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BACKGROUND Pharmacologic augmentation to mimic the delay phenomenon that increases skin flap survival has been studied extensively. Tadalafil is a phosphodiesterase V inhibitor that is used for treatment of erectile dysfunction by enhancing vascular smooth muscle relaxation.
OBJECTIVE The aim of this study was to investigate the effects of local injection of tadalafil in enhancing axial-pattern skin flap survival in rats.
MATERIALS AND METHODS Twenty Sprague-Dawley rats were used and a McFarlane-type caudally based axial-pattern skin flap was designed on the dorsum of the rat (2 × 9 cm). Rats were divided into two groups: the treatment group and the control group. Tadalafil 10 mg/kg/day was injected to the distal flap area of the treatment group for 3 days, and normal saline was injected for the control group. On Postoperative Day 7, necrotic flap area was measured and compared, and angiograms of the skin flaps were obtained in the two groups.
RESULTS In the treatment group, the mean necrotic area was 21.9±6.4%, and in the control group, 37.7±5.9%. There was a statistically significant increase of skin flap survival in the treatment group ( p =.001). Angiography also showed vasodilation of the choke vessels between adjacent angiosomes to form true anastomosis in the treatment group.
CONCLUSION The results demonstrate that the use of local injection of tadalafil to failing skin flaps increases the survival of axial-pattern flaps in rats. 相似文献
OBJECTIVE The aim of this study was to investigate the effects of local injection of tadalafil in enhancing axial-pattern skin flap survival in rats.
MATERIALS AND METHODS Twenty Sprague-Dawley rats were used and a McFarlane-type caudally based axial-pattern skin flap was designed on the dorsum of the rat (2 × 9 cm). Rats were divided into two groups: the treatment group and the control group. Tadalafil 10 mg/kg/day was injected to the distal flap area of the treatment group for 3 days, and normal saline was injected for the control group. On Postoperative Day 7, necrotic flap area was measured and compared, and angiograms of the skin flaps were obtained in the two groups.
RESULTS In the treatment group, the mean necrotic area was 21.9±6.4%, and in the control group, 37.7±5.9%. There was a statistically significant increase of skin flap survival in the treatment group ( p =.001). Angiography also showed vasodilation of the choke vessels between adjacent angiosomes to form true anastomosis in the treatment group.
CONCLUSION The results demonstrate that the use of local injection of tadalafil to failing skin flaps increases the survival of axial-pattern flaps in rats. 相似文献
64.
A-M Bisgaard Pedersen K Kok G Petersen OH Nielsen KF Michaelsen K Schmiegelow 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(8):849-852
We reviewed the clinical course of 32 children with cancer who received nutrition through a feeding tube placed percutaneously during gastroscopy (PEG). Their median age was 5.1 y (75%, range: 1.8-13.7 y, min: 3.5 mo) when the PEG was done 0.7-23 mo after diagnosis (median: 1.8 mo, 75%; range: 0.9-8 mo). Five of the children underwent bone marrow transplantation with the gastrostomy in place. There was a significant (p 相似文献
65.
Oettel KR; Wesly OH; Albertini MR; Hank JA; Iliopolis O; Sosman JA; Voelkerding K; Wu SQ; Clark SS; Sondel PM 《Blood》1994,83(11):3390-3402
Immunocompetent cells in bone marrow allografts have been associated with a graft-versus-leukemia (GVL) effect. To further characterize effector mechanisms that may be involved in this GVL phenomenon, we have previously established an in vitro model to identify allogeneic T- cell clones that selectively mediate cytotoxicity against a patient's leukemic cells, but not against nonleukemic lymphocytes from the same patient. We have modified this in vitro model to test whether the Ph1 chromosome and the P210 fusion protein it controls have a detectable role in leukemia-specific recognition by allogeneic T-cell clones. In this report, T-cell lines reactive with allogeneic Ph1 chromosome- bearing (Ph1+) chronic myeloid leukemia (CML) cell lines were derived and selected to be minimally reactive with Ph1 negative (Ph1-) lymphoid lines from the same patient. However, after prolonged culture, these same T-cell lines also mediated significant destruction of the Ph1- target cells from the same patients. These T-cell lines specifically recognized cells from the allogeneic CML patient to which they were sensitized, and were not contaminated by an outgrowth of natural killer cells. Furthermore, subclones could be derived from these T-cell lines, and some of these subclones again showed selective killing of the allogeneic Ph1+ leukemia cell lines, and not of the Ph1- cell line from the same patient. Analyses of T-cell receptor (TCR) genes showed the alloreactive T-cell lines and the Ph1+ selective subclones derived from them to be of the same clonal origin. This suggests that the same T cells reacting with antigens expressed on the nonleukemic Ph1- targets can at times selectively and preferentially kill the allogeneic Ph1+ cells. As the same TCR that recognizes Ph1+ cells also can recognize the Ph1- targets, it appears that the Ph1+ chromosome does not play a detectable role in recognition by these allogeneic T-cell clones. This in vitro observation may provide a model for evaluating the relationship between GVL and graft-versus-host disease effects. 相似文献
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Hwan-Cheol KIM Dirga Kumar LAMICHHANE Dal-Young JUNG Hyoung-Ryoul KIM Eun-Hee CHOI Sung-Soo OH Hee-Tae KANG Kyung-Yong RHEE Sei-Jin CHANG 《Industrial health》2015,53(5):445-453
This study was conducted to investigate the relationship of active and passive smoking
with occupational injury among manual workers. Data from the 2011 Korean Working
Conditions Survey were analyzed for 12,507 manual workers aged ≥15 yr. Overall, 60.4% of
men and 5.8% of women were current smokers. The prevalence of injury was higher among
never smokers who were exposed to secondhand smoke (SHS) (7.7% in men and 8.1% in women)
than current smokers (4.2% in men and 4.1% in women). After controlling for potential
confounders, in men, compared to those who never smoked and were not exposed to SHS,
people who never smoked and were exposed to SHS (adjusted odds ratio (aOR)=3.7, 2.2–6.4)
and current smokers (aOR=2.5, 1.6–3.8) were more likely to experience injury. Among women,
the aORs of occupational injury were 8.4 (4.2–16.7) for never smoking women with
occasional exposure to SHS and 3.5 (95% CI: 1.4–8.7) for current smokers, in comparison to
never smoking women who were never exposed to SHS at work (reference group). The present
study suggests that exposure to SHS is a possible risk factor of occupational injury for
never smoking men and women. 相似文献
69.
