全文获取类型
收费全文 | 189篇 |
免费 | 10篇 |
专业分类
儿科学 | 43篇 |
基础医学 | 9篇 |
口腔科学 | 3篇 |
临床医学 | 23篇 |
内科学 | 53篇 |
皮肤病学 | 4篇 |
神经病学 | 11篇 |
外科学 | 30篇 |
综合类 | 3篇 |
预防医学 | 1篇 |
药学 | 10篇 |
肿瘤学 | 9篇 |
出版年
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 8篇 |
2014年 | 5篇 |
2013年 | 4篇 |
2012年 | 1篇 |
2011年 | 1篇 |
2010年 | 2篇 |
2009年 | 3篇 |
2007年 | 9篇 |
2006年 | 14篇 |
2005年 | 4篇 |
2004年 | 7篇 |
2003年 | 7篇 |
2002年 | 4篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 6篇 |
1998年 | 14篇 |
1997年 | 18篇 |
1996年 | 22篇 |
1995年 | 21篇 |
1994年 | 4篇 |
1993年 | 8篇 |
1992年 | 4篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有199条查询结果,搜索用时 515 毫秒
161.
HIROYUKI SHICHINO HIDEO MUGISHIMA MAYUMI TAKAMURA TOSHIAKI SHIMADA TAKASHI SUZUKI MOTOAKI CHIN KENSUKE HARADA SIGEO RYO SEIJI KOJIMA 《Pediatrics international》1996,38(6):644-647
The main purpose of the present study was to determine the response rate to immunosuppressive therapy combined with recombinant human granulocyte-colony stimulating factor (rhG-CSF) and its efficacy for preventing infections in patients with severe aplastic anemia. The treatments included one course of antithymocyte globulin, cyclosporin A, methylprednisolone, danazole and rhG-CSF. Three patients had very severe aplastic anemia and two had moderate aplastic anemia. One patient relapsed 13 months following the first course of therapy and received a second course. Five patients received six courses of treatment and the response rate at 6 months was 83.3%. All patients achieved an absolute neutrophil count of greater than 1.0 × 109/L within 40 days. All patients with a complete response are transfusion-free and doing well. All five patients are currently alive and have not had any episode of infection for 17–53 months. The results of the study indicate that this therapy may improve the poor prognosis of young patients with severe aplastic anemia. It has a good response rate and induces a rather rapid increase in the neutrophil count, which protects against life-threatening bacterial and fungal infections. 相似文献
162.
163.
Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy
下载免费PDF全文
![点击此处可从《Journal of cardiovascular electrophysiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
TETSUO KONNO M.D. Ph.D. KENSHI HAYASHI M.D. Ph.D. NOBORU FUJINO M.D. Ph.D. RIE OKA M.D. Ph.D. AKIHIRO NOMURA M.D. YOJI NAGATA M.D. AKIHIKO HODATSU M.D. KENJI SAKATA M.D. Ph.D. HIROSHI FURUSHO M.D. Ph.D. MASAYUKI TAKAMURA M.D. Ph.D. HIROYUKI NAKAMURA M.D. Ph.D. MASA‐AKI KAWASHIRI M.D. Ph.D. MASAKAZU YAMAGISHI M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2015,26(10):1081-1087
164.
Apixaban versus Warfarin for the Prevention of Periprocedural Cerebral Thromboembolism in Atrial Fibrillation Ablation: Multicenter Prospective Randomized Study
下载免费PDF全文
![点击此处可从《Journal of cardiovascular electrophysiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
TAISHI KUWAHARA M.D. MITSUNORI ABE M.D. MASARU YAMAKI M.D. HIROYUKI FUJIEDA M.D. YUMIKO ABE M.D. KATSUSHI HASHIMOTO M.D. MISAKO ISHIBA M.D. HIROTSUKA SAKAI M.D. KEIICHI HISHIKARI M.D. MASATERU TAKIGAWA M.D. KENJI OKUBO M.D. KATSUMASA TAKAGI M.D. YASUAKI TANAKA M.D. JUN NAKAJIMA M.D. ATSUSHI TAKAHASHI M.D. 《Journal of cardiovascular electrophysiology》2016,27(5):549-554
165.
