全文获取类型
收费全文 | 1219篇 |
免费 | 140篇 |
国内免费 | 49篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 102篇 |
妇产科学 | 17篇 |
基础医学 | 99篇 |
口腔科学 | 45篇 |
临床医学 | 105篇 |
内科学 | 330篇 |
皮肤病学 | 29篇 |
神经病学 | 43篇 |
特种医学 | 192篇 |
外科学 | 109篇 |
综合类 | 98篇 |
预防医学 | 74篇 |
眼科学 | 9篇 |
药学 | 66篇 |
中国医学 | 3篇 |
肿瘤学 | 65篇 |
出版年
2023年 | 17篇 |
2022年 | 13篇 |
2021年 | 26篇 |
2020年 | 21篇 |
2019年 | 10篇 |
2018年 | 21篇 |
2017年 | 43篇 |
2016年 | 38篇 |
2015年 | 31篇 |
2014年 | 63篇 |
2013年 | 73篇 |
2012年 | 28篇 |
2011年 | 25篇 |
2010年 | 64篇 |
2009年 | 73篇 |
2008年 | 29篇 |
2007年 | 76篇 |
2006年 | 39篇 |
2005年 | 28篇 |
2004年 | 23篇 |
2003年 | 16篇 |
2002年 | 10篇 |
2001年 | 30篇 |
2000年 | 13篇 |
1999年 | 18篇 |
1998年 | 78篇 |
1997年 | 65篇 |
1996年 | 60篇 |
1995年 | 51篇 |
1994年 | 45篇 |
1993年 | 42篇 |
1992年 | 10篇 |
1991年 | 6篇 |
1990年 | 18篇 |
1989年 | 26篇 |
1988年 | 24篇 |
1987年 | 15篇 |
1986年 | 20篇 |
1985年 | 21篇 |
1984年 | 11篇 |
1983年 | 12篇 |
1982年 | 10篇 |
1981年 | 5篇 |
1980年 | 8篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 12篇 |
1975年 | 11篇 |
1970年 | 3篇 |
排序方式: 共有1408条查询结果,搜索用时 31 毫秒
81.
82.
83.
Background
Despite extensive research, the five-year survival rate of oral squamous cell carcinoma (OSCC) patients has not improved. Effective treatment of OSCC requires the identification of molecular targets and signaling pathways to design appropriate therapeutic strategies. Several genes from the mTOR signaling pathway are known to be dysregulated in a wide spectrum of cancers. However, not much is known about the involvement of this pathway in tumorigenesis of OSCC. We therefore investigated the role of the tumor suppressor genes, TSC1 and TSC2, and other members of this pathway in tumorigenesis of OSCC. 相似文献84.
85.
Carriage of Haemophilus influenzae and Streptococcus pneumoniae in healthy Chinese and Vietnamese children in Hong Kong 总被引:1,自引:0,他引:1
RYT Sung JM Ling SM Fung SJ Oppenheimer DW Crook JTF Lau AFB Cheng 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(11):1262-1267
Nasopharyngeal carriage of Haemophilus influenzae and Streptococcus pneumoniae was studied in 621 healthy Chinese children and 300 healthy Vietnamese children aged from 2 months to 5 years in Hong Kong. The carriage rate of H, influenzae type b in Vietnamese children was 1.3% (CI 0.04-2.63%); it was zero in Chinese. The carriage rate of non-typable H. influenzae was 5.8% (CI 1.4-7.6%) in Chinese and 65.4% (CI 58.9-69.8%) in Vietnamese. The carriage rates of S. pneumoniae were 10.8% (CI 8.3-13.2%) and 55.7% (CI 50.1-61.3%) in Chinese and Vietnamese children, respectively. Univariate and multivariate logistic regression analyses were performed to search for factors associated with differences in carriage rates of both H. influenzae and S. pneumoniae between Chinese and Vietnamese children. Although older age, smaller living area and parental smoking were associated with higher carriage rates, these could not explain the remarkably low carriage rates of both bacteria in Chinese children. 相似文献
86.
