全文获取类型
收费全文 | 1429篇 |
免费 | 131篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 52篇 |
妇产科学 | 26篇 |
基础医学 | 322篇 |
口腔科学 | 8篇 |
临床医学 | 137篇 |
内科学 | 320篇 |
皮肤病学 | 36篇 |
神经病学 | 160篇 |
特种医学 | 34篇 |
外科学 | 141篇 |
综合类 | 2篇 |
预防医学 | 99篇 |
眼科学 | 9篇 |
药学 | 85篇 |
中国医学 | 11篇 |
肿瘤学 | 115篇 |
出版年
2024年 | 2篇 |
2023年 | 11篇 |
2022年 | 19篇 |
2021年 | 25篇 |
2020年 | 17篇 |
2019年 | 35篇 |
2018年 | 27篇 |
2017年 | 25篇 |
2016年 | 25篇 |
2015年 | 48篇 |
2014年 | 64篇 |
2013年 | 58篇 |
2012年 | 132篇 |
2011年 | 95篇 |
2010年 | 74篇 |
2009年 | 59篇 |
2008年 | 95篇 |
2007年 | 93篇 |
2006年 | 93篇 |
2005年 | 103篇 |
2004年 | 106篇 |
2003年 | 94篇 |
2002年 | 75篇 |
2001年 | 11篇 |
2000年 | 9篇 |
1999年 | 11篇 |
1998年 | 23篇 |
1997年 | 20篇 |
1996年 | 17篇 |
1995年 | 10篇 |
1994年 | 17篇 |
1993年 | 16篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1978年 | 5篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有1566条查询结果,搜索用时 0 毫秒
71.
Martin S Lĵo H Peuskens J Thirumalai S Giudicelli A Fleurot O Rein W;SOLIANOL Study Group 《Current medical research and opinion》2002,18(6):355-362
OBJECTIVE: To compare the efficacy and safety of the atypical antipsychotics amisulpride and olanzapine in the treatment of acute psychotic exacerbations of schizophrenia. DESIGN AND SETTING: A multinational, double-blind randomised clinical trial. PATIENTS AND TREATMENT: Three hundred and seventy-seven patients with predominantly positive symptomatology were treated for six months with either amisulpride (200-800 mg/d) or olanzapine (5-20 mg/d). MAIN OUTCOME MEASURES: Short-term results were analysed after two months of treatment. The primary efficacy measure was the change of score on the Brief Psychiatric Rating Scale (BPRS). Other measures of efficacy and safety were also evaluated. RESULTS: Psychotic symptoms, as measured on the BPRS score, improved with both treatments, amisulpride being equivalent to olanzapine. All BPRS factor scores, as well as depressive symptoms, improved to a similar extent with both treatments. Less than five per cent of patients withdrew for adverse events, and there was no evidence for the emergence of extrapyramidal symptoms with either treatment. Statistically significant greater weight gain (2.7 +/- 3.9 kg) was observed during the study in the olanzapine group, compared with the amisulpride group (0.9 +/- 3.2 kg, p < 0.0001). CONCLUSIONS: Amisulpride and olanzapine show equivalent efficacy at 2 months in the treatment of acute psychotic exacerbations of schizophrenia. Amisulpride offers a significant advantage in preserving body weight. 相似文献
72.