TADASHI IWAO ATSUSHI TOYONAGA HIROYUKI SHIGEMORI KAZUHIKO OHO MICHIHIRO SUMINO MASAHIRO SATO KYUICHI TANIKAWA 《Journal of gastroenterology and hepatology》1996,11(3):216-222
The effects of vasopressin plus oxygen and vasopressin alone on gastric mucosal perfusion and oxygenation were studied using reflectance spectrophotometry and laser Doppler velocimetry in 23 cirrhotic patients with portal-hypertensive gastropathy. The measurements were performed under basal conditions and after double-blinded administration of placebo (n= 7), vasopressin (0.3 U/min; n= 8) or vasopressin (0.3 U/min) plus nasal oxygen (4 L/min; n= 8). No significant effects on gastric mucosal haemodynamics and oxygenation were observed after placebo. In contrast, vasopressin and vasopressin plus oxygen induced a similar reduction in haemoglobin content (-26 ± 2 and -21 ± 4%, respectively P < 0.01) and laser Doppler signal (-23 ± 2 and -22 ± 2%, respectively, P < 0.01). Although each treatment induced a significant reduction in oxygen saturation (-21 ± 2 and -7 ± 1%, respectively P < 0.01), the effect was less pronounced in patients receiving the combination than in those receiving vasopressin alone (P < 0.01). These data suggest that vasopressin and vasopressin plus oxygen reduce gastric mucosal hyperaemia and that the oxygen supplement partially protects against gastric mucosal hypoxia during vasopressin infusion in cirrhotic patients with portal-hypertensive gastropathy. 相似文献
166.
167.
SHIGENORI HIGUCHI YASUHIDE YANABE HIROYUKI TSUCHIYA IZUMI AKAHOSHI KEIJI UDAKA MASAHIRO MIGITA ICHIRO MATSUDA 《Pediatrics international》1993,35(1):39-44
A 6 month old boy was diagnosed as a case of combined immunodeficiency (with predominant T cell defect by previous classification). His T cell count was decreased, his B cell count in peripheral blood was increased, his serum IgG level was decreased, his serum IgM level was normal and the thymus was not evident on CT scans and magnetic resonance imaging. Administration of the thymus hormone, thymosin, led to a partial recovery of T cell function without normalization of the T cell count. At age 26 months the patient received an irradiated thymus transplantation from a 16 week old female fetus. After the transplantation, the T cell count (mainly CD4+ cells) increased by 50–70%. A mild graft-versus-host reaction (GVHR) occurred and several immunosuppressants were prescribed. Chromosome analysis showed that the T cells have both 46 XY and 46 XX karyotypes while the B cells have the 46 XY karyotype alone. His cellular immunity (skin tests, DNA synthesis, mixed lymphocyte reaction, cytotoxic activity and natural killer cell function) and his serum IgG level remained low. However, being on regular r-globulin therapy and oral anti-fungal drugs, he is now living normally with almost no trouble at age 6 years and 3 months. This case showed that irradiated thymus transplantation might be a useful method when an adequate donor for bone marrow transplantation is not available. The unexpected observation that the increased T cells were mainly CD4 may be related to the mild GVHR and the clinical improvement. 相似文献
168.
HIROYUKI TOCHIMARU KAZUE YASUDA YASUO TAKEKOSHI SHUZO MASTUMOTO 《Pediatrics international》1993,35(5):480-487
Lupus nephritis is a major predictor of the prognosis of systemic lupus erythematosus (SLE). The present paper discusses lupus nephritis from clinical and immunopathological points of view. Although recent advances in diagnosis and treatment improve the prognosis of children with SLE, there remain many unsolved clinical problems. One of the current topics in the treatment for SLE is intermittent intravenous cyclophosphamide therapy which is effective even for the steroid-resistant patients with severe lupus nephritis, at least for short-term observation. Immunopathologically, the following issues are discussed: (i) The C5b-9 terminal complement complex plays an important role in the pathogenesis of lupus nephritis. The possible interaction of vitronectin and SP-40,40 is also mentioned; (ii) A semi-quantitative analysis of the charge barrier of the glomerular basement membrane reveals that the charge barrier dysfunction plays an important role in the pathogenesis of proteinuria in lupus nephritis. This study also demonstrates that the charge of immune deposits is important for the initiation of glomerular injury in lupus nephritis; (iii) It is demonstrated that the histopathological diversity of lupus nephritis is based on biological properties of nephritogenic autoantibodies in murine lupus models. 相似文献
169.
