全文获取类型
收费全文 | 1803篇 |
免费 | 119篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 12篇 |
妇产科学 | 22篇 |
基础医学 | 364篇 |
口腔科学 | 133篇 |
临床医学 | 230篇 |
内科学 | 215篇 |
皮肤病学 | 13篇 |
神经病学 | 278篇 |
特种医学 | 96篇 |
外科学 | 239篇 |
综合类 | 7篇 |
一般理论 | 1篇 |
预防医学 | 82篇 |
眼科学 | 4篇 |
药学 | 152篇 |
中国医学 | 1篇 |
肿瘤学 | 43篇 |
出版年
2022年 | 11篇 |
2021年 | 14篇 |
2020年 | 13篇 |
2017年 | 16篇 |
2016年 | 20篇 |
2015年 | 22篇 |
2014年 | 31篇 |
2013年 | 41篇 |
2012年 | 54篇 |
2011年 | 99篇 |
2010年 | 71篇 |
2009年 | 54篇 |
2008年 | 72篇 |
2007年 | 80篇 |
2006年 | 95篇 |
2005年 | 73篇 |
2004年 | 69篇 |
2003年 | 90篇 |
2002年 | 85篇 |
2001年 | 86篇 |
2000年 | 53篇 |
1999年 | 44篇 |
1998年 | 18篇 |
1997年 | 17篇 |
1996年 | 24篇 |
1995年 | 15篇 |
1994年 | 16篇 |
1993年 | 17篇 |
1992年 | 29篇 |
1991年 | 32篇 |
1990年 | 21篇 |
1989年 | 41篇 |
1988年 | 30篇 |
1987年 | 22篇 |
1986年 | 33篇 |
1985年 | 14篇 |
1984年 | 20篇 |
1983年 | 13篇 |
1981年 | 11篇 |
1980年 | 15篇 |
1979年 | 19篇 |
1978年 | 12篇 |
1977年 | 16篇 |
1976年 | 12篇 |
1975年 | 11篇 |
1972年 | 12篇 |
1970年 | 12篇 |
1969年 | 11篇 |
1966年 | 13篇 |
1933年 | 11篇 |
排序方式: 共有1925条查询结果,搜索用时 15 毫秒
41.
High‐Resolution HLA Typing for Sensitized Patients: Advances in Medicine and Science Require Us to Challenge Existing Paradigms 下载免费PDF全文
R. J. Duquesnoy H. M. Gebel E. S. Woodle P. Nickerson L. A. Baxter‐Lowe R. A. Bray F. H. J. Claas D. D. Eckels J. J. Friedewald S. V. Fuggle J. A. Gerlach J. J. Fung M. Kamoun D. Middleton R. Shapiro A. R. Tambur C. J. Taylor K. Tinckam A. Zeevi 《American journal of transplantation》2015,15(10):2780-2781
42.
43.
44.
Oliver H.H. Gerlach Martijn P.G. Broen Wim E.J. Weber 《Parkinsonism & related disorders》2013,19(8):737-741
BackgroundRetrospective studies suggest that many Parkinson's disease patients have a worsening of their motor status during hospitalization. We aimed to quantify this prospectively, and study possible contributing factors.MethodsOver one year we included all consecutive Parkinson's disease patients, newly admitted to a Dutch teaching hospital. We analyzed complications, interventions, and medication distribution. At inclusion and at discharge we assessed the motor status with the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III).Results48% of 46 admitted patients had complications, mainly confusion/delirium (24%) and infections (15%). At discharge 28% of the patients had a worse motor function with a mean increase of more than 5 points on the UPDRS-III. Medication errors occurred in 39%. This is the most important risk factor (p < 0.000) for motor function deterioration, followed by infections during hospitalization, and not being in control of own Parkinson's disease medication. 24% of patients were allowed to take control of their own Parkinson's disease medication, none of these patients did deteriorate.ConclusionsThis prospective study shows that a substantial part of hospitalized PD patients has a significant worse motor function at discharge mainly due to medication errors and infections. Quality of care could be improved by addressing preventable errors and allow patients to take control of their own Parkinson's disease medication. 相似文献
45.
