单项医疗设备经济效益分析方法初探

医疗设备的经济效益情况是医院经济管理的重要论题.单项医疗设备经济效益分析方法的研究对于提高医疗设备使用效率,降低运行成本具有实际意义.在这里,我们以我院医疗设备使用和管理的实际情况为背景,以简单可行作为出发点,总结一套单项医疗设备经济效益分析方法的研究方案,并从工作基础和条件、研究内容和途径、预期目标和工作步骤几个方面解析论述,力求找到一条简明的数据统计和分析的思路,希望在实际运用和理论分析的反复过程中,能够不断完善医疗设备经济效益分析方法的实用性和科学性,使之更有效应用于实际工作.     

三妙汤加味外洗治疗尖锐湿疣64例观察

目的:观察三妙汤加味外洗治疗尖锐湿疣的疗效。方法:治疗组64例用三妙汤外洗、对照组64例用疣必治外涂,均治疗1周。结果:总有效率治疗组96.88%、对照组为95.31%,两组比较无明显差异(P>0.05)。半年复发率治疗组10.41%、对照组32.00%,两组比较有显著性差异(P<0.05)。结论:三妙汤加味外洗治疗尖锐湿疣疗效好、复发率低。     

高聚生联合顺铂心包腔内灌注治疗肺癌致心包液的临床观察

Objective： To evaluate the therapeutic efficacy of injecting highly agglutinative staphylococcin （HASL） and cisplatin into pericardial cavity of lung cancer patients with pericardial effusion. Methods： 81 patients were randomized into two groups： 45 in the experimental group （HASL and Cisplatin） and 36 in the control group （Cisplatin）. At first pericardial effusion was drained out from a intrapericardial catheter and then different drugs were infused, respectively. 24 h after perfusion the draining continued again until drainage quantity was less than 30 mL every day. The draining lasted 10-15 days. Results： The response rate was 91.1% for the experimental group and 80.6% for the control group. There was no significant difference between the two groups （P〉0.05）. The complete remission was 77.8% for the experimental group and 52.8% for the control group, which was statistically significant difference （P〈0.05）. The adverse effects were myelosuppression and nausea and vomiting, which were 35.6% and 40.0% in the experimental group and 72.2% and 66.7% in the control group, respectively （P〈0.01, P〈0.05）. Conclusion： inject- ing HASL and cisplatin into pericardial cavity may be a better way to control pericardial effusion of lung cancer.     

体外Fas介导细胞凋亡的细胞周期特异性的检测方法

Objective： To establish a system in detecting the cell cycle specificity induced by recombinant human Fas ligand in vitro, so as to provide a reliable platform for further exploring the mechanism of cell cycle control and regulation in Fas-mediated apoptosis. Methods： The target cells-leukaemia cell lines and activated peripheral blood lymphocytes stimulated by phytohemagglutinin were incubated with recombinant human Fas ligand for 6 to 36 h, apoptosis was detected by sub-G1, common annexin-Ⅴ/PI and modified annexin Ⅴ and propidium iodide （API） methods and analysed by flow cytometry. Results： The modified API method demonstrated that Fas-mediated apoptosis was cell cycle specific and initiated at G1 phase. The common annexinⅤ/PI method showed the most appropriate condition for the detection of typical cell cycle-specific apoptosis. The sub-G1 method could only illuminate late apoptosis and DNA histogram. Conclusion： Fas-mediated apoptosis was cell cycle-specific and initiated at G 1 phase. Based on the modified API and common AnnexinⅤ/PI methods, the establishment of stable and typical cell cycle-specific model in Fas-mediated apoptosis in vitro was feasible.     

单臂半环式三维固定胫腓骨骨折支架的生物力学实验及临床应用

为观察自制单臂半环胫腓骨骨折固定器治疗胫腓骨骨折的生物力学效应和临床疗效,选择成人离体新鲜骨1具,新鲜牛胫腓骨4具(其中2具备用),分别制作成斜形、横断形、粉碎性骨折模型,以骨折复位器模拟临床治疗方法将之复位固定后,固定于电子万能试验机上,分别对3种模型模拟骨折固定后的6种受力状态(施加轴向拉伸力、轴向压缩力、前后向弯曲压力、侧向弯曲压力、左扭转力、右扭转力)进行试验,观察骨折端位移,分别记录试验数据、坐标曲线图。同时对50例胫腓骨骨折患者进行临床观察。结果显示,对骨折复位固定后的模型施加较常规外力可增加数倍的力,骨折复位固定器及骨折端本身的位移数均在许可范围。经50例临床应用观察,骨折全部愈合。表明该复位固定器设计力学结构合理,无偏心应力,具有弹性固定功能,性能稳定,能有效维持骨折复位效果的作用。且操作简便、固定牢靠、实用。     

高效液相色谱法测定盐酸达克罗宁乳膏含量

目的:建立盐酸达克罗宁乳膏中盐酸达克罗宁含量测定的高效液相色谱法。方法:采用C18色谱柱,流动相为乙腈-0．02 mol·L-1磷酸二氢钾(用磷酸调pH至3．0)(60:40),检测波长为282 nm,流速为0．9 ml·min-1。结果:盐酸达克罗宁浓度在9．98-49．90 mg·L-1范围内与峰面积呈良好的线性关系(r=0．999 9),平均回收率为98．55％(RSD％为1．19％)。结论:本法简便、快捷,结果准确,适用于该制剂的质量分析检验。     

Interference with the formation of the epididymal microenvironment-a new strategy for male contraception？

The cystic fibrosis transmembrane conductance regulator (CFTR) or the small conductance cAMP-activated chloride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymal fluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germ cells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching and widespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its intervention by pharmacological agents can open a new avenue of research into the development of novel male contraceptives. ( Asian J Androl 2000 ; 2 : 39 - 45 )