IWAO YAMAGIWA MAKOTO IWAFUCHI KAZUYA OBATA HIROYUKI SAITO 《Pediatrics international》1996,38(5):506-512
In order to investigate the possibility of early discrimination of extrahepatic biliary atresia from other cholestatic diseases, a series of results of liver function tests in infants with cholestatic diseases were reviewed. The results of routine liver function tests (LFT) recorded in patients' charts were reviewed within 12 weeks after birth in 47 infants with extrahepatic biliary atresia (BA), 10 infants with neonatal hepatitis (NH) and 130 age-matched control infants (CO) without cholestatic diseases. The mean of each test value for each week after birth was derived from the actual data examined in each infant. No differences were observed between BA and CO in the levels of aminotransferases within 2 weeks after birth. Total bilirubin and direct bilirubin levels were significantly different between BA and CO within 1 week after birth (16.1 ± 3.2 mg/dL vs 11.1 ± 4.5 mg/dL, 4.6 ± 2.6 mg/dL vs 0.7 ± 0.3 mg/dL, respectively) The direct bilirubin-total bilirubin ratio exceeded 25% within the first week in BA. The individual values of direct bilirubin (DB) exceeded 2 mg/dL within the first week in all infants with BA, while none of the individual values exceeded 1.6 mg/dL in CO. Gamma-glutamyl transpeptidase levels were significantly different between BA and CO at 4 weeks (432 ± 272 IU/L vs 79 ± 43 IU/L) and thereafter; and were significantly different between BA and NH at 6 weeks (314 ± 232 IU/l vs 69 ± 58 IU/L) and thereafter. These data suggest that the determination of direct bilirubin within 1 week after birth can detect extrahepatic biliary atresia patients from those with physiologic jaundice, and γ-glutamyl transpeptidase levels may discriminate BA from NH at no later than 6 weeks of age. 相似文献
170.
HIROYUKI TSUCHIYA KOKO GOTO NAOKI YUNOHARA MARIKO MATSUOKA MASAYO NISHIOKA YASUKO NAKAMURA YOKO FUKUDA FUMIO ENDO KAZUO MATSUI 《Pediatrics international》2006,48(6):604-607
BACKGROUND: Hearing loss is one of the most common abnormalities present at birth. The authors examined the frequency of newborn hearing disturbance at a single obstetric hospital to exclude technical varieties or varieties of subjects which are inevitable in multiple institutional cooperative studies. METHODS: The newborns were examined with an automated auditory brainstem response screener, the ALGO 2e, on day 4 post-partum. This Screener uses 35 dB near hearing level click stimuli and provides a PASS/REFER result that requires no interpretation. The PASS result is accepted as adequate evidence of hearing and REFER result as required further diagnostic testing to determine hearing status. Screenings of REFER outcomes were repeated at 1 month of age. Comparisons were made of the results and the Japanese multiple institutional trials by Mann-Whitney U-test. RESULTS: The authors screened 8979 out of 13 494 neonates born from July 1999 to October 2004. The neonates with unilateral or bilateral REFER outcomes were 37 cases (0.41% of the total examined) on day 4, and 31 cases (0.35%) at 1 month of age. Five of the 31 neonates had PASS outcomes at 6 months of age. Among the 31 REFER neonates, eight (25.8%) had otolaryngeal complications. CONCLUSION: In the present study, screening results at 1 month of age resembled the final diagnosis obtained at 6 months of age; out of 31 REFER cases, 26 cases were diagnosed with hearing loss. In contrast, in the multiple institutional study, both unilateral and bilateral REFER rates were much higher than the rates of final hearing loss. Concerning the final diagnoses of bilateral hearing loss, the authors' results (0.10%) and the multiple institutional studies' results (0.05% in low-risk and 2.19% in high-risk neonates) were comparable to the results reported in the USA. To expand the newborn hearing screening program, it is crucial that authority and institutions concerned promote the development of a national or prefecture-based early hearing loss identification and intervention network. 相似文献