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91.
The increasing frequency and complexity of medical radiation exposures to humans inevitably result in higher risks of harmful unintended or accidental radiation exposures. To ensure a high level of protection and its continuous improvement, the Directive 2013/59/Euratom thus requires to systematically record and analyze both events and near-miss events as well as, in the case of their significance, to disseminate information regarding lessons learned from these events promptly and nationwide to improve radiation protection in medicine. These requirements have been transposed into German legislation by the new radiation protection law and radiation protection ordinance that entered into force simultaneously on December 31th, 2018. The reporting and information system as provided by these regulations as well as the tasks, duties and powers of the parties involved are presented in the first part of this review article. In the second part, the established application-specified criteria for the significance – and thus the notification requirement - of (near-miss) events are itemized and explicated. 相似文献
92.
Gunnar E. Carlsson Byron Ch. Droukas 《Cranio : the journal of craniomandibular practice》2013,31(2):141-147
The purpose of this article is to review recent dental literature dealing with the association between occlusal factors and functional disturbances of the masticatory system. There has been much controversy among various authors about the role of occlusion in mandibular dysfunction.Studies on the number of teeth and the state of the dentition have shown no distinct patterns in patients with mandibular dysfunction. This can probably be explained by the existence of a wide range of individual adaptability to occlusal conditions. In most studies only weak correlations, if any, have been found between occlusal interferences and mandibular dysfunction. This article reviews clinical, electromyographic, experimental, and epidemiologic studies for such possible consequences.The findings of our study lend support to the idea that the etiology of mandibular dysfunction is multifactorial. Occlusal factors generally seem to be of minor importance. It is thus probable that extensive occlusal rehabilitation is not necessary, at least in the initial phase, for treatment of mandibular dysfunction. 相似文献
93.
Gunnar Baatrup Niels Qvist 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2014,122(8):715-722
The introduction of the National Danish screening programme for colorectal cancer will result in the detection of more early rectal cancers (ERC), which may be considered for local excision. For the low risk ≤T1 cancer, the oncological outcome at local excision in smaller patient series has shown similar results to conventional surgery, but with a significantly lower rate of serious complications, morbidity and mortality. The challenge is correct preoperative staging, and a meticulous systematic histopathological staging of the excised specimen to distinguish the low risk from high‐risk cases, where rescue surgery may be considered. The establishment of a regional or national clinical database is necessary to improve the local treatment of ERC. 相似文献
94.
95.
Tomas Magnusson Inger Egermark-Eriksson Gunnar E. Carlsson 《Cranio : the journal of craniomandibular practice》2013,31(4):338-344
A longitudinal study covering five years of clinical signs and subjective symptoms of mandibular dysfunction was performed in 119 adolescents, 15 years old at the first examination and 20 years old at the follow-up. Sixty-two percent had clinical signs of mandibular dysfunction, but the signs were in most cases mild, while moderate and severe signs were found in 17%. No change in clinical signs between the two examinations were noted in nearly half of the individuals, and improvement and impairment had occurred at an almost equal rate.At the follow-up, 31% of the participants reported that they sometimes had TMJ sound, tiredness in the jaws, or difficulties in mouth opening, and another 8% suffered from one or more of these symptoms frequently. The frequency of subjective symptoms as well as reports of bruxism had increased statistically significantly compared with five years previously.A statistically significant correlation was found between the subjective symptoms and the clinical dysfunction index used. No single subjective or clinical variable or combination of variables seemed to have any significant influence on the positive or negative changes of the clinical dysfunction index between the two examinations. The explanation suggested is that the development of clinical signs of mandibular dysfunction is very complex, including numerous variables, some of which were not recorded in the present investigation. 相似文献
96.
