Peripheral blood leukocyte telomere length is associated with age but not renal function: A cross-sectional follow-up study

Objectives

We aimed to evaluate the relationship between baseline renal function and changes in telomere length in Han Chinese.

Methods

The telomere restriction fragment (TRF) length of leukocytes in the peripheral blood was measured in healthy volunteers recruited in 2014. The estimated glomerular filtration rate (eGFR) was calculated based on serum creatinine (Scr) and serum cystatin C (CysC)-eGFRcys and eGFRScr-cys through the Cockcroft-Gault formula (eGFRC-G) or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI / eGFRCKD-EPI) equation. The correlation between telomere length changes over time and renal function was analyzed.

Results

Leukocyte TRF lengths were negatively correlated to age (r = -0.393, p < 0.001) and serum CysC (r = -0.180, p < 0.01), while positively associated with eGFRCKD-EPI, eGFRC-G, eGFRcys, and eGFRScr-cys (r = 0.182, 0.122, 0.290, and 0.254 respectively, p < 0.01). The 3-year change of telomere length was 46 bp/years. When adjusted for age, the associations between telomere length changes and baseline, subsequent TRF lengths, and serum CysC were no longer present. No association was observed between TRF length changes and renal function.

Conclusion

The rate of telomere length changes was affected by age and baseline telomere length. The telomere length changes might be important markers for aging.

     

A Representative Study of Deaths of North Indian Migrants and Its Medical Certification Across the World

Many Indians is moving to other nations of the world in the search of employment, education or other reasons. The process of globalization along with the faster mode of traveling and communication has facilitated this movement in the hope of getting more opportunities and earning of easy money abroad, than in India. Unfortunately, sometimes they meet a tragic end and their families in India get only their dead bodies back from abroad. This study focuses on these kind of unfortunate tragic events faced by Indians in different countries and thereby raise a concern on their safety abroad and necessitate the need of relooking in to the quality of medical certification of death and medico legal investigations to find out the real reasons of deaths to avoid any kind of doubt in mind. Data was collected from medical death certificates and passports of the deceased Indians. There was a total of 711 dead bodies/human remains received in 2012 at IGI airport New Delhi. The Middle East countries together contributed a total of 398 (55.98?%) cases. The distribution as per manner of death shows that in maximum number of cases (269), the manner of death was ambiguous with unspecified aetiology. The study therefore recommends for upgradation of the level of medico legal investigations in form of 2nd autopsy in recipient country and proper medical death certification.     

Fissure sealant retention: a comparison of three sealant types under field conditions

Two two-year double-blind clinical trials were undertaken involving the newly-erupted first permanent molars of 133 children aged 5-6 years at the outset. In one study of 76 subjects, half the teeth were sealed with the filled sealants Prismashield or Estiseal. In the other study of 58 children, half were again sealed with Prismashield, and the others with the unfilled Concise white sealant, by a community dental service hygienist, as part of her routine dental duties. Subjects were examined under blind conditions at 6 monthly intervals and, by 24 months in the first study, 71 per cent of Prismashield sites were intact and caries-free, compared with only 53 per cent of Estiseal-treated tooth units (P less than 0.001). In the second study comparing Prismashield and Concise, by two years, 81 per cent of Prismashield resins were complete, compared with 88 per cent of the nonfilled Concise material. There were, however, no differences noted with respect to buccal and palatal site retention for either study. It can be concluded that Estiseal is a poorer material than Prismashield, certainly in relation to its bulk retention properties. Nonetheless it is possible that, along with other tooth-coloured/transparent resins, small fragments may not be as readily detectable as is the case with the unfilled Concise white sealant. However, as the abrasion resistance of unfilled materials is poorer than that of filled resins, the similar buccal/palatal site retention for Prismashield and Concise was also unexpected. Nevertheless this study illustrates again the value of sealant placement in the erupting first permanent molars of 5-6-year-old children, at a time when these teeth are most susceptible to carious attack.