Brouri F Findji L Mediani O Mougenot N Hanoun N Le Naour G Hamon M Lechat P 《European journal of pharmacology》2002,439(1-3):69-75
This study investigates the effect of microinjections of capsaicin in the periaqueductal grey matter of rats on nociceptive behaviour and the possible interactions with NMDA and mGlu receptors. Intra-periaqueductal grey microinjection of capsaicin (1-3-6 nmol/rat) increased the latency of the nociceptive reaction in the plantar test. This effect was prevented by pretreatment with capsazepine (6 nmol/rat), which had no effect per se on the latency of the nociceptive reaction. 7-(Hydroxyimino)cyclopropa[b]chromen-1alpha-carboxylate ethyl ester (CPCCOEt, 50 nmol/rat) and 2-Methyl-6-(phenylethynyl)pyridine (MPEP, 50 nmol/rat), antagonists of mGlu(1) and mGlu(5) receptors, respectively, completely blocked the effect of capsaicin. Similarly, pretreatment with DL-2-Amino-5-phosphonovaleric acid (DL-AP5, 5 nmol/rat) and riluzole (4 nmol/rat), an NMDA receptor antagonist and a voltage-dependent Na(+) channels blocker which inhibits glutamate release, respectively, completely antagonized the effect of capsaicin. However, pretreatment with (2S)-alpha-Ethylglutamic acid (30 nmol/rat) and (RS)-alpha-Methylserine-O-phosphate (MSOP, 30 nmol/rat), antagonists of group II and group III mGlu receptors, respectively, had no effects on capsaicin-induced analgesia. Similarly, pretreatment with N-(piperidin-1-yl)-5-(4-chlophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR 141716A, 5 pmol/rat), a selective cannabinoid CB(1) receptor antagonist, did not affect the capsaicin-induced antinociception. In conclusion, this study shows that capsaicin might produce antinociception at the periaqueductal grey level by increasing glutamate release, which activates postsynaptic group I mGlu and NMDA receptors. 相似文献
73.
Suzan F Guasch G Terre C Garcia I Bastie JN Maarek O Ribaud P Gluckman E Daniel MT Pébusque MJ Castaigne S 《British journal of haematology》2003,121(2):312-314
A rare atypical myeloproliferative disorder (aMPD) associated with chromosomal translocations involving the short arm of chromosome 8, region p11-p12 has been described. In most patients, the cytogenetic abnormality is a t(8;13)(p12;q12) that fuses fibroblast growth factor receptor 1, the 8p12 key gene, to FIM/ZNF198 gene. Prognosis is poor with frequent evolution to acute myeloid leukaemia within 1 year of diagnosis. We report a new patient with aMPD with a t(8;13) translocation. Complete haematological, cytogenetic and molecular remission was demonstrated 39 months after allogeneic bone marrow transplantation. This is the first report to demonstrate a molecular remission in this disorder. 相似文献
74.
Birouk N Azzedine H Dubourg O Muriel MP Benomar A Hamadouche T Maisonobe T Ouazzani R Brice A Yahyaoui M Chkili T Le Guern E 《Archives of neurology》2003,60(4):598-604
BACKGROUND: The first locus for demyelinating autosomal recessive Charcot-Marie-Tooth (ARCMT) disease was identified in 8q13, where mutations in GDAP1 have been found. Mutations in the same gene have been detected in families with axonal ARCMT disease. OBJECTIVE: To determine the clinical, electrophysiologic, and morphologic characteristics of a consanguineous Moroccan family with ARCMT disease associated with the S194X mutation in the GDAP1 gene. METHODS: Four patients from a consanguineous Moroccan family were examined clinically and electrophysiologically. In one patient, a morphometric and ultrastructural study of a peroneal nerve biopsy sample was performed. Mutation in the coding region of the GDAP1 gene was identified by direct sequencing. RESULTS: Neuropathy was evident early in childhood, walking was delayed in one patient, and onset of symptoms occurred before 18 months in the others. The phenotype was severe: foot deformities and disabilities involving the hands and feet developed toward the end of the first decade, followed by involvement of proximal muscles in the lower limbs, leading to loss of autonomy. Electrophysiologic findings were consistent with an axonal form of CMT disease: motor nerve conduction velocities, recordable in one patient only, were greater than 40 m/sec. Sensory nerve action potentials were either abolished or substantially reduced in amplitude. The morphologic data supported the diagnosis of axonal neuropathy, showing a marked reduction in myelinated fibers and signs of axonal regeneration, including frequent pseudo-onion bulb formations. The 4 patients in this family were homozygous for the S194X mutation in the GDAP1 gene. CONCLUSION: Electrophysiologic and pathological findings support the hypothesis of an axonal disorder in this ARCMT family with the S194X mutation in the GDAP1 gene. 相似文献
75.
The concept of major functional resistance to O2 flux at the capillary-fiber interface implies that muscle structural capacity for O2 flux from capillary to fiber mitochondria needs to be assessed in terms of capillary surface per fiber surface. Morphological data support this notion and show the importance of assessing the size of the capillary-fiber interface relative to muscle fiber O2 demand. 相似文献
76.
