全文获取类型
收费全文 | 213篇 |
免费 | 16篇 |
国内免费 | 3篇 |
专业分类
儿科学 | 8篇 |
妇产科学 | 3篇 |
基础医学 | 22篇 |
口腔科学 | 3篇 |
临床医学 | 25篇 |
内科学 | 60篇 |
皮肤病学 | 5篇 |
神经病学 | 7篇 |
特种医学 | 4篇 |
外科学 | 52篇 |
预防医学 | 9篇 |
眼科学 | 1篇 |
药学 | 9篇 |
肿瘤学 | 24篇 |
出版年
2021年 | 3篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 1篇 |
2014年 | 7篇 |
2013年 | 5篇 |
2012年 | 10篇 |
2011年 | 15篇 |
2010年 | 8篇 |
2009年 | 10篇 |
2008年 | 11篇 |
2007年 | 11篇 |
2006年 | 26篇 |
2005年 | 14篇 |
2004年 | 13篇 |
2003年 | 16篇 |
2002年 | 17篇 |
2001年 | 4篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1905年 | 1篇 |
1904年 | 1篇 |
排序方式: 共有232条查询结果,搜索用时 15 毫秒
231.
Testa L Bhindi R Agostoni P Abbate A Zoccai GG van Gaal WJ 《Expert opinion on drug safety》2007,6(4):397-406
The direct thrombin inhibitor, ximelagatran, and its active form, melagatran (X/M), have been compared against conventional anticoagulant therapy (CAT) in many clinical settings. Their risk-benefit profile drove large debate until withdrawal by the manufacturer. A systematic review of all published randomized trials has been performed and a meta-analysis of randomised controlled trial (RCT) of X/M versus CAT. Major medical databases were searched for RCTs. Major adverse events (MAE: all cause death, nonfatal myocardial infarction, nonfatal thromboembolic stroke, pulmonary embolism), major bleeds (MB), minor bleeds and the rate of hepatotoxicity (HT) were compared. In terms of efficacy, X/M was at least as effective as, or even superior to, CAT. In terms of safety, the overall risk of MAE, MB, minor bleeds and HT was not significantly different for X/M compared with CAT. According to individual clinical settings, X/M was associated with a lower risk of MB but a prohibitive higher risk of HT in those clinical settings requiring prolonged treatment. 相似文献
232.
Doulton TW Saggar-Malik AK He FJ Carney C Markandu ND Sagnella GA MacGregor GA 《Journal of hypertension》2006,24(5):939-945
BACKGROUND: It has been suggested that inappropriate stimulation of the renin-angiotensin system (RAS) is responsible for the increase in blood pressure that occurs in autosomal-dominant polycystic kidney disease (ADPKD) before the development of renal failure. However, the interpretation of previous studies in ADPKD patients is confounded by inadequate matching with control populations for blood pressure and renal function, or failure to control the sodium intake of participants. METHODS: A double-blind, placebo-controlled study of two different sodium intakes (350 and 50 mmol/day for 5 days) in a group of 11 hypertensive ADPKD patients and eight matched control subjects with essential hypertension. In addition, blood pressure and hormonal responses were measured after the administration of the angiotensin-converting enzyme inhibitor enalapril for 3 days. RESULTS: Blood pressure and hormonal responses of the RAS after a reduction in sodium intake and after the administration of enalapril were identical in ADPKD patients and controls. CONCLUSIONS: Activation of the classic circulating RAS is no greater in hypertensive ADPKD patients than in individuals with essential hypertension. 相似文献