全文获取类型
收费全文 | 2623篇 |
免费 | 129篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 157篇 |
妇产科学 | 146篇 |
基础医学 | 204篇 |
口腔科学 | 61篇 |
临床医学 | 205篇 |
内科学 | 750篇 |
皮肤病学 | 58篇 |
神经病学 | 169篇 |
特种医学 | 128篇 |
外科学 | 445篇 |
综合类 | 28篇 |
一般理论 | 1篇 |
预防医学 | 64篇 |
眼科学 | 77篇 |
药学 | 111篇 |
中国医学 | 3篇 |
肿瘤学 | 96篇 |
出版年
2024年 | 2篇 |
2023年 | 32篇 |
2022年 | 45篇 |
2021年 | 85篇 |
2020年 | 67篇 |
2019年 | 69篇 |
2018年 | 85篇 |
2017年 | 70篇 |
2016年 | 117篇 |
2015年 | 123篇 |
2014年 | 143篇 |
2013年 | 157篇 |
2012年 | 197篇 |
2011年 | 142篇 |
2010年 | 115篇 |
2009年 | 103篇 |
2008年 | 155篇 |
2007年 | 205篇 |
2006年 | 175篇 |
2005年 | 163篇 |
2004年 | 142篇 |
2003年 | 117篇 |
2002年 | 90篇 |
2001年 | 51篇 |
2000年 | 42篇 |
1999年 | 39篇 |
1998年 | 7篇 |
1997年 | 4篇 |
1996年 | 6篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有2768条查询结果,搜索用时 0 毫秒
21.
22.
23.
Cancer is a major worldwide health problem and one of the leading causes of death either in developed or developing countries. Plant extracts and derivatives have always been used for various disease treatments and many anticancer agents issued from plants and vegetables are clinically recognized and used all over the world. Lycium europaeum (Solanaceae) also called “wolfberry” was known since ancient times in the Mediterranean area as a medicinal plant and used in several traditional remedies. The Lycium species capacity of reducing the incidence of cancer and also of halting or reserving the growth of cancer was reported by traditional healers. In this study, the antiproliferative capacity, protective properties, and antioxidant activity of the hydro-alcoholic fruit extract of Lycium europaeum were investigated. Results showed that Lycium extract exhibits the ability to reduce cancer cell viability, inhibits proliferation, and induces apoptosis in A549 human lung cancer cells and PC12 rat adrenal medulla cancer cells, in a concentration- and time-dependent manner. Cytotoxic effect on normal rat cerebellum granule cells was assessed to be nonsignificant. Results also showed that Lycium fruit extract protected lipids, proteins, and DNA against oxidative stress damages induced by H2O2 via scavenging reactive oxygen species. 相似文献
24.
Woven coronary artery is an extremely rare and not clearly defined congenital malformation in which the epicardial coronary artery is divided into multiple thin channels. These multiple channels merge again into a normal conduit. This anomaly is a benign condition because there is normal blood flow after the anomalous segment of the abnormal coronary artery. We describe a woven coronary artery anomaly in the left anterior descending artery (LAD) and its first diagonal (DI) branch causing myocardial infarction that was confused with coronary dissection. The definitive diagnosis was made by optical coherence tomography (OCT). Although woven coronary is a benign anomaly, it may cause myocardial infarction. We used the novel method of OCT for the definitive diagnosis and appropriate treatment of this anomaly. 相似文献
25.
26.
27.
Factor V Leiden mutation and other thrombophilia markers in childhood ischemic stroke. 总被引:4,自引:0,他引:4
Ridvan Duran Betül Biner Muzaffer Demir Co?kun Celtik Serap Karasaliho?lu 《Clinical and applied thrombosis/hemostasis》2005,11(1):83-88
The aim of this study was to evaluate the association between ischemic childhood stroke and thrombophilia. The prevalence of thrombophilia risk factors in 30 unrelated children with ischemic stroke were compared with 33 age-matched control subjects. Patients and control group were tested for the presence of activated protein C (APC) resistance, antiphospholipid antibodies (APLA), increased factor VIII levels, and for the deficiency of protein C (PC), protein S (PS), and antithrombin. When APCR was detected in patients or in controls, factor V Leiden (FVL) mutation was also tested. Seventeen of 30 patients (56.6%) had at least one thrombophilia marker compared with only 5 of 33 control subjects (15.1%). Three children with ischemic stroke (10%) were affected with a combination of two or more thrombophilia markers whereas none of the children in the control group had a combination of risk factors. Seven of 30 children with ischemic stroke (23.3%) and one of 33 control subjects (3.03%) had APC resistance and in all of them FVL mutation were found. The prevalence of FVL mutation was higher among pediatric stroke patients than among control subjects (p < 0.05). None of the patients but one child from the control group (3.03%) had PS deficiency. Antithrombin and PC deficiencies and the presence of APLA and increased factor VIII levels were more frequent in the pediatric stroke patients than in controls but the difference was not statistically significant (p > 0.05). These data confirm that stroke in children is commonly associated with a combination of multiple risk factors and especially the prevalence of FVL mutation is increased in children with ischemic stroke compared with control subjects. 相似文献
28.
Nedim Durmus Sefa Gültürk Tijen Kaya Tuncer Demir Mesut Parlak Ahmet Altun 《Indian journal of pharmacology》2015,47(1):34-38
Objectives:It is suggested that excessive calcium entry into neurons is the main triggering event in the initiation of epileptic discharges. We aimed to investigate the role of T and N type calcium channels in absence epilepsy experimental model.Results:Beta and delta recording ratios in 1 μM/5 μl mibefradil group was significantly different from basal and other dose-injected groups. Beta, alpha, and theta recordings in 0.2 μM/5 μl w-Conotoxin MVIIA group was significantly different from basal and other dose-injected groups. In w-Conotoxin MVIIA after mibefradil group, beta, alpha, and theta recording ratios were significantly different from basal and mibefradil group. Mibefradil and w-Conotoxin MVIIA significantly decreased the frequency and duration of SWDs. The decrease of frequency and duration of SWDs in mibefradil group was significantly different from w-Conotoxin MVIIA group. The frequency and duration of SWDs significantly decreased in w-Conotoxin MVIIA after mibefradil group compared with basal, mibefradil, and w-Conotoxin MVIIA groups.Conclusions:We concluded that both T and L type calcium channels play activator roles in SWDs and have positive effects on frequency and duration of these discharges. These results are related with their central effects more than peripheral effects.KEY WORDS: Epilepsy, mibefradil, T and N type calcium channels, Wistar Albino Glaxo/Rij rats, w-Conotoxin MVIIA 相似文献
29.
Demir Arzu Meltem Aydin Fatma Acar Banu Kurt Tuba Poyraz Aylar Kiremitci Saba Gülleroglu Basak Azili Müjdem Nur Bayrakci Umut Selda 《Clinical rheumatology》2021,40(9):3817-3825
Clinical Rheumatology - Autoimmune pancreatitis (AIP) type 1 is an IgG4-related disease (IgG4-RD), characterized by inflammatory pseudotumors and histologically by dense lymphoplasmacytic... 相似文献
30.
Cebi Alper Han Demir Ferhat Ikbal Mevlit Kalyoncu Mukaddes 《Clinical rheumatology》2021,40(5):1975-1981
Clinical Rheumatology - Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal... 相似文献