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John Simwanza Jonas Z. Hines Danny Sinyange Nyambe Sinyange Chilufya Mulenga Sarah Hanyinza Patrick Sakubita Nelia Langa Haggai Nowa Priscilla Gardner Ngonda Saasa Graham Chitempa James Simpungwe Warren Malambo Busiku Hamainza Peter J. Chipimo Nathan Kapata Muzala Kapina Kunda Musonda Mazyanga Liwewe Consity Mwale Sombo Fwoloshi Lloyd B. Mulenga Simon Agolory Victor Mukonka Roma Chilengi 《The American journal of tropical medicine and hygiene》2022,107(5):1055
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Yves Aubert Morgan L. Gustison Lindsey A. Gardner Michael A. Bohl Jason R. Lange Kelly A. Allers Bernd Sommer Nicole A. Datson David H. Abbott 《The journal of sexual medicine》2012,9(3):694-707
IntroductionPsychopathological origins of personally distressing, hypoactive sexual desire disorder (HSDD) in women are unknown, but are generally attributed to an inhibitory neural regulator, serotonin (5‐HT). Flibanserin, a 5‐HT1A agonist and 5‐HT2A antagonist, shows promise as a treatment for HSDD.AimTo test the hypothesis that female marmoset sexual behavior is enhanced by flibanserin and diminished by 8‐OH‐DPAT, in order to evaluate the efficacy of serotonergic modulation of female sexual behavior in a pairmate social setting comparable to humans.MethodsSexual and social behavior were examined in eight female marmoset monkeys receiving daily flibanserin (15 mg/kg), 8‐OH‐DPAT (0.1 mg/kg), or corresponding vehicle for 15–16 weeks in a counterbalanced, within‐subject design, while housed in long‐term, stable male–female pairs.Main Outcome MeasuresMarmoset pairmate interactions, including sexual and social behavior, were scored during weeks 5–6 of daily flibanserin, 8‐OH‐DPAT or vehicle treatment. 24‐hour pharmacokinetic profiles of the drugs and their metabolites, as well as drug‐induced acute symptoms of the 5‐HT behavioral syndrome were also assessed.ResultsTwo‐way analysis of variance reveals that flibanserin‐treated females attract more male sexual interest (P = 0.020) and trigger increased grooming (P = 0.001) between partners. In contrast, 8‐OH‐DPAT‐treated females show increased rejection of male sexual advances (P = 0.024), a tendency for decreased male sexual interest (P = 0.080), and increased aggression with their male pairmates (P = 0.049).ConclusionsWhile 8‐OH‐DPAT‐treated female marmosets display decreased sexual receptivity and increased aggressive interactions with their male pairmates, flibanserin‐treated female marmosets demonstrate increased affiliative behavior with their male pairmates. Such pro‐affiliation attributes may underlie flibanserin's effectiveness in treating HSDD in women. Aubert Y, Gustison ML, Gardner LA, Bohl MA, Lange JR, Allers KA, Sommer B, Datson NA, and Abbott DH. Flibanserin and 8‐OH‐DPAT implicate serotonin in association between female marmoset monkey sexual behavior and changes in pair‐bond quality. J Sex Med 2012;9:694–707. 相似文献
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