全文获取类型
收费全文 | 6241篇 |
免费 | 609篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 67篇 |
儿科学 | 197篇 |
妇产科学 | 157篇 |
基础医学 | 797篇 |
口腔科学 | 300篇 |
临床医学 | 610篇 |
内科学 | 1266篇 |
皮肤病学 | 208篇 |
神经病学 | 543篇 |
特种医学 | 255篇 |
外国民族医学 | 1篇 |
外科学 | 1019篇 |
综合类 | 124篇 |
现状与发展 | 30篇 |
预防医学 | 372篇 |
眼科学 | 66篇 |
药学 | 321篇 |
中国医学 | 12篇 |
肿瘤学 | 537篇 |
出版年
2023年 | 207篇 |
2022年 | 56篇 |
2021年 | 140篇 |
2020年 | 151篇 |
2019年 | 162篇 |
2018年 | 217篇 |
2017年 | 157篇 |
2016年 | 164篇 |
2015年 | 206篇 |
2014年 | 267篇 |
2013年 | 278篇 |
2012年 | 317篇 |
2011年 | 306篇 |
2010年 | 250篇 |
2009年 | 242篇 |
2008年 | 236篇 |
2007年 | 281篇 |
2006年 | 219篇 |
2005年 | 231篇 |
2004年 | 203篇 |
2003年 | 212篇 |
2002年 | 216篇 |
2001年 | 150篇 |
2000年 | 156篇 |
1999年 | 153篇 |
1998年 | 91篇 |
1997年 | 98篇 |
1996年 | 77篇 |
1995年 | 76篇 |
1994年 | 75篇 |
1993年 | 75篇 |
1992年 | 104篇 |
1991年 | 95篇 |
1990年 | 103篇 |
1989年 | 104篇 |
1988年 | 79篇 |
1987年 | 94篇 |
1986年 | 60篇 |
1985年 | 72篇 |
1984年 | 45篇 |
1983年 | 41篇 |
1982年 | 25篇 |
1981年 | 33篇 |
1980年 | 25篇 |
1979年 | 38篇 |
1978年 | 30篇 |
1976年 | 27篇 |
1973年 | 26篇 |
1972年 | 23篇 |
1967年 | 25篇 |
排序方式: 共有6882条查询结果,搜索用时 15 毫秒
101.
Helmut Schröder Michelle A. Mendez Santiago F. Gomez Montserrat Fíto Lourdes Ribas Javier Aranceta Lluis Serra-Majem 《Nutrition (Burbank, Los Angeles County, Calif.)》2013,29(11-12):1350-1355
ObjectivesTo determine the impact of energy density on diet quality and anthropometric proxy measures for central body fat in young Spaniards.MethodsData were obtained from a representative national sample of 2513 young Spaniards aged 10 to 24 y. Dietary assessment was performed with a 24-h recall. Adherence to the Mediterranean diet was measured by the KIDMED index. Reduced rank regression analysis was used to identify energy-density dietary patterns. Waist circumferences and height were measured.ResultsPastries and sausages showed the strongest loading for the dietary energy density factor score (DED-FS), with fruits and vegetables at the opposite end of the scale. Multiple linear regression analysis showed a positive association (P < 0.01) of dietary energy density (DED) and the DED-FS with waist circumferences regressed on height and age (WCheight+age) and waist-to-height ratio (WHtR). The adjusted odds ratio for elevated WCheight+age and WHtR increased across quartile distribution of DED (P < 0.001) and DED-FS (P < 0.05). Diet quality characterized by the KIDMED index was negatively associated (P < 0.001) with DED and the DED-FS.ConclusionsHigher DED is a risk for increased central fat distribution and is associated with low adherence to the Mediterranean diet. 相似文献
102.
103.
