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701.
Tomofumi Naruse Souichi Yanamoto Shin-ichi Yamada Satoshi Rokutanda Akiko Kawakita Hidenori Takahashi Yuki Matsushita Saki Hayashida Naomi Imayama Kota Morishita Kentaro Yamashita Goro Kawasaki Masahiro Umeda 《Indian journal of otolaryngology and head and neck surgery》2015,67(1):67-73
Although lipomas are common soft tissue tumors, few cases of lipoma or its variants have been reported in the oral cavity. We here described the clinical, histological, and immunohistochemical features of 24 cases of oral lipoma obtained from medical records at Nagasaki University Hospital between 1977 and 2010, and also retrospectively reviewed 603 cases of oral lipoma reported in the English literatures. The patients examined comprised 11 men and 13 women with a mean age of 59 years, ranging from 31 to 90 years. The main sites involved were the buccal mucosa (n = 9), followed by the tongue (n = 4), lip and retromolar area (n = 3), floor of the mouth (n = 2), and gingiva (n = 1). The mean tumor size was 2.0 cm, ranging from 0.2 to 5 cm. Histological analysis revealed 20 cases of lipoma, 2 cases of fibrolipoma, and one case each of intramuscular lipoma and spindle cell lipoma. Twenty-three cases were treated surgically while one case underwent biopsy and follow-up. Recurrence was not observed in any case. We reviewed the English literatures, and similar results were obtained. In immunohistochemical analysis, PCNA and ki-67 expression indices were higher in intramuscular lipoma cases than in its variants. Especially, it showed that a long time follow-up may be necessary in ki-67 positive cases. 相似文献
702.
Hideaki Shiraishi Kenji Yamada Kiyoshi Egawa Mika Ishige Fumihiro Ochi Asami Watanabe Sanae Kawakami Kazuyo Kuzume Kenji Watanabe Koji Sameshima Kiyotaka Nakamagoe Akira Tamaoka Naoko Asahina Saki Yokoshiki Keiko Kobayashi Takashi Miyakoshi Koji Oba Toshiyuki Isoe Norihiro Sato 《Brain & development》2021,43(2):214-219
BackgroundVery long-chain acyl-CoA dehydrogenase deficiency (VLCADD) is a mitochondrial fatty acid oxidation disorder that causes episodic attacks, such as general fatigue, hypotonia, myalgia, and rhabdomyolysis accompanied by lack of energy. As yet, there are no preventative drugs for these VLCADD-associated metabolic attacks.Patients and methodsWe conducted an open-label, non-randomized, multi-center study into the effects of bezafibrate on five patients with VLCADD. Bezafibrate was administered for 4 years, and we analyzed the number of myopathic attacks requiring hospitalization and treatment infusions.ResultsThe number of myopathic attacks requiring infusions of 24 h or longer significantly decreased during the study period. The patients’ ability to conduct everyday activities was also improved by the treatment.ConclusionOur findings show the potential long-term efficacy of bezafibrate in preventing myopathic attacks for patients with VLCADD. 相似文献
703.
Ghashghaeinia M Cluitmans JC Akel A Dreischer P Toulany M Köberle M Skabytska Y Saki M Biedermann T Duszenko M Lang F Wieder T Bosman GJ 《British journal of haematology》2012,157(5):606-614
Mature, circulating erythrocytes undergo senescence, which limits their life span to approximately 120 d. Upon injury, erythrocytes may undergo suicidal erythrocyte death or eryptosis, which may accelerate senescence and shorten their survival. Eryptosis is defined as cell shrinkage and exposure of phosphatidylserine at the cell surface. Triggers of eryptosis include oxidative stress. The present study addresses the impact of erythrocyte age on the relative susceptibility to eryptosis. Erythrocytes were separated into five fractions, based on age-associated differences in density and volume. Cell membrane scrambling was estimated from binding of annexin V to phosphatidylserine at the erythrocyte surface, the cell volume from forward scatter, and the Ca(2+) level from Fluo-3-dependent fluorescence. In addition, glutathione (GSH) concentrations were measured by an enzymatic/colourimetric method. After 48 h incubation in Ringer solution, Annexin V binding increased significantly with erythrocyte age. The differences were not accompanied by altered GSH concentrations, but were reversed by addition of the antioxidant N-acetyl-L-cysteine in vitro. Also, N-acetyl-L-cysteine significantly prolonged the half-life of circulating mouse erythrocytes in vivo. Thus, the susceptibility to eryptosis increases with the age of the erythrocytes, and this effect is at least partially due to enhanced sensitivity to oxidative stress. 相似文献
704.
Matsuda S Yamaguchi T Okada K Gotouda A Mikami S 《Journal of prosthodontic research》2012,56(1):37-41
PurposeThe purpose of this study was to clarify the day-to-day variations of salivary cortisol to discuss the appropriate timing for collecting saliva in a day for stress evaluation.Materials and methodsSaliva samples from twelve healthy adults were collected by means of Salivette® (SARSTEDT Co.) three times per day, immediately after awakening (Time1), 6:00 PM (Time2) and 30 min before going to bed (Time3), on 5 nonconsecutive days. Cortisol concentration was measured using a radioimmunoassay.ResultsSalivary cortisol concentration showed the larger value at Time1 than that at Time2. The mean value of %CV for day-to-day variation showed the smallest value at Time1 (mean: 43.1%) and the largest value at Time3 (mean: 100.3%). There were significant differences in %CV value between Time1 and Time3, Time2 (mean: 64.1%) and Time3.ConclusionsThere are considerable day-to-day variations in salivary cortisol concentration measurements. From the viewpoint of day-to-day variation, collecting saliva immediately after awakening in the morning is thought to be more advantageous for evaluating cortisol concentration. 相似文献
705.
