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Pramod P. Kattimani Shilpa M. Somagond Praveen K. Bayannavar Ravindra R. Kamble Subhas C. Bijjaragi Raveendra K. Hunnur Shrinivas D. Joshi 《Drug development research》2020,81(1):70-84
In this study, we report the ring transformation of 3-arylsydnone into 1-aryl-1H-pyrazole-3-carbonitriles via [3 + 2] cycloaddition with acrylonitrile. 1-Aryl-1H-pyrazole-3-carbonitrile underwent [2 + 3] cycloaddition with sodium azide to afford 5-(1-aryl-1H-pyrazol-3-yl)-1H-tetrazoles which were further subjected to N-alkylation with aryl/heteroaryl alkyl halides to afford 1,5- and 2,5-disubstituted tetrazoles. Furthermore, the title compounds were screened for in vivo antihyperglycemic activity using albino Wistar rats of either sex. Compounds 4a , 6b , 7a , 7b , 8b , and 9b showed maximum fall in the blood glucose levels in streptozotocin-induced diabetic rats after 5–7 days of administration. In support of antidiabetic activity, we also performed the experimental in vivo studies, namely, effect of compounds on enzymes (serum glutamic oxaloacetic transaminase, serum glutamic-pyruvic transaminase, creatinine, urea, and total protein), antihyperlipidemic, and histopathology. Moreover, the molecular docking study has been performed for potent molecules among the series with glycogen phosphorylase as target enzyme, and this study corroborated the experimental in vivo results. 相似文献
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Subhas Chandra Jana 《Journal of basic microbiology》1994,34(1):31-35
Electrophoretic comparison of isoenzymes of the members of Azotobacteraceae suggests that the genus Azotobacter consists of a heterogeneous group of bacteria. The new name Azomonotrichon macrocytogenes for Azomonas macrocytogenes is supported by the present investigation which was proposed earlier by numerical analysis study. 相似文献
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Biswadip Banerji Sumit Kumar Pramanik Priyankar Sanphui Sameer Nikhar Subhas C. Biswas 《Chemical biology & drug design》2013,82(4):401-409
Cancer continues to be one of the biggest threats to the human civilization because there is no cure of it. Small heterocyclic molecule with low molecular weight and novel structural feature is therapeutically highly demanding. These molecules have the capability to disrupt signaling pathways leading to anticancer activities. Therefore, the search for new anticancer agents continues to draw attention to the research community. In this study, a small triazolo‐benzoxazepine scaffolds was synthesized using a one‐pot four‐step synthetic methodology involving click reaction. Small libraries of 12 compounds were successfully synthesized and screened them against different cancer cell lines. Low micromolar anticancer activity was recorded using MTT assay, and further confirmation of cell death was obtained by phase contrast, fluorescent, and confocal images. 相似文献
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