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991.
Jong Eun Lee Jin Woong Kim Hyoung Ook Kim Byung Chan Lee Young Hoe Hur Sung Bum Cho Yong Soo Cho Hyun Ju Seon DongHun Kim 《Journal of vascular and interventional radiology : JVIR》2019,30(3):370-379.e4
Purpose
To evaluate the effects of the degree of ethiodized oil accumulation achieved by transarterial chemoembolization followed by radiofrequency (RF) ablation on the treatment efficacy for a single intermediate-sized hepatocellular carcinoma (HCC).Materials and Methods
A total of 153 consecutive patients who underwent chemoembolization and RF ablation for a single intermediate-sized HCC (2–5 cm) were included. On the basis of the degree of ethiodized oil accumulation in HCC on cone-beam CT images, patients who underwent chemoembolization and RF ablation were classified into 2 groups: compact accumulation (≥ 75%) and noncompact accumulation (< 75%). The rates of cumulative local tumor progression (LTP), disease-free survival (DFS), and overall survival (OS) were compared between groups.Results
Of the 153 patients, 89 were classified into the compact ethiodized oil accumulation group and 64 in the noncompact ethiodized oil accumulation group. There were no significant differences in patient demographic or HCC characteristics between groups except for the incidence of liver cirrhosis (P = .038) and the tumor margin morphology (P = .008). The cumulative LTP rate was significantly lower in the compact accumulation group than in the noncompact accumulation group (P = .013). There were no significant differences in the incidences of complications, DFS rates (P = .055), or OS rates (P = .184).Conclusions
The degree of ethiodized oil accumulation does not play a role in decreasing the OS or DFS rate after chemoembolization and RF ablation for intermediate-sized HCC; however, it may contribute to reducing the rate of LTP. 相似文献992.
Kevin G. Billingsley M.D. Kwan Hur Ph.D. William G. Henderson Ph.D. Jennifer Daley M.D. Shukri F. Khuri M.D. Richard H. Bell Jr. M.D. 《Journal of gastrointestinal surgery》2003,7(4):484-491
The aim of this study is to define the risk factors that predict adverse outcomes for patients undergoing pancreaticoduodenectomy
for periampullary cancer in the Department of Veterans Affairs Healthcare System (VA). The VA National Surgical Quality Improvement
Program prospectively collected data on 462 patients undergoing pancreaticoduodenectomy in 123 VA medical centers from 1990
to 2000. Independent variables included 68 preoperative and 12 intraoperative variables. The main outcome measures were 30-day
postoperative mortality and morbidity, as measured by a set of 20 pre-defined complications. Predictive models for 30-day
morbidity and mortality were constructed using logistic regression analysis. The 30-day morbidity rate was 45.9% (212/462).
The 30-day postoperative mortality rate was 9.3% (43/462). Significant predictors of mortality included: preoperative serum
albumin, American Society of Anesthesiologists classification, preoperative bilirubin >20mg/dl, and operative time. The use
of preoperative biliary tract instrumentation did not predict postoperative death or septic complications. This study provides
a set of preoperative risk factors that are predictive of adverse outcome following pancreaticoduodenectomy. These factors
may assist in patient selection for this procedure and are likely to facilitate risk-adjusted comparison of pancreaticoduodenectomy
outcomes between different health care systems.
Presented at the Forty-Third Annual Meeting of The Society for Surgery of the Alimentary Tract, San Francisco, California,
May 19–22, 2002 (poster presentation). 相似文献
993.
Francesco Bruno MD Jeehoon Kang MD Edoardo Elia MD Jung-Kyu Han MD Ovidio De Filippo MD Han-Mo Yang MD Guglielmo Gallone MD Kyung-Woo Park MD Leonardo De Luca MD Hyun-Jae Kang MD Giorgio Quadri MD Hyeon-Cheol Gwon MD Woo Jung Chun MD Giuseppe Giannino MD Seung-Ho Hur MD Seung Hwan Han MD Alessandra Truffa MD Young Bin Song MD Bernardo Cortese MD Ki Hong Choi MD Alaide Chieffo MD Soon-Jun Hong MD Gianluca Di Pietro MD Joon-Hyung Doh MD Wojciech Wanha MD Chang-Wook Nam MD Hyo-Soo Kim MD Alessio Mattesini MD Gaetano Maria de De Ferrari MD Bon-Kwon Koo MD Fabrizio D'Ascenzo MD PhD 《Catheterization and cardiovascular interventions》2023,102(4):620-630
994.
