全文获取类型
收费全文 | 7501篇 |
免费 | 471篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 84篇 |
儿科学 | 211篇 |
妇产科学 | 168篇 |
基础医学 | 1059篇 |
口腔科学 | 561篇 |
临床医学 | 674篇 |
内科学 | 1519篇 |
皮肤病学 | 196篇 |
神经病学 | 528篇 |
特种医学 | 152篇 |
外科学 | 903篇 |
综合类 | 46篇 |
一般理论 | 1篇 |
预防医学 | 704篇 |
眼科学 | 186篇 |
药学 | 645篇 |
中国医学 | 55篇 |
肿瘤学 | 311篇 |
出版年
2023年 | 70篇 |
2022年 | 179篇 |
2021年 | 298篇 |
2020年 | 181篇 |
2019年 | 224篇 |
2018年 | 286篇 |
2017年 | 176篇 |
2016年 | 227篇 |
2015年 | 279篇 |
2014年 | 361篇 |
2013年 | 412篇 |
2012年 | 596篇 |
2011年 | 680篇 |
2010年 | 325篇 |
2009年 | 236篇 |
2008年 | 410篇 |
2007年 | 459篇 |
2006年 | 376篇 |
2005年 | 367篇 |
2004年 | 276篇 |
2003年 | 216篇 |
2002年 | 205篇 |
2001年 | 127篇 |
2000年 | 123篇 |
1999年 | 119篇 |
1998年 | 45篇 |
1997年 | 32篇 |
1996年 | 37篇 |
1995年 | 35篇 |
1994年 | 17篇 |
1992年 | 60篇 |
1991年 | 69篇 |
1990年 | 35篇 |
1989年 | 53篇 |
1988年 | 45篇 |
1987年 | 30篇 |
1986年 | 38篇 |
1985年 | 32篇 |
1984年 | 23篇 |
1983年 | 13篇 |
1982年 | 10篇 |
1981年 | 12篇 |
1980年 | 23篇 |
1979年 | 24篇 |
1978年 | 22篇 |
1977年 | 15篇 |
1976年 | 10篇 |
1975年 | 11篇 |
1974年 | 19篇 |
1969年 | 10篇 |
排序方式: 共有8003条查询结果,搜索用时 15 毫秒
81.
Jorge MP Madjarof C Gois Ruiz AL Fernandes AT Ferreira Rodrigues RA de Oliveira Sousa IM Foglio MA de Carvalho JE 《Journal of ethnopharmacology》2008,118(3):361-366
ETHNOPHARMACOLOGICAL RELEVANCE: Arrabidaea chica Verlot. (Bignoniaceae), popularly known as Crajiru, has been traditionally used as wound healing agent. AIM OF THE STUDY: Investigate in vitro and in vivo healing properties of Arrabidaea chica leaves extract (AC). MATERIALS AND METHODS: AC was evaluated in vitro in fibroblast growth stimulation (0.25-250 microg/mL) and collagen production stimulation (250 microg/mL) assays. Allantoin (0.25-250 microg/mL) and vitamin C (25 microg/mL) were used as controls respectively. DPPH and Folin-Ciocalteau assays were used for antioxidant evaluation, using trolox (0.25-250 microg/mL) as reference antioxidant. To study wound healing properties in rats, AC (100mg/mL, 200 microL/wound/day) was topically administered during 10 days and wound area was evaluated every day. Allantoin (100mg/mL, 200 microL/wound/day) was used as standard drug. After treatment, wound sites were removed for histopathological analysis and total collagen determination. RESULTS: AC stimulated fibroblast growth in a concentration dependent way (EC50=30 microg/mL), increased in vitro collagen production and demonstrated moderate antioxidant capacity. In vivo, AC reduced wound size in 96%, whereas saline group showed only 36% wound healing. CONCLUSION: AC efficiency seems to involve fibroblast growing stimulus and collagen synthesis both in vitro and in vivo, beyond moderate scavenging activity, corroborating Crajiru folk use. 相似文献
82.
