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21.
H Lange E Gotthardt U Hiller U Müller 《Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete》1985,40(3):82-84
The perivelvic extravasation is a rare X-ray symptom in the intravenous urography. Etiologic, diagnostic and therapeutic aspects are discussed on the basis of an own case and the present literature. 相似文献
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Rudolph G Gotthardt DN Kloeters-Plachky P Kulaksiz H Schirmacher P Stiehl A 《Digestive diseases and sciences》2011,56(12):3624-3630
Background
Patients with PSC and IBD have a high incidence of colonic carcinomas (CRC), and the annual incidence of CRC increases with duration of disease. UDCA treatment has been suggested to reduce colonic dysplasias and carcinomas. 相似文献24.
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Jessica Seessle Annina Gohdes Daniel Nils Gotthardt Jan Pfeiffenberger Nicola Eckert Wolfgang Stremmel Ulrike Reuner Karl Heinz Weiss 《Lipids in health and disease》2011,10(1):83
Introduction
Wilson disease (WD) is an inherited disorder of human copper metabolism, characterised by accumulation of copper predominantly in the liver and brain, leading to severe hepatic and neurological disease. Interesting findings in animal models of WD (Atp7b-/- and LEC rats) showed altered lipid metabolism with a decrease in the amount of triglycerides and cholesterol in the serum. However, serum lipid profile has not been investigated in large human WD patient cohorts to date.Patients and Methods
This cohort study involved 251 patients examined at the Heidelberg and Dresden (Germany) University Hospitals. Patients were analysed on routine follow-up examinations for serum lipid profile, including triglycerides, cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL). Data on these parameters at time of diagnosis were retrieved by chart review where available. For statistical testing, patients were subgrouped by sex, manifestation (hepatic, neurological, mixed and asymptomatic) and treatment (D-penicillamine, trientine, zinc or combination).Results
A significant difference in total serum cholesterol was found in patients with hepatic symptoms, which diminished under therapy. No alterations were observed for HDL, LDL and triglycerides.Conclusion
Contradictory to previous reports using WD animal models (Atp7b-/- and LEC rats), the most obvious alteration in our cohort was a lower serum cholesterol level in hepatic-affected patients, which might be related to liver injury. Our data suggested unimpaired cholesterol metabolism in Wilson disease under therapy, independent of the applied medical treatment.26.
Enayatullah Baki Philipp Zwickel Anna Zawierucha Robert Ehehalt Daniel Gotthardt Wolfgang Stremmel Annika Gauss 《World journal of gastroenterology : WJG》2015,21(11):3282-3290
AIM:To evaluate the outcome of anti-tumor necrosis factor alpha(anti-TNFα) therapy in outpatients with ulcerative colitis at a tertiary referral center.METHODS:All patients with a confirmed diagnosis of ulcerative colitis undergoing therapy with infliximab and/or adalimumab at the outpatient clinic for inflammatory bowel diseases at the University Hospital Heidelberg between January 2011 and February 2014 were retrospectively enrolled.Patients with a followup period of less than 6 mo from start of anti-TNFα therapy were excluded.Medical records of all eligible individuals were carefully reviewed.Steroid-free clinical remission of a duration of at least 3 mo,colectomy rate,duration of anti-TNFα therapy,need for anti-TNFα dose escalation,and the occurrence of adverse events were evaluated as the main outcome parameters.RESULTS:Seventy-two patients were included(35 treated with infliximab,17 with adalimumab,20 with both consecutively).Median follow-up was 27 mo(range:6-87 mo).Steroid-free clinical remission was achieved by 22.2% of the patients(median duration:21 mo until end of follow-up; range:3-66 mo).Patients attaining steroid-free clinical remission displayed lower hemoglobin and albumin blood levels at the start of treatment than those who did not achieve remission.The overall colectomy rate was 20.8%.Nearly 50% of the patients underwent anti-TNFα dose escalation during the follow-up period.For both the infliximab and the adalimumab treated patients,non-response to anti-TNFα therapy was the major reason for treatment discontinuation.18.2% of the infliximab-treated patients and 13.5% of the adalimumab-treated patients had to discontinue their therapy due to adverse events.CONCLUSION:Real-life remission rates of ulcerative colitis under anti-TNFα are overall low,but some patients have a clear long-term benefit. 相似文献
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Summary. Cloned Abutilon mosaic geminivirus (AbMV) has been re-transmitted to Abutilon sellovianum (syn. striatum) plants by a two-step combined agroinfection/grafting method. The symptoms induced were indistinguishable from the characteristic
mosaic of ornamental Abutilon plants. Therefore, we can exclude that a mixture of different AbMV variants is responsible for the striking variety of Abutilon leaf pattern elements. Analysis of the symptoms on consecutively infected leaves suggests that mosaic formation depends on
routing and timing of super-imposed virus waves.
Received March 9, 2000 Accepted April 28, 2000 相似文献
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