Background
Hospitalization for eye care is required for different reasons. The pattern of admissions into the ophthalmic wards of a sub-urban tertiary hospital was studied.Methodology
Records of patients admitted into the Ophthalmology wards of the Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife from January 2004 to December 2007 were reviewed and the age, sex, duration of admission and diagnosis recorded. Data was analyzed with SPSS version 13 and statistical significance inferred at P<0.05.Results
Of the 523 patients admitted, 60.2% were males while 39.8% were females (P<0.0001); the male preponderance becomes less prominent with increasing age (P=0.001). The duration of admission ranged between 2 and 24 days with a mean of 2.86± 1.95 days and 63% were admitted for 3 days. The main indications for admission were cataract (58.3%), ocular trauma (14.3%) and glaucoma (13.4%). Eye injuries were more common among children and young adults while cataract and glaucoma were the leading indications in the middle aged and elderly.Conclusion
Cataract, trauma and glaucoma were the leading indications for ophthalmic hospitalization. Human and infrastructural development of the ophthalmology unit should lay emphasis on the more prevalent needs to enhance effective and efficient management of these diseases. 相似文献70.
BYEONG-KEUK KIM M.D. Ph .D. SEUNGJIN OH M.D. DONG WOON JEON M.D. JOO YOUNG YANG M.D. Ph .D. JUNG-SUN KIM M.D. Ph .D. SUNGHA PARK M.D. Ph .D. DONGHOON CHOI M.D. Ph .D. YANGSOO JANG M.D. Ph .D. BUM-KEE HONG M.D. Ph .D. HYUK MOON KWON M.D. Ph .D. SEUNG-WHAN LEE M.D. Ph .D. CHOONG WON GOH M.D. Ph .D. KIHWAN KWON M.D. Ph .D. SUNG KEE RYU M.D. for the Korean Multicenter Angioplasty Team Investigators 《Journal of interventional cardiology》2009,22(5):411-419
Background: There are still controversies about long-term clinical outcomes of sirolimus-eluting stents (SES) versus bare metal stents (BMS) implantation in patients with end-stage renal diseases (ESRD).
Objective: To compare long-term outcomes in patients with (ESRD) following SES versus BMS implantation.
Methods: Between March 2003 and July 2005, a total of 54 patients (80 lesions) with ESRD undergoing SES implantation [SES-ESRD] were enrolled and compared with 51 patients (54 lesions) with ESRD receiving BMS during the same periods [BMS-ESRD] in the Korean Multicenter Angioplasty Team Registry. The primary outcome was the composite of death, myocardial infarction (MI), or any stent thrombosis (ST) according to the Academic Research Consortium definition during a 3-year follow-up.
Results: The cumulative 3-year rate of composite of death, MI, or ST of the SES-ESRD group (24%) was nearly similar with that of the BMS-ESRD group (24%, P = 1.000). The 3-year rates of death (26% vs. 24%, P = 0.824) or MACE (37% vs. 43%, P = 0.331) in the SES-ESRD did not differ significantly from those in the BMS-ESRD. However, the SES-ESRD showed a sustained lower 3-year TVR rate (9%), compared with BMS-ESRD (24%, P = 0.042). The rate of any ST in SES-ESRD was not significantly higher than that in the BMS-ESRD (17% vs. 14%, P = 0.788). There was no significant difference in the rate of late or very late ST between SES-ESRD (15%) versus BMS-ESRD group (10%, P = 0.557).
Conclusions: SES did not increase the risks for death, MI, or any ST in patients with ESRD during the long-term follow-up, compared with BMS. 相似文献
Objective: To compare long-term outcomes in patients with (ESRD) following SES versus BMS implantation.
Methods: Between March 2003 and July 2005, a total of 54 patients (80 lesions) with ESRD undergoing SES implantation [SES-ESRD] were enrolled and compared with 51 patients (54 lesions) with ESRD receiving BMS during the same periods [BMS-ESRD] in the Korean Multicenter Angioplasty Team Registry. The primary outcome was the composite of death, myocardial infarction (MI), or any stent thrombosis (ST) according to the Academic Research Consortium definition during a 3-year follow-up.
Results: The cumulative 3-year rate of composite of death, MI, or ST of the SES-ESRD group (24%) was nearly similar with that of the BMS-ESRD group (24%, P = 1.000). The 3-year rates of death (26% vs. 24%, P = 0.824) or MACE (37% vs. 43%, P = 0.331) in the SES-ESRD did not differ significantly from those in the BMS-ESRD. However, the SES-ESRD showed a sustained lower 3-year TVR rate (9%), compared with BMS-ESRD (24%, P = 0.042). The rate of any ST in SES-ESRD was not significantly higher than that in the BMS-ESRD (17% vs. 14%, P = 0.788). There was no significant difference in the rate of late or very late ST between SES-ESRD (15%) versus BMS-ESRD group (10%, P = 0.557).
Conclusions: SES did not increase the risks for death, MI, or any ST in patients with ESRD during the long-term follow-up, compared with BMS. 相似文献