Purpose
Laparoscopic colectomy has clinical benefits such as short hospital stay, less postoperative pain, and early return of bowel function. However, objective evidence of its immunologic and oncologic benefits is scarce. We compared functional recovery after open versus laparoscopic sigmoidectomy and investigated the effect of open versus laparoscopic surgery on acute inflammation as well as tumor stimulation.Materials and Methods
A total of 57 patients who were diagnosed with sigmoid colon cancer were randomized for elective conventional or laparoscopically assisted sigmoidectomy. Serum samples were obtained preoperatively and on postoperative day 1. C-reactive protein (CRP) and interleukin-6 (IL-6) were measured as inflammation markers, and vascular endothelial growth factor (VEGF) and insulin-like growth factor binding protein-3 (IGFBP-3) were used as tumor stimulation factors. Clinical parameters and serum markers were compared.Results
Postoperative hospital stay (p=0.031), the first day of gas out (p=0.016), and the first day of soft diet (p<0.001) were significantly shorter for the laparoscopic surgery group than the open surgery group. The levels of CRP, IL-6, and VEGF rose significantly, and the concentration of IGFBP-3 fell significantly after both open and laparoscopic surgery. However, there were no significant differences in the preoperative and postoperative levels of CRP, IL-6, VEGF, and IGFBP-3 between the two groups.Conclusion
Our data suggest that both open and laparoscopic surgeries are accompanied by significant changes in IL-6, CRP, IGFBP-3, and VEGF levels. Acute inflammation markers and tumor stimulating factors may not reflect clinical benefits of laparoscopic surgery. 相似文献995.
Cristiane Matté Ben Hur M. MussuliniTiago M. dos Santos Flávia M.S. SoaresFabrício Simão Aline MattéDiogo L. de Oliveira Christianne G. SalbegoSusana T. Wofchuk Angela T.S. Wyse 《International journal of developmental neuroscience》2010
In the present study we evaluated the effect of acute and chronic homocysteine administrations on glutamate uptake in parietal cortex of rats. The immunocontent of glial glutamate transporter (GLAST) and sodium-dependent glutamate/aspartate transporter (GLT-1) in the same cerebral structure was also investigated. For acute treatment, neonate or young rats received a single injection of homocysteine or saline (control) and were sacrificed 1, 8, 12 h, 7 or 30 days later. For chronic treatment, homocysteine was administered to rats twice a day at 8 h interval from their 6th to their 28th days old; controls and treated rats were sacrificed 12 h, 1, 7 or 30 days after the last injection. Results show that acute hyperhomocysteinemia caused a reduction on glutamate uptake in parietal cortex of neonate and young rats, and that 12 h after homocysteine administration the glutamate uptake returned to normal levels in young rats, but not in neonate. Chronic hyperhomocysteinemia reduced glutamate uptake, and GLAST and GLT-1 immunocontent. According to our results, it seems reasonable to postulate that the reduction on glutamate uptake in cerebral cortex of rats caused by homocysteine may be mediated by the reduction of GLAST and GLT-1 immunocontent, leading to increased extracellular glutamate concentrations, promoting excitotoxicity. 相似文献
996.