Delmanto A Nahas-Neto J Nahas EA de Oliveira ML Fernandes CE Traiman P 《European journal of obstetrics, gynecology, and reproductive biology》2008,139(2):187-192
OBJECTIVE: The objective was to analyze the effect of raloxifene on the vaginal epithelium of postmenopausal women. STUDY DESIGN: In this non-randomized clinical trial, 80 women (mean age = 60.6 years) were prospectively studied. Forty patients received 60 mg/day of raloxifene (RG), and 40 women constituted a non-treated control group (CG), paired by age and time since menopause. The treated group consisted of patients with osteoporosis of the lumbar spine. Those with a diagnosis of infection in the lower genital tract and using hormone therapy (HT) up to 6 months prior to the study were excluded. Vaginal smears were collected at baseline and after 6 months of intervention. The vaginal maturation value (VMV) was determined, and counts of superficial, intermediate and parabasal cells were performed. Smears were analyzed by only one cytopathologist who was blinded to patient data. The t-test, Wilcoxon test, and Chi-Squared test were used in the statistical analysis. RESULTS: The study groups were homogeneous regarding age, time since menopause, parity, HT use, smoking, and body mass index. No statistically significant differences were observed in VMV median values (RG, 39.7 and 35.7; CG, 50.0 and 50.0, respectively) or in the percentage of superficial, intermediate and parabasal cells between the groups at baseline and after 6 months (p>0.05). There was no significant correlation between VMV and age, time since menopause, previous HT use, or body mass index, in either of the groups. CONCLUSION: Treatment with raloxifene for 6 months has no effect on the maturation of the vaginal epithelium in postmenopausal women with osteoporosis. 相似文献
83.
Dusse LM Carvalho Md Bragança WF Paiva SG Godoi LC Guimarães DA Fernandes AP 《European journal of obstetrics, gynecology, and reproductive biology》2007,134(1):20-23
OBJECTIVE: The aim of the present study was to compare the distribution of G1691A, G20210A and C677T mutations in pre-eclamptic Brazilian women and in matched control women with an uncomplicated normal pregnancy. STUDY DESIGN: these mutations were investigated by PCR-RFLP in 83 normal pregnancies (control group) and in 30 pre-eclamptic pregnant women (severe form). RESULTS: G1691A mutation was detected neither in the control group nor in pre-eclamsia women. G20210A mutation was detected in heterozygosis in 3 (3.61%) control subjects, but not in pre-eclampsia group. C677T mutation was detected in homozygosis in 6 (7.23%) control subjects and 2 (6.67%) pre-eclamptic women and in heterozygosis in 31 (37.3%) control subjects and 12 (40%) pre-eclamptic women. Differences in the mutation frequencies detected in the two groups were not statistically significant. CONCLUSION: No correlation was observed between pre-eclampsia and presence of G1691A, G20210A and C677T mutations in Brazilian women. 相似文献
84.
85.
Araujo Júnior E Guimarães Filho HA Saito M Pires AB Pontes AL Nardozza LM Moron AF 《Archives of gynecology and obstetrics》2007,275(2):141-144
Context
The cervical teratomas are rare, benign tumors, they are formed by the three embryonic layers, and they represent only 6%
of teratomas. The prognosis depends mainly on the size and location of the lesion, on the tumor growth rate, and on the level
of tracheal compression. Prenatal diagnosis is usually reached with the aid of a two-dimensional ultrasonography (2DUS) after
the 15th week of gestation, which shows a large heterogeneous mass in the cervical region, plus a polyhydramnios, on the Doppler
mode which also shows the vascularization of the tumor.
Case report
We report a case of cervical teratoma diagnosed on the 31st week of gestation with the aid of a 2DUS and color Doppler mode.
We focus on the main findings obtained with the three-dimensional ultrasonography in surface mode, and we highlight the importance
of this methodology for the indirect evaluation of the neonatal prognosis. 相似文献
86.
Jasna E. Deluce Luisa Cardenas Aly-Khan Lalani Saman Maleki Vareki Ricardo Fernandes 《Current oncology (Toronto, Ont.)》2022,29(7):5054
Prostate cancer remains one of the leading causes of cancer death in men worldwide. In the past decade, several new treatments for advanced prostate cancer have been approved. With a wide variety of available drugs, including cytotoxic agents, androgen receptor axis-targeted therapies, and alpha-emitting radiation therapy, identifying their optimal sequencing remains a challenge. Progress in the understanding of the biology of prostate cancer has provided an opportunity for a more refined and personalized treatment selection process. With the advancement of molecular sequencing techniques, genomic precision through the identification of potential treatment targets and predictive biomarkers has been rapidly evolving. In this review, we discussed biomarker-driven treatments for advanced prostate cancer. First, we presented predictive biomarkers for established, global standard treatments for advanced diseases, such as chemotherapy and androgen receptor axis-targeted agents. We also discussed targeted agents with recent approval for special populations, such as poly ADP ribose polymerase (PARP) inhibitors in patients with metastatic castrate-resistant prostate cancer with homologous recombination repair-deficient tumors, pembrolizumab in patients with high levels of microsatellite instability or high tumor mutational burden, and prostate-specific membrane antigen (PSMA) directed radioligand theragnostic treatment for PSMA expressing tumors. Additionally, we discussed evolving treatments, such as cancer vaccines, chimeric antigen receptor T-cells (CAR-T), Bispecific T-cell engagers (BiTEs), other targeted agents such as AKT inhibitors, and various combination treatments. In summary, advances in molecular genetics have begun to propel personalized medicine forward in the management of advanced prostate cancer, allowing for a more precise, biomarker-driven treatment selection with the goal of improving overall efficacy. 相似文献
87.
