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91.
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog 总被引:15,自引:0,他引:15 下载免费PDF全文
92.
Epidemiology and outcomes of ventilator-associated pneumonia in a large US database 总被引:52,自引:0,他引:52
Rello J Ollendorf DA Oster G Vera-Llonch M Bellm L Redman R Kollef MH;VAP Outcomes Scientific Advisory Group 《Chest》2002,122(6):2115-2121
OBJECTIVES: To evaluate risk factors for ventilator-associated pneumonia (VAP), as well as its influence on in-hospital mortality, resource utilization, and hospital charges. DESIGN: Retrospective matched cohort study using data from a large US inpatient database. PATIENTS: Patients admitted to an ICU between January 1998 and June 1999 who received mechanical ventilation for > 24 h. MEASUREMENTS: Risk factors for VAP were examined using crude and adjusted odds ratios (AORs). Cases of VAP were matched on duration of mechanical ventilation, severity of illness on admission (predicted mortality), type of admission (medical, surgical, trauma), and age with up to three control subjects. Mortality, resource utilization, and billed hospital charges were then compared between cases and control subjects. RESULTS: Of the 9,080 patients meeting study entry criteria, VAP developed in 842 patients (9.3%). The mean interval between intubation, admission to the ICU, hospital admission, and the identification of VAP was 3.3 days, 4.5 days, and 5.4 days, respectively. Identified independent risk factors for the development of VAP were male gender, trauma admission, and intermediate deciles of underlying illness severity (on admission) [AOR, 1.58, 1.75, and 1.47 to 1.70, respectively]. Patients with VAP were matched with 2,243 control subjects without VAP. Hospital mortality did not differ significantly between cases and matched control subjects (30.5% vs 30.4%, p = 0.713). Nevertheless, patients with VAP had a significantly longer duration of mechanical ventilation (14.3 +/- 15.5 days vs 4.7 +/- 7.0 days, p < 0.001), ICU stay (11.7 +/- 11.0 days vs 5.6 +/- 6.1 days, p < 0.001), and hospital stay (25.5 +/- 22.8 days vs 14.0 +/- 14.6 days, p < 0.001). Development of VAP was also associated with an increase of > $40,000 USD in mean hospital charges per patient ($104,983 USD +/- $91,080 USD vs $63,689 USD+/- $75,030 USD, p < 0.001). CONCLUSIONS: This retrospective matched cohort study, the largest of its kind, demonstrates that VAP is a common nosocomial infection that is associated with poor clinical and economic outcomes. While strategies to prevent the occurrence of VAP may not reduce mortality, they may yield other important benefits to patients, their families, and hospital systems. 相似文献
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Elizabeth J. Baker Nancy A. Beck Ellen L. Berg Helene D. Clayton-Jeter P. Charukeshi Chandrasekera J. Lowry Curley Bruce A. Donzanti Lorna C. Ewart Jane M. Gunther J. Gerry Kenna Edward L. LeCluyse Michael N. Liebman Catherine L. Pugh Paul B. Watkins Kristie M. Sullivan 《Drug discovery today》2019,24(2):624-628
95.
Leviton Alan Joseph Robert M. Fichorova Raina N. Allred Elizabeth N. Gerry Taylor H. Michael O’Shea T. Dammann Olaf 《Journal of neuroimmune pharmacology》2019,14(2):188-199
Journal of Neuroimmune Pharmacology - We evaluated the relationship between blood levels of inflammatory and neurotrophic proteins during the first postnatal month in 692 children born before the... 相似文献
96.
Mark H. Yazer Beth Shaz Jansen N. Seheult Torunn O. Apelseth Dirk de Korte Gerry Devin Dana Devine Cheryl Doncaster Stephen Field Peter Flanagan Julie Huet Alfredo Mendrone Jr Cath O’Brien Joanne Pink Mark Rashleigh Eilat Shinar Minoko Takanashi Eka Tian Pierre Tiberghien Karin van den Berg Colby Schmitt 《Vox sanguinis》2020,115(8):703-711
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Amanda J. Nicoll Stuart K. Roberts Ricky Lim Joanne Mitchell Martin Weltman Jacob George Alan Wigg Katherine Stuart Paul Gow Gerry MacQuillan Edmund Tse Miriam Levy Siddharth Sood Amany Zekry Wendy Cheng Jonathan Mitchell Richard Skoien William Sievert Simone I. Strasser Geoffrey W. McCaughan 《Alimentary pharmacology & therapeutics》2019,49(10):1314-1322
100.
Anke Korfage Gerry M. RaghoebarJames J.R. Huddleston Slater Jan L.N. RoodenburgMax J.H. Witjes Arjan VissinkHarry Reintsema 《The British journal of oral & maxillofacial surgery》2014
We aimed to assess oral functioning, patients’ satisfaction, condition of peri-implant tissues, and survival of implants up to 14 years after their insertion in patients with oral cancer who had had mandibular overdentures placed over primary implants. Endosseous dental implants were inserted prospectively in the interforaminal region of the mandible during resection of the tumour in 164/180 patients with oral cancer. All 58 patients were evaluated by questionnaires and clinical assessments during a final assessment in 2012. Implant-retained mandibular overdentures were inserted, and prosthetic rehabilitation and oral functioning were not associated with primary site or stage of the tumour, number or type of implants inserted, or the type of reconstruction. Over time the peri-implant mucosa was usually free of inflammation. More implants were lost in patients treated by radiotherapy (27/318, 8.5%) than in those not so treated (1/206, 0.5%). Patients who had been treated by irradiation reported more problems in oral functioning and less satisfaction than those who had not. Patients with an implant-retained mandibular overdenture reported fewer problems in oral functioning than patients without an overdenture. 相似文献