Monika Milian Juergen Honegger Christine Gerlach Tsambika Psaras 《Acta neurochirurgica》2013,155(9):1637-1645
Background
Reduced health-related quality of life (HRQoL) is a common complaint in patients suffering from pituitary tumors. Although successful tumor treatment has been reported to lead to an improvement in perceived HRQoL, the temporal gradient at which these improvements occur has not been fully addressed.Methods
Using three validated health-related questionnaires (SF-36, SCL-90-R, QLS-H), we assessed HRQoL in 106 adult patients harboring pituitary tumors (mean age 48.0?±?16.0 years) before as well as 3 and 12 months after initiation of treatment. The AcroQoL questionnaire was additionally applied in acromegalic patients.Results
There was a significant improvement in all but one scale (role-physical) of the SF-36 questionnaire and all but two scales (interpersonal sensitivity, paranoid ideation) of the SCL-90-R, the QLS-H score and the AcroQoL subscales within 3 months after surgical treatment. The trend to amelioration continued at the 12 month re-assessment, but did not reach statistical significance. Linear regression analyses revealed that younger age and male gender favor a more distinct improvement of HRQoL after treatment.Conclusions
HRQoL is considerably reduced before treatment for pituitary disease. Improvement is an early postoperative phenomenon and occurs within 3 months after treatment. Men and younger patients are more likely to improve within this time span. 相似文献46.
47.
Stickel F Helbling B Heim M Geier A Hirschi C Terziroli B Wehr K De Gottardi A Negro F Gerlach T 《Journal of viral hepatitis》2012,19(2):77-87
Summary. Combined pegylated interferon (PegIFN) and ribavirin represents the standard therapy for patients with chronic hepatitis C (CHC), which allows for sustained viral response (SVR) in up to 90% of patients depending on certain viral and host factors. Clinical studies have demonstrated the importance of adherence to therapy, that is, the ability of patients to tolerate and sustain a fully dosed therapy regimen. Adherence is markedly impaired by treatment‐related adverse effects. In particular, haemolytic anaemia often requires dose reduction or termination of ribavirin treatment, which compromises treatment efficacy. Recent evidence points to a beneficial role of recombinant erythropoietin (EPO) in alleviating ribavirin‐induced anaemia thereby improving quality of life, enabling higher ribavirin dosage and consequently improving SVR. However, no general consensus exists regarding the use of EPO for specific indications: its optimal dosing, treatment benefits and potential risks or cost efficiency. The Swiss Association for the Study of the Liver (SASL) has therefore organized an expert meeting to critically review and discuss the current evidence and to phrase recommendations for clinical practice. A consensus was reached recommending the use of EPO for patients infected with viral genotype 1 developing significant anaemia below 100 g/L haemoglobin and a haematocrit of <30% during standard therapy to improve quality of life and sustain optimal ribavirin dose. However, the evidence supporting its use in patients with pre‐existing anaemia, non‐1 viral genotypes, a former relapse or nonresponse, liver transplant recipients and cardiovascular or pulmonary disease is considered insufficient. 相似文献
48.
Background
Joint infections represent a severe complication that results in irreversible joint destruction when inadequately treated. The causes of joint infections consist of endogenous, hematological and exogenous factors. The patients in this cohort acquired empyema almost solely through iatrogenic means (e.g. arthroscopic operations, punctures and intra-articular infections) or as a result of fractures close to joints and penetrating injuries.Diagnostics
In order to make a correct diagnosis, a joint puncture with a direct swab test is necessary in addition to laboratory examinations, x-ray and magnetic resonance imaging (MRI). The amount of leucocytes is to be determined (threshold value 25,000/μl) as well as gram staining to identify any bacteria present.Therapy
Acute joint infections are considered to be orthopedic emergencies and immediate surgery is necessary, as irreversible cartilage damage can quickly result due to pathophysiological processes. Acute joint empyema must be treated arthroscopically. Clinical symptoms lasting more than 7 days result in chronic empyema. Chronic empyema should be treated by arthrotomy, synovectomy and the removal of extraneous material including cruciate ligament replacement. Postoperatively, an immediate intensive physiotherapy is necessary, even under the use of pain catheters and transfer to a center specialized in septic surgery is warranted.49.
50.