Camila Giugliani Gwenaelle Vidal-Trecan Souleymane Traore Herve Blanchard Gabriela Spiridon Florence Rollot Odile Launay Myriam Gorodestski Jean-Luc Marande Christophe Vinsonneau Loic Guillevin Dominique Salmon-Ceron 《Infection control and hospital epidemiology》2006,27(6):626-629
The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen. 相似文献
77.
Aspergillus galactomannan detection in the diagnosis of invasive aspergillosis in cancer patients. 总被引:9,自引:0,他引:9
Raoul Herbrecht Valérie Letscher-Bru Corina Oprea Bruno Lioure Jocelyn Waller France Campos Odile Villard Kun-Lun Liu Shanti Natarajan-Amé Patrick Lutz Patrick Dufour Jean-Pierre Bergerat Ermanno Candolfi 《Journal of clinical oncology》2002,20(7):1898-1906
PURPOSE: To assess the Aspergillus galactomannan enzyme-linked immunosorbent assay (ELISA) in the diagnosis of invasive aspergillosis (IA) in adult and pediatric oncohematologic patients. PATIENTS AND METHODS: The study was conducted in four patient groups: those with fever of unknown origin (FUO) during neutropenia, suspected pulmonary infection (PI), or nonpulmonary aspergillosis (NPA) and those undergoing surveillance (S) after hematopoietic stem-cell transplantation (HSCT). IA was classified as definite, probable, or possible, according to European Organization for Research and Treatment of Cancer/Mycosis Study Group definitions. RESULTS: A total of 3,294 serum samples were collected during 797 episodes (FUO, 261; PI, 297; NPA, 28; and surveillance, 211), and 153 episodes of IA were diagnosed (31 definite, 67 probable, and 55 possible). Three episodes were first suspected from galactomannan ELISA; the remaining 150 cases were diagnosed from clinical or radiologic evidence. Sensitivity of the ELISA was 64.5%, 16.4%, and 25.5% in definite, probable, and possible episodes of IA, respectively, and was lower in patients positive for anti-Aspergillus antibodies than in antibody-negative patients. Most false-positive results occurred in children and in allogeneic HSCT (allo-HSCT) patients. Overall specificity of the ELISA was 94.8%. It was lower in children compared with adults (P <.0001) and in allo-HSCT patients compared with non-allo-HSCT adults (P =.0002). Lowering the ELISA cutoff value from 1.500 to 0.700 seemed more relevant for non-allo-HSCT adults (sensitivity, 73.1%, 44.3%, and 44.7% in definite, probable, and possible IA, respectively; specificity, 94%). CONCLUSION: Galactomannan ELISA seems less sensitive than previously described, and sensitivity can be further reduced by the presence of anti-Aspergillus antibodies. A new cutoff value for the ELISA of 0.700 is proposed for non-allo-HSCT adults. 相似文献
78.
79.
Rogier C Pradines B Bogreau H Koeck JL Kamil MA Mercereau-Puijalon O 《Emerging infectious diseases》2005,11(2):317-321
Analysis of Plasmodium falciparum isolates collected before, during, and after a 1999 malaria epidemic in Djibouti shows that, despite a high prevalence of resistance to chloroquine, the epidemic cannot be attributed to a sudden increase in drug resistance of local parasite populations. 相似文献
80.
Gonadotropins and progesterone induce in vitro meiotic maturation of the follicleenclosed Xenopus laevis oocyte. The kinetics of maturation are identical for both hormones. The enzymatic removal of the follicular envelopes which suppresses gonadotropin activity does not modify the efficiency of progesterone (1 μM)-induced maturation. It was, however, shown that defolliculation decreases the kinetic of maturation: GVBD50 (the time necessary to obtain 50% of germinal vesicle breakdown or maturation) was 8.08 ± 1.25 hr when follicles are induced to mature in the presence of progesterone and 4.30 ± 0.89 hr in the case of defolliculated oocytes. This result demonstrates that the follicular envelopes play a role in inhibition of steroid-induced maturation. When oocytes are defolliculated in the presence of aminogluthetimide, an inhibitor of steroid synthesis, the kinetic of oocyte maturation is also decreased (GVBD50: 4.98 ± 1.75 hr) indicating that the biosynthesis of steroid at the level of follicular envelopes is not involved in the phenomenon. 相似文献