SF Slaney AO Wilkie MC Hirst R Charlton M McKinley J Pointon Z Christodoulou SM Huson KE Davies 《Archives of disease in childhood》1995,72(1):33-37
Fragile X syndrome is the most common inherited cause of mental retardation. Early diagnosis is important not only for appropriate management of individuals but also to identify carriers who are unaware of their high risk of having an affected child. The disorder is associated with a cytogenetically visible fragile site (FRAXA) at Xq27.3, caused by amplification of a (CGG)n repeat sequence within the gene at this locus designated FMR1. Clinical and molecular studies have been undertaken to screen for fragile X syndrome in 154 children with moderate and severe learning difficulties of previously unknown origin. Southern blot analysis of peripheral blood showed the characteristic abnormally large (CGG)n repeat sequence associated with fragile X syndrome in four of the 154 children. The findings were confirmed by cytogenetic observation of the fragile site and by further molecular studies. The families of the affected children were offered genetic counselling and DNA tests to determine their carrier status. These findings show that there are still unrecognised cases of fragile X syndrome. Given the difficulty of making a clinical diagnosis and the implications for families when the diagnosis is missed, screening in high risk populations may be justified. The issues involved in screening all children in special schools for fragile X syndrome are discussed. 相似文献
87.
Growth, puberty and obesity after treatment for leukaemia 总被引:1,自引:0,他引:1
HA Davies E Didcock M Didi A Ogilvy-Stuart JKH Wales SM Shalet 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(S411):45-50
Final height, body proportions, pubertal growth and body mass index were studied retrospectively in 142 survivors of acute lymphoblastic leukaemia (ALL). Treatment consisted of combination chemotherapy and cranial irradiation (18 or 24 Gy). Significant standing height loss and disproportion, with a relatively short back, was seen in both radiation dose groups. Girls were more severely affected than boys. Pubertal growth was adversely affected, with a reduction in peak height velocity in both sexes. Puberty occurred early in girls but at the normal time in boys. Nearly half the group were obese at final height, with no significant difference in incidence between the sexes. The relative roles of cranial irradiation and chemotherapy in the disturbance of growth, puberty and body composition observed in survivors of childhood ALL remain unclear. The aetiology is almost certainly multifactorial, with radiation-induced growth hormone insufficiency, early puberty, steroids and chemotherapy all having a role. 相似文献
88.
AM Boot J Nauta AC Hokken-Koelega HA Pols MA de Ridder SM de Muinck Keizer-Schrama 《Archives of disease in childhood》1995,72(6):502-506
A cross sectional study assessed the bone mineral density (BMD) of 20 young adult patients who received a renal transplantation in childhood. The BMD of the lumbar spine, mainly trabecular bone, and of the total body, mainly cortical bone, were measured and expressed as an SD score. Fourteen patients (70%) had a BMD SD score of the lumbar spine below -1, of whom six patients were below -2. Fifteen patients (75%) had a BMD SD score of the total body below -1, of whom seven patients were below -2, Both trabecular and cortical bone appeared to be involved in the osteopenic process. The cumulative dose of prednisone was inversely correlated to both lumbar spine and total body BMD SD score. In a multiple regression analysis the cumulative dose of prednisone appeared to be the only factor with a significant effect on BMD SD score. Most young adult patients who had received a renal transplantation in childhood had moderate to severe osteopenia. Corticosteroid treatment played a major part in the development of osteopenia in these patients. 相似文献
89.
90.
G Larcos SM Gruenewald JP Fletcher 《Journal of Medical Imaging and Radiation Oncology》1995,39(3):254-256
Recent observations suggest that first degree relatives of patients with an abdominal aortic aneurysm (AAA) are also at risk for the development of this disorder. The first degree relatives of 130 adults with known AAA were invited to attend for an ultrasound examination. Fifty-two eligible relatives (mean age 53 years, range 41–73) from 38 families underwent sonographic screening. Using standard ultrasound criteria no participants were identified with an asymptomatic AAA. Thus, ultrasound of families of patients with AAA has a low yield and may not be useful for screening purposes. 相似文献