. In addition to the cardiac dysfunction, the patient presented a marked tachypnea and dyspnea associated with hypoxemia. These were dramatically improved by methylprednisolone pulse therapy (30 mg/kg per day, for 3 days) and CMV high titer immunoglobulin (400 mg/kg per day, for 3 days). On the sixth day after signs of respiratory failure were improved, the patient suddenly presented a paroxysmal atrial tachycardia followed by a fatal ventricular fibrillation. Although we could detect neither a specific IgM antibody, a significant increase of IgG antibody, nor CMV genome by DNA hybridization techniques during the course of the illness, microscopic examination of necropsy specimens of the heart showed a marked disruption and disintegration of muscle bands associated with cytomegalic inclusion bodies. Polymerase chain reaction (PCR) yielded a 305 bp amplification product in the heart and lung tissues, supporting the view that myocarditis was caused by CMV. 相似文献
17.
GABRIELE MARGOS KLAUS KURTENBACH † ELSA POSNETT GUY C. BARKER HIROYUKI MATSUOKA MICHAEL G. PATON ROBERT E. SINDEN 《Parasite immunology》1995,17(4):167-176
A surface protein of Plasmodium berghei ookinetes, Pbs21, was expressed in a baculovirus-insect cell system in cell culture and in Heliothis virescens larvae. Groups of BALB/c mice received two intraperitoneal inoculations of either i) Tris-buffer or homogenized H. virescens larvae infected with wild-type baculovirus; ii) enriched, homogenized ookinetes, or Hi) homogenizedH. virescens larvae expressing recombinant Pbs21 (rPbs21). All animals immunized with ookinetes or with rPbs21 had high litres of antibodies (IgG isotype) that bound to native Pbs21. The large majority of antibodies in immune sera of both groups recognized the antigen under non-reducing but not under reducing conditions. The predominant IgG-sub-classes in mice immunized with ookinetes was IgGl and in mice immunized with rPbs21, the subclasses were IgGl and IgG2a. Immunization with rPbs21 reduced the infec-tivity of P. berghei to mosquitoes by 91% compared to a 99% reduction following immunization with ookinetes. This preliminary data indicate that rPbs21 expressed in this eukaryotic system induces a transmission-blocking immunity which is more effective than that achieved using rPbsll expressed in Escherichia coli (Matsuoka et al. 1994). 相似文献
18.
ICHIRO KAMIOKA KANDAI NOZU TERUO FUJITA HIROSHI KAITO RYOJIRO TANAKA KUNIHIKO YOSHIYA KAZUMOTO IIJIMA KOICHI NAKANISHI NORISHIGE YOSHIKAWA MASAFUMI MATSUO 《Pediatrics international》2007,49(2):196-201
BACKGROUND: The three major signs of hemolytic uremic syndrome (HUS) are hemolytic anemia, thrombopenia and acute renal failure. HUS is classified into Shiga toxin-mediated HUS (Stx-HUS) and non-Shiga toxin-mediated HUS (nStx-HUS). The prognosis of nStx-HUS is reported to be less favorable than that of Stx-HUS. Although the association between the prognosis and pathological characteristics of HUS have been reported such that the prognosis was considered to be poor for thrombotic microangiopathy (TMA) with predominant arterial involvement (arterial TMA), good for TMA with predominant glomerular involvement (glomerular TMA) and dependent on the extent of necrosis in cases of renal cortical necrosis, it is not yet clear whether pathological findings are also related to the renal prognosis of nStx-HUS cases. Therefore the purpose of the present paper was to analyze renal biopsy findings and prognosis for five children with nStx-HUS. METHODS: Clinical records of five cases of nStx-HUS among 74 cases of diagnosed HUS were reviewed, and information and data were summarized. RESULTS: Histological examination of the kidney led to the diagnosis of arterial TMA in three cases, and glomerular TMA and severe renal cortical necrosis in one case each. Analysis of the relationship between renal histological findings and the prognosis found that three patients with arterial TMA and one patient with severe renal cortical necrosis later developed end-stage renal failure while one patient with glomerular TMA has continued to show normal renal function. CONCLUSIONS: These findings indicate that pathological findings are closely related to the prognosis in cases of nStx-HUS. 相似文献
19.
HIROYUKI ABE TAIJI NISHIMURA TAKAFUMI MIURA TAKUSHI UCHIKOBA TOMOYASU OHNO NORIYUKI ISHIKAWA KIMIYOSHI YOKOI YOSHIHARU OHAKI 《International journal of urology》2002,9(10):599-601
BACKGROUND: We report here an extremely rare case of cystosarcoma phyllodes of the seminal vesicle. METHODS: A 65-year-old man presented with urinary hesitancy, frequency and constipation. Clinical examinations including two needle biopsies were performed, and the patient had undergone open surgery. RESULTS: The final pathological diagnosis was cystosarcoma phyllodes of the seminal vesicle. Seven months after the operation, a chest X-ray showed lung metastasis, and the patient died 11 months after the operation. CONCLUSION: To our knowledge, only one case of cystosarcoma phyllodes of the seminal vesicle has been previously reported. 相似文献
20.
SHIMIZU HIROYUKI; HISAMICHI SHIGERU; MOTOMIYA MASAKICHI; OIZUMI KOTARO; KONNO KIYOSHI; HASHIMOTO KUNIHISA; NAKADA TASUKU 《Japanese journal of clinical oncology》1986,16(2):117-121
Smoking habits of the 827 lung cancer patients aged 40 yearsor over who were treated in the Sendai Kosei Hospital from 197782were compared with those in the general population of a non-metropolitandistrict in northern Japan, which we recently surveyed by mailquestionnaire. The relative risks of lung cancer by histologictype adjusted by age and area of residence were as follows:1.9 for adenocarcinoma, 4.3 for squamous cell carcinoma, 3.9for small cell carcinoma and 3.4 for large cell carcinoma inmen, and 2.9, 6.4, 4.5 and 4.0 for these histologic types, respectively,in women. These elevated risks were all statistically significant(p < 0.05). These findings suggest that smoking habits shouldbe carefully considered when studying the etiology of any celltype of lung cancer, even adenocarcinoma, which often has beenthought to be unrelated to smoking habits. 相似文献