Tiago Lazzaretti Fernandes Rafaella Rogatto de Faria Maria Alice Gonzales Seth L. Sherman Sara Goldchmit Andre Fleury 《Current reviews in musculoskeletal medicine》2022,15(2):150
Purpose of ReviewThis paper presents some approaches and techniques for translating an idea or research into clinical practice, considering the innovation development process.Recent FindingsInnovative tools have been a key solution for healthcare problems, such as musculoskeletal disorders, which represent a great economic burden and are among the leading causes of disability. There has been an increase in publications on this topic, but there has been no analysis of the process of innovation development. This review describes the innovation phases for translating an idea or research into clinical practice, considering the stages of discovering the opportunity, innovation creation, project specification, technology development, and innovation launch.SummaryAn analysis of the innovation development process to translate an idea or research into clinical practice, including concepts, approaches, and techniques that shows the “why”, “how”, and “what” of innovation. 相似文献
88.
Hepatobiliary surgery is a challenging surgical subspecialty that requires highly specialized training and an adequate level of experience in order to be performed safely. As a result, minimally invasive hepatobiliary surgery has been met with slower acceptance as compared to other subspecialties, with many surgeons in the field still reluctant about the approach. On the other hand, gastric surgery is a very popular field of surgery with an extensive amount of literature especially regarding open and laparoscopic surgery but not much about the robotic approach especially for oncological disease. Recent development of the robotic platform has provided a tool able to overcome many of the limitations of conventional laparoscopic hepatobiliary surgery. Augmented dexterity enabled by the endowristed movements, software filtration of the surgeon’s movements, and high-definition three-dimensional vision provided by the stereoscopic camera, allow for steady and careful dissection of the liver hilum structures, as well as prompt and precise endosuturing in cases of intraoperative bleeding. These advantages have fostered many centers to widen the indications for minimally invasive hepatobiliary and gastric surgery, with encouraging initial results. As one of the surgical groups that has performed the largest number of robot-assisted procedures worldwide, we provide a review of the state of the art in minimally invasive robot-assisted hepatobiliary and gastric surgery. The English full-text version of this article is available at SpringerLink (under supplemental). 相似文献
89.
Borges A Borges M Fernandes J Nascimento H Sameiro-Faria M Miranda V Reis F Belo L Costa E Santos-Silva A 《Renal failure》2011,33(2):138-143
End-stage renal disease (ESRD) under hemodialyses (HD) is related with a higher propensity to infections, essentially due to T-cell lymphopenia. We postulated that HD procedure affects CD4(+) T cells, especially by inducing apoptotic death and that recombinant human erythropoietin (rhEPO) therapy may also play an important role in the modulation of the immune system in these patients. T-cell phenotype and apoptosis of HD patients and healthy controls were evaluated by flow cytometry using anticoagulated whole-blood samples. In 12 HD patients, these parameters were also analyzed before and immediately after HD procedure. HD patients showed a decrease in total circulating CD3(+) lymphocytes, especially in CD4(+) T cells (0.747 ± 0.410 vs. 0.941 ± 0.216 × 10(9)/L, p < 0.05), which could be a consequence of the higher proportion of CD3(+) and CD4(+) lymphocytes in the latest stage of apoptosis (or death) and of the higher proportion of apoptotic CD4(+) T cells observed in the patients immediately after HD procedure (2.91 ± 0.780 vs. 3.90 ± 1.96, p < 0.05). A positive and statistically significant correlation between CD3(+) and CD4(+) lymphocytes in latest stage of apoptosis (or death) with HD time was found (CD3(+): r = 0.592, p < 0.01; CD4(+): r = 0.501, p < 0.01). We also found a negative and significant correlation between weekly rhEPO doses and the number of CD4(+) T cells (r = -0.358, p < 0.05). In conclusion, HD procedure still contributes to the development of T-cell lymphopenia, at least in part, by apoptosis induction. It was also shown that rhEPO therapy is associated with the CD4(+) T-cell decline, possibly by immune modulation, eliminating atypical cells and helping to restore the CD4(+) T-cell subset. 相似文献
90.
João Carlos Silva Carlos Fernandes Jaime Rodrigues Sónia Fernandes Ana Ponte Adélia Rodrigues 《Scandinavian journal of gastroenterology》2020,55(10):1157-1162
Abstract