706.
Vahedian Zakieh Fakhraie Ghasem Ghasemi Mehrnoosh Azimi Ali Tabatabaei Seyed Mehdi 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(12):3935-3944
Graefe's Archive for Clinical and Experimental Ophthalmology - To compare outer macular and retinal thickness in the circumpapillary area in unilateral advanced glaucomatous eyes to the normal... 相似文献
707.
Behavioral effects of infection with IL-6 adenovector 总被引:2,自引:0,他引:2
The onset of autoimmunity in lupus-prone mice is accompanied by a constellation of behavioral deficits, termed Autoimmunity-Associated Behavioral Syndrome (AABS). In particular, a spontaneous increase in serum interleukin-6 (IL-6) levels in five-week old MRL-lpr mice coincides temporally with blunted responsiveness to sucrose and excessive immobility in the forced swim test. These relationships, along with evidence that sucrose intake drops after systemic IL-6 overexpression is induced in healthy mice, have led to the hypothesis that sustained elevation in serum IL-6 also induces other aspects of AABS. This hypothesis is tested by comparing the behavioral profiles of healthy mice infected with Ad5mIL6 adenovirus (2 x 10(8) pfu of virus/mouse i.p.) with those of animals infected with control Ad5 virus. This methodology was used to achieve high circulating levels of IL-6, to overcome the problem of its short half-life, and to avoid the stressful effects of repeated injections. The Ad5mIL6 infection (known to induce excessive IL-6 levels over five days) transiently reduced food, water, and sucrose intake, as well as rectal temperature in MRL +/+ and AKR/J mice. Although the level of locomotor activity did not decline, Ad5mIL6-infected AKR/J mice demonstrated less novel object exploration. Performance in the step-down, plus-maze, and spontaneous alternation tests were disturbed to various degrees in all infected animals. The present results suggest that prolonged exposure to circulating IL-6 primarily impairs ingestive behavior, likely reflecting enhanced catabolism. The inability of circulating IL-6 to alter other aspects of behavior supports the hypothesis that multiple immuno-neuroendocrine mechanisms contribute to the pathogenesis of AABS. 相似文献
708.
Makoto Ishitobi Osamu Suzuki Yoshifumi Komoike Shozo Ohsumi Saki Nakahara Toshinari Yagi Tetsuhiro Yoshinami Yasuhiko Tomita Hideo Inaji 《Breast cancer (Tokyo, Japan)》2014,21(5):550-556
Backgrounds
The aim of this study was to assess the efficacy and safety of neoadjuvant anastrozole and radiation in postmenopausal breast cancer patients with hormone-receptor-positive tumors. In addition, we assessed the predictive factors for clinical and pathological response for concurrent anastrozole and radiotherapy.Methods
Patients with tumors 3 cm or larger were treated with neoadjuvant anastrozole for 24 weeks, and concurrent radiation was administered from 12 weeks after the start of anastrozole. Core biopsies were obtained at baseline and 12 weeks after the start of anastrozole. After completing neoadjuvant treatment, patients underwent definitive surgery. The primary endpoint was the overall objective response. In addition, we assessed the predictive factors for clinical and pathological response for concurrent anastrozole and radiotherapy. This trial is registered with the UMIN Clinical Trials Registry, no. UMIN000002266.Results
The overall objective response rate was 92 %. Toxicity during neoadjuvant therapy was acceptable, with no grade 3 toxicities. After surgery, grade 3 toxicities occurred in 2 of 25 patients (8 %).Conclusions
Our preliminary data suggest that neoadjuvant anastrozole and radiation therapy in postmenopausal breast cancer patients with hormone-receptor-positive tumors has a high potential for clinical response. 相似文献709.
Hiroyuki Murota Saori Itoi Mika Terao Saki Matsui Hiromi Kawai Yasunari Satou Kazuma Suda Ichiro Katayama 《Experimental dermatology》2014,23(1):68-70
Changes in the stratum corneum extracellular matrix impair epidermal barrier function and may cause dermatoses. The aim of this study was to examine the effect of exogenous cholesterol application on skin barrier function and cutaneous inflammation. Skin barrier‐disrupted or hapten‐stimulated mice were treated with topical cholesterol. The effect of topical cholesterol application on an oxazolone (OXA)‐induced hypersensitivity reaction was evaluated. Topical application of cholesterol efficiently decreased transepidermal water loss in areas of barrier‐disrupted skin and ameliorated OXA‐induced cutaneous hypersensitivity. These favourable effects may have resulted from sustained expression of 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) in the cholesterol‐treated skin. As 11β‐HSD1 is known to produce active cortisol, topical cholesterol may attenuate contact hypersensitivity by normalizing secretion of hormonally active cortisol from the skin. 相似文献
710.