Vanesa Martín Ana María Sanchez‐Sanchez Noelia Puente‐Moncada Marina Gomez‐Lobo Marco Antonio Alvarez‐Vega Isaac Antolín Carmen Rodriguez 《Journal of pineal research》2014,57(3):308-316
Glioblastoma‐initiating cells (GICs) represent a stem cell‐like subpopulation within malignant glioblastomas responsible for tumor development, progression, therapeutic resistance, and tumor relapse. Thus, eradication of this subpopulation is essential to achieve stable, long‐lasting remission. We have previously reported that melatonin decreases cell proliferation of glioblastoma cells both in vitro and in vivo and synergistically increases effectiveness of drugs in glioblastoma cells and also in GICs. In this study, we evaluated the effect of the indolamine alone in GICs and found that melatonin treatment reduces GICs proliferation and induces a decrease in self‐renewal and clonogenic ability accompanied by a reduction in the expression of stem cell markers. Moreover, our results also indicate that melatonin treatment, by modulating stem cell properties, induces cell death with ultrastructural features of autophagy. Thus, data reported here reinforce the therapeutic potential of melatonin as a treatment of malignant glioblastoma both by inhibiting tumor bulk proliferation or killing GICs, and simultaneously enhancing the effect of chemotherapy. 相似文献
104.
M. Larrosa A. Gomez E. Casado M. Moreno I. Vázquez C. Orellana E. Berlanga J. Ramon J. Gratacos 《Osteoporosis international》2012,23(2):607-614
Summary
In a cross-sectional study including 324 patients older than 65 years admitted to our hospital for osteoporotic hip fracture, we found that those patients with a more severe vitamin D deficiency had more severe osteoporotic hip fractures (Garden grades III–IV and Kyle III–IV). 相似文献105.
106.
A. Gomez‐Cabello R. Pedrero‐Chamizo P. R. Olivares L. Luzardo A. Juez‐Bengoechea E. Mata U. Albers S. Aznar G. Villa L. Espino N. Gusi M. Gonzalez‐Gross J. A. Casajus I. Ara 《Obesity reviews》2011,12(8):583-592
Coupled with the growth of the older population, an increase in the prevalence of overweight and obesity in this age group has occurred in the last decades. The main aims of the present study were (i) to provide an updated prevalence of overweight and obesity in a representative sample of the Spanish elderly population; (ii) to calculate the prevalence of sarcopenic obesity (SO) and (iii) to analyse the relationships between adiposity measurements and lifestyle. A cross‐sectional study was carried out in a sample of 3136 persons representative of the non‐institutionalized population ≥65 years of age. Anthropometric measurements were obtained using standardized techniques and equipment. Overall, 84% of the population can be categorized as overweight and/or obese. The present study indicates that 67% of the Spanish elderly population has an increased percentage of fat mass and more than 56% suffer from central obesity. Moreover, SO is present in 15% of the Spanish elderly population. Finally, a strong relationship between both physically active and sedentary lifestyles and the level of adiposity was found. Prevalence of overweight and obesity among elderly people in Spain is very high and is still increasing. Lifestyle seems to be a determinant factor in the development of obesity among elderly people. 相似文献
107.
108.
109.
Núbia Braga Pereira Ana Carolina de Melo do Carmo Marina Gon?alves Diniz Ricardo Santiago Gomez Dawidson Assis Gomes Carolina Cavalieri Gomes 《Oncotarget》2015,6(12):9679-9685
Background: Ameloblastoma is a locally invasive neoplasm often associated with morbidity and facial deformities, showing increased Epidermal Growth Factor Receptor (EGFR) expression. Inhibition of EGFR was suggested as a treatment option for a subset of ameloblastomas. However, there are resistance mechanisms that impair anti-EGFR therapies. One important resistance mechanism for EGFR-inhibition is the EGFR nuclear localization, which activates genes responsible for its mitogenic effects, such as Cyclin D1.Methods: We assessed EGFR nuclear localization in encapsulated (unicystic, n = 3) and infiltrative (multicystic, n = 11) ameloblastomas and its colocalization with Cyclin D1 by using anti-EGFR and anti-lamin B1 double labeling immunofluorescence analyzed by confocal microscopy. Oral inflammatory fibrous hyperplasia and oral squamous cell carcinoma samples were used for comparison.Results: Twelve cases of ameloblastoma exhibited nuclear EGFR colocalization with lamin B1. This positive staining was mainly observed in the ameloblast-like cells. The EGFR nuclear localization was also observed in control samples. In addition, nuclear EGFR colocalized with Cyclin D1 in ameloblastomas.Conclusions: Nuclear EGFR occurs in ameloblastomas in association with Cyclin D1 expression, which is important in terms of tumor biology clarification and raises a concern about anti-EGFR treatment resistance in ameloblastomas. 相似文献
110.