Jawad H. Butt Nikolaj Ihlemann Ole De Backer Lars Søndergaard Eva Havers-Borgersen Gunnar H. Gislason Christian Torp-Pedersen Lars Køber Emil L. Fosbøl 《Journal of the American College of Cardiology》2019,73(13):1646-1655
Background
Patients undergoing surgical aortic valve replacement (SAVR) are considered at high risk of infective endocarditis (IE). However, data on the risk of IE following transcatheter aortic valve replacement (TAVR) are sparse and limited by the lack of long-term follow-up as well as a direct comparison with patients undergoing SAVR.Objectives
This study sought to investigate the long-term incidence of IE in patients undergoing TAVR and to compare the long-term risk of IE with patients undergoing isolated SAVR.Methods
In this nationwide observational cohort study, all patients undergoing TAVR and isolated SAVR from January 1, 2008, to December 31, 2016, with no history of IE and alive at discharge were identified using data from Danish nationwide registries.Results
A total of 2,632 patients undergoing TAVR and 3,777 patients undergoing isolated SAVR were identified. During a mean follow-up of 3.6 years, 115 patients (4.4%) with TAVR and 186 patients (4.9%) with SAVR were admitted with IE. The median time from procedure to IE hospitalization was 352 days (25th to 75th percentile: 133 to 778 days) in the TAVR group and 625 days (25th to 75th percentile: 209 to 1,385 days) in the SAVR group. The crude incidence rates of IE were 1.6 (95% confidence interval [CI]: 1.4 to 1.9) and 1.2 (95% CI: 1.0 to 1.4) events per 100 person-years in TAVR and SAVR patients, respectively. The cumulative 1-year risk of IE was 2.3% (95% CI: 1.8% to 2.9%) and 1.8% (95% CI: 1.4% to 2.3%) in TAVR and SAVR patients, respectively. Correspondingly, the cumulative 5-year risk of IE was 5.8% (95% CI: 4.7% to 7.0%) and 5.1% (95% CI: 4.4% to 6.0%), respectively. In multivariable Cox proportional hazard analysis, TAVR was not associated with a statistically significant different risk of IE compared with SAVR (hazard ratio: 1.12; 95% CI: 0.84 to 1.49).Conclusions
The 5-year incidence of IE following TAVR was 5.8% and not significantly different than the incidence following SAVR. 相似文献97.
98.
Per Wiger Gunnar Blomqvist Jorma Styf 《Journal of plastic surgery and hand surgery》2013,47(4):315-320
Intramuscular pressure (IMP) was measured in 16 patients during secondary wound closure by dermatotraction with external tissue extension (ETE®). Secondary wound closure was done 4-16 days after fasciotomy for acute compartment syndrome. The traction between wound edges was 2.5 N in the first six patients and 3.5 N in the following 10 patients. Mean (SD) IMP was 6.9 (3.5) mmHg before wound closure. It increased to 12.3 (1.4) mmHg in the 2.5 N group and to 24.7 (7.0) mmHg in the 3.5 N group when dermatotraction was applied. Mean (SD) leg perfusion pressure in the 2.5 N group decreased by 7% to 69.3 (10.9) mmHg and in the 3.5 N group by 23% to 62.2 (7.4) mmHg. None of the patients needed a skin graft. We conclude that dermatotraction by ETE® raises IMP intraoperatively sufficiently to preserve adequate limb perfusion pressures. 相似文献
99.
100.
Josephine Prener Holtan Knut Teigen Ingvild Aukrust Ragnheiður Bragadóttir Gunnar Houge 《Ophthalmic genetics》2019,40(2):124-128
Purpose: To clinically and genetically characterise a second family with dominant ARL3-related retinitis pigmentosa due to a specific ARL3 missense variant, p.(Tyr90Cys).Methods: Clinical examination included optical coherence tomography, electroretinography, and ultra-wide field retinal imaging with autofluorescence. Retrospective data were collected from the registry of inherited retinal diseases at Oslo university hospital. DNA was analysed by whole-exome sequencing and Sanger sequencing. The ARL3 missense variant was visualized in a 3D-protein structure.Results: The phenotype was non-syndromic retinitis pigmentosa with cataract associated with early onset of decreased central vision and central retinal thinning. Sanger sequencing confirmed the presence of a de novo ARL3 missense variant p.(Tyr90Cys) in the index patient and his affected son. We did not find any other cases with rare ARL3 variants in a cohort of 431 patients with retinitis pigmentosa-like disease. By visualizing Tyr90 in the 3D protein structure, it seems to play an important role in packing of the α/β structure of ADP-ribosylation factor-like 3 (ARL3). When changing Tyr90 to cysteine, we observe a loss of interactions in the core of the α/β structure that is likely to affect folding and stability of ARL3.Conclusion: Our study confirms that the ARL3 missense variant p.(Tyr90Cys) causes retinitis pigmentosa. In 2016, Strom et al. reported the exact same variant in a mother and two children with RP, labelled ?RP83 in the OMIM database. Now the questionmark can be removed, and ARL3 should be added to the list of genes that may cause non-syndromic dominant retinitis pigmentosa. 相似文献