Seung Yoon Song Seong Yeol Ahn Jong Ju Rhee Jong Won Lee Jin Woo Hur Hyun Koo Lee 《Journal of Korean Neurosurgical Society》2015,58(4):321-327
ObjectiveTo determine whether the use of contrast enhancement (especially its extent) predicts malignant brain edema after intra-arterial thrombectomy (IAT) in patients with acute ischemic stroke.MethodsWe reviewed the records of patients with acute ischemic stroke who underwent IAT for occlusion of the internal carotid artery or the middle cerebral artery between January 2012 and March 2015. To estimate the extent of contrast enhancement (CE), we used the contrast enhancement area ratio (CEAR)-i.e., the ratio of the CE to the area of the hemisphere, as noted on immediate non-enhanced brain computed tomography (NECT) post-IAT. Patients were categorized into two groups based on the CEAR values being either greater than or less than 0.2.ResultsA total of 39 patients were included. Contrast enhancement was found in 26 patients (66.7%). In this subgroup, the CEAR was greater than 0.2 in 7 patients (18%) and less than 0.2 in the other 19 patients (48.7%). On univariate analysis, both CEAR ≥0.2 and the presence of subarachnoid hemorrhage were significantly associated with progression to malignant brain edema (p<0.001 and p=0.004), but on multivariate analysis, only CEAR ≥0.2 showed a statistically significant association (p=0.019). In the group with CEAR ≥0.2, the time to malignant brain edema was shorter (p=0.039) than in the group with CEAR <0.2. Clinical functional outcomes, based on the modified Rankin scale, were also significantly worse in patients with CEAR ≥0.2 (p=0.003)ConclusionThe extent of contrast enhancement as noted on NECT scans obtained immediately after IAT could be predictive of malignant brain edema and a poor clinical outcome. 相似文献
997.
Junseok W. Hur Youn-Kwan Park Bum-Joon Kim Hong-Joo Moon Joo-Han Kim 《Journal of Korean Neurosurgical Society》2016,59(4):368-373
ObjectiveDelayed hinge fracture (HF) that develops after cervical open door laminoplasty can be a source of postoperative complications such as axial pain. However, risk factors related to this complication remain unclear. We performed a retrospective clinical series to determine risk factors for delayed HF following plate-only open-door cervical laminoplasty.MethodsPatients who underwent plate-only open-door laminoplasty and had available postoperative computed tomography (CT) scans (80 patients with 270 laminae) were enrolled. Hinge status, hinge gutter location, open location, hinge width, number of screws used, operation level, and open angle were observed in the CT to determine radiographic outcome. Demographic data were collected as well. Radiographic and clinical parameters were analyzed using univariate and multivariate logistic regression analysis to determine the risk factors for HF.ResultsUnivariate logistic regression analysis results indicated poor initial hinge status, medially placed hinge gutter, double screw fixation on the elevated lamina, upper surgical level, and wide open angle as predictors for HF (p<0.05). Initial hinge status seemed to be the most powerful risk factor for HF (p=0.000) and thus was collinear with other variables. Therefore, multivariate logistic regression analysis was performed excluding initial hinge status, and the results indicated that medially placed hinge gutter, double screw fixation on the elevated lamina, and upper surgical level were risk factors for HF after adjustment for other confounding factors.ConclusionTo prevent HF and to draw a successful postoperative outcome after cervical laminoplasty, surgical and clinical precautions should be considered. 相似文献
998.
Brooke S.G. Molina Stephen P. Hinshaw L. Eugene Arnold James M. Swanson William E. Pelham Lily Hechtman Betsy Hoza Jeffery N. Epstein Timothy Wigal Howard B. Abikoff Laurence L. Greenhill Peter S. Jensen Karen C. Wells Benedetto Vitiello Robert D. Gibbons Andrea Howard Patricia R. Houck Kwan Hur Sue Marcus 《Journal of the American Academy of Child and Adolescent Psychiatry》2013,52(3):250-263
999.
1000.
正Sensory cell damage is a major cause of hearing loss:Sensorineural hearing loss(SNHL)is a common sensory defici characterized by tissue damage and/or cell death in the cochlea Moderate and severe SNHL causes deficits in communication associated with increased isolation from human relationships and negativly impacts employability.Many etiologies have been associated with SNHL:Noise overexposure,certain drugs,inner or middle ear infection or immune